Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy
Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of his...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2016-12-01
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| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | http://www.revistas.usp.br/autopsy/article/view/125444 |
| _version_ | 1818114556716646400 |
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| author | Reuben Kiggundu Henry W. Nabeta Richard Okia Joshua Rhein Robert Lukande |
| author_facet | Reuben Kiggundu Henry W. Nabeta Richard Okia Joshua Rhein Robert Lukande |
| author_sort | Reuben Kiggundu |
| collection | DOAJ |
| description | Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. We report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to Histoplasma capsulatum var. capsulatum 4 months after the onset of the antiretroviral therapy and some improvement in the immune reconstitution. After 2 weeks of amphotericin B and itraconazole therapy, the scheduled treatment involved fluconazole maintenance therapy, which resulted in an improvement of his skin lesions |
| first_indexed | 2024-12-11T03:52:37Z |
| format | Article |
| id | doaj.art-e5b11ff938994a15a79cc8c42be36d39 |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-11T03:52:37Z |
| publishDate | 2016-12-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-e5b11ff938994a15a79cc8c42be36d392022-12-22T01:21:52ZengUniversity of São PauloAutopsy and Case Reports2236-19602016-12-016410.4322/acr.2016.048Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapyReuben Kiggundu0Henry W. Nabeta1Richard Okia2Joshua Rhein3Robert Lukande4Makerere University. Infectious Disease Institute. College of Health SciencesMakerere University. School of Medicine. College of Health SciencesMakerere University. School of Medicine. College of Health SciencesMakerere University. Infectious Disease Institute. College of Health Sciences University of Minnesota. Department of MedicineMakerere University. School of Biomedical Sciences. College of Health SciencesHistoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. We report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to Histoplasma capsulatum var. capsulatum 4 months after the onset of the antiretroviral therapy and some improvement in the immune reconstitution. After 2 weeks of amphotericin B and itraconazole therapy, the scheduled treatment involved fluconazole maintenance therapy, which resulted in an improvement of his skin lesionshttp://www.revistas.usp.br/autopsy/article/view/125444HistoplasmosisImmune Reconstitution Inflammatory SyndromeAntiretroviral TherapyHighly ActiveFluconazole |
| spellingShingle | Reuben Kiggundu Henry W. Nabeta Richard Okia Joshua Rhein Robert Lukande Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy Autopsy and Case Reports Histoplasmosis Immune Reconstitution Inflammatory Syndrome Antiretroviral Therapy Highly Active Fluconazole |
| title | Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy |
| title_full | Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy |
| title_fullStr | Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy |
| title_full_unstemmed | Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy |
| title_short | Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy |
| title_sort | unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy |
| topic | Histoplasmosis Immune Reconstitution Inflammatory Syndrome Antiretroviral Therapy Highly Active Fluconazole |
| url | http://www.revistas.usp.br/autopsy/article/view/125444 |
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