Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice
Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464621002528 |
| _version_ | 1818886170879197184 |
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| author | Yao Lu Yutao Zhou Yingying Lin Wusun Li Shousheng Tian Xianghui Hao Huiyuan Guo |
| author_facet | Yao Lu Yutao Zhou Yingying Lin Wusun Li Shousheng Tian Xianghui Hao Huiyuan Guo |
| author_sort | Yao Lu |
| collection | DOAJ |
| description | Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma. |
| first_indexed | 2024-12-19T16:17:05Z |
| format | Article |
| id | doaj.art-e5b601fecfb24499b001827ab8e455b5 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-19T16:17:05Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e5b601fecfb24499b001827ab8e455b52022-12-21T20:14:36ZengElsevierJournal of Functional Foods1756-46462021-09-0184104603Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic miceYao Lu0Yutao Zhou1Yingying Lin2Wusun Li3Shousheng Tian4Xianghui Hao5Huiyuan Guo6Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 10083, ChinaKey Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 10083, ChinaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 10083, ChinaBeijing Laboratory of Food Quality and Safety, China Agricultural University, Beijing 10083, ChinaNational Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong-E E-Jiao Co. Ltd., No. 78, E-jiao Street, Done-E Country, Shandong Province 252201, ChinaNational Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong-E E-Jiao Co. Ltd., No. 78, E-jiao Street, Done-E Country, Shandong Province 252201, ChinaKey Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 10083, China; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 10083, China; Corresponding author at: Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 10083, China.Allergic asthma, a globally growing respiratory disease, is associated with airway hyperresponsiveness (AHR), airway remodeling, mucus hypersecretion and T-helper type (Th) 2 inflammatory responses. Donkey milk, similar to human milk in composition, has potential in asthma remission considering its anti-inflammatory properties and components. We explored the effects of oral administration with donkey milk powder (DML; 0.4, 2, and 10 g/kg) on mice under ovalbumin (OVA) challenge. We found DMP ameliorated AHR and postponed manifestation of asthma. Additionally, DMP relieved the injury and fibrosis of airway epithelium. Besides, it alleviated mucin 5AC (MUC5AC) accumulation along with goblet cell hyperplasia in lung tissues and also downregulated the stimulated MUC5AC expression in human airway epithelial cell line NCI-H292. Moreover, DMP reduced airway eosinophilia and the increased Th2 cytokines in bronchoalveolar lavage fluid as well as serum immunoglobulin E, and inhibited NF-κB P65 activity. These results indicated preventive effects of DMP on OVA-induced asthma.http://www.sciencedirect.com/science/article/pii/S1756464621002528Donkey milk powderAllergic asthmaAirway hyperresponsivenessAirway remodelingMucus hypersecretionAirway inflammation |
| spellingShingle | Yao Lu Yutao Zhou Yingying Lin Wusun Li Shousheng Tian Xianghui Hao Huiyuan Guo Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice Journal of Functional Foods Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation |
| title | Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice |
| title_full | Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice |
| title_fullStr | Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice |
| title_full_unstemmed | Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice |
| title_short | Preventive effects of donkey milk powder on the ovalbumin-induced asthmatic mice |
| title_sort | preventive effects of donkey milk powder on the ovalbumin induced asthmatic mice |
| topic | Donkey milk powder Allergic asthma Airway hyperresponsiveness Airway remodeling Mucus hypersecretion Airway inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464621002528 |
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