Long-term L-3-n-butylphthalide pretreatment attenuates ischemic brain injury in mice with permanent distal middle cerebral artery occlusion through the Nrf2 pathway

Long-term L-3-n-butylphthalide pretreatment attenuates ischemic brain injury in mice with permanent distal middle cerebral artery occlusion through the Nrf2 pathway

L-3-n-butylphthalide (NBP), which is used for treatment of mild and moderate acute ischemic stroke, exerts its effects by modulating the Nrf2 pathway. However, it has not been established whether NBP exerts its preventive effects in high-risk ischemic stroke patients through the Nrf2 pathway. We inv...

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Bibliographic Details
Main Authors: Mingying Sun, Changchun Jiang, Xiwa Hao, Jiangxia Pang, Chao Chen, Wenping Xiang, Jun Zhang, Shijun Zhao, Po Wang, Shangyong Geng, Hanzhang Wang, Yuechun Li, Baojun Wang
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Heliyon
Subjects:
Brain ischemia
L-3-n-butylphthalide
Nrf2 signaling pathway
Oxidative stress
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022011975

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