Development of glioblastoma organoids and their applications in personalized therapy
Glioblastomas (GBMs) are the brain tumors with the highest malignancy and poorest prognoses. GBM is characterized by high heterogeneity and resistance to drug treatment. Organoids are 3-dimensional cultures that are constructed in vitro and comprise cell types highly similar to those in organs or ti...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2023-05-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | https://www.cancerbiomed.org/content/20/5/353 |
| _version_ | 1797809610415931392 |
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| author | Can Xu Xiaoye Yuan Pengyu Hou Ziru Li Changsheng Wang Chuan Fang Yanli Tan |
| author_facet | Can Xu Xiaoye Yuan Pengyu Hou Ziru Li Changsheng Wang Chuan Fang Yanli Tan |
| author_sort | Can Xu |
| collection | DOAJ |
| description | Glioblastomas (GBMs) are the brain tumors with the highest malignancy and poorest prognoses. GBM is characterized by high heterogeneity and resistance to drug treatment. Organoids are 3-dimensional cultures that are constructed in vitro and comprise cell types highly similar to those in organs or tissues in vivo, thus simulating specific structures and physiological functions of organs. Organoids have been technically developed into an advanced ex vivo disease model used in basic and preclinical research on tumors. Brain organoids, which simulate the brain microenvironment while preserving tumor heterogeneity, have been used to predict patients’ therapeutic responses to antitumor drugs, thus enabling a breakthrough in glioma research. GBM organoids provide an effective supplementary model that reflects human tumors’ biological characteristics and functions in vitro more directly and accurately than traditional experimental models. Therefore, GBM organoids are widely applicable in disease mechanism research, drug development and screening, and glioma precision treatments. This review focuses on the development of various GBM organoid models and their applications in identifying new individualized therapies against drug-resistant GBM. |
| first_indexed | 2024-03-13T06:56:20Z |
| format | Article |
| id | doaj.art-e5b8af7ddc7641539d75ce08527182fd |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-03-13T06:56:20Z |
| publishDate | 2023-05-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-e5b8af7ddc7641539d75ce08527182fd2023-06-07T11:44:09ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412023-05-0120535336810.20892/j.issn.2095-3941.2023.0061Development of glioblastoma organoids and their applications in personalized therapyCan Xu0Xiaoye Yuan1Pengyu Hou2Ziru Li3Changsheng Wang4Chuan Fang5Yanli Tan6School of Clinical Medicine, Hebei University, Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 07100, ChinaSchool of Basic Medical Sciences, Hebei University, Baoding 07100, ChinaSchool of Basic Medical Sciences, Hebei University, Baoding 07100, ChinaSchool of Basic Medical Sciences, Hebei University, Baoding 07100, ChinaSchool of Clinical Medicine, Hebei University, Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 07100, ChinaSchool of Clinical Medicine, Hebei University, Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 07100, ChinaSchool of Basic Medical Sciences, Hebei University, Baoding 07100, ChinaGlioblastomas (GBMs) are the brain tumors with the highest malignancy and poorest prognoses. GBM is characterized by high heterogeneity and resistance to drug treatment. Organoids are 3-dimensional cultures that are constructed in vitro and comprise cell types highly similar to those in organs or tissues in vivo, thus simulating specific structures and physiological functions of organs. Organoids have been technically developed into an advanced ex vivo disease model used in basic and preclinical research on tumors. Brain organoids, which simulate the brain microenvironment while preserving tumor heterogeneity, have been used to predict patients’ therapeutic responses to antitumor drugs, thus enabling a breakthrough in glioma research. GBM organoids provide an effective supplementary model that reflects human tumors’ biological characteristics and functions in vitro more directly and accurately than traditional experimental models. Therefore, GBM organoids are widely applicable in disease mechanism research, drug development and screening, and glioma precision treatments. This review focuses on the development of various GBM organoid models and their applications in identifying new individualized therapies against drug-resistant GBM.https://www.cancerbiomed.org/content/20/5/353glioblastomaorganoidsglioma stem celldrug screening |
| spellingShingle | Can Xu Xiaoye Yuan Pengyu Hou Ziru Li Changsheng Wang Chuan Fang Yanli Tan Development of glioblastoma organoids and their applications in personalized therapy Cancer Biology & Medicine glioblastoma organoids glioma stem cell drug screening |
| title | Development of glioblastoma organoids and their applications in personalized therapy |
| title_full | Development of glioblastoma organoids and their applications in personalized therapy |
| title_fullStr | Development of glioblastoma organoids and their applications in personalized therapy |
| title_full_unstemmed | Development of glioblastoma organoids and their applications in personalized therapy |
| title_short | Development of glioblastoma organoids and their applications in personalized therapy |
| title_sort | development of glioblastoma organoids and their applications in personalized therapy |
| topic | glioblastoma organoids glioma stem cell drug screening |
| url | https://www.cancerbiomed.org/content/20/5/353 |
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