Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report
Endometrial cancer arising in adenomyosis (EC-AIA) is a rare form of uterine cancer. A 53-year-old Japanese postmenopausal female was referred to our outpatient clinic for adenomyosis. After the 4-year follow-up, she presented with an increased vaginal discharge. Endometrial curettage demonstrated e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Society of Tokyo Women's Medical University
2018-10-01
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| Series: | Tokyo Women's Medical University Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/twmuj/2/0/2_2018004/_pdf/-char/en |
| _version_ | 1818408465061642240 |
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| author | Hiroaki NAGANO Yuri FURUKAWA Mariko UENO Koichiro TAKAGI |
| author_facet | Hiroaki NAGANO Yuri FURUKAWA Mariko UENO Koichiro TAKAGI |
| author_sort | Hiroaki NAGANO |
| collection | DOAJ |
| description | Endometrial cancer arising in adenomyosis (EC-AIA) is a rare form of uterine cancer. A 53-year-old Japanese postmenopausal female was referred to our outpatient clinic for adenomyosis. After the 4-year follow-up, she presented with an increased vaginal discharge. Endometrial curettage demonstrated either atypical endometrial hyperplasia or well-differentiated endometrioid carcinoma. Positron emission tomography/computed tomography revealed multiple pulmonary metastases, pelvic bone metastases, para-aortic node metastases, and uterine tumor as the primary lesion. She was clinically diagnosed with stage IVB endometrial cancer. Accordingly, total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Macroscopic findings of the resected uterus were difficult to distinguish from ordinal adenomyosis. Microscopically, diffuse endometrioid carcinoma (grade 2) occupied the entire uterine body, coexisting with adenomyosis. Postoperatively, chemotherapy and zoledronic acid administration were initiated, which are ongoing till date. The case highlights that EC-AIA, a rare but aggressive disease, should be considered when managing patients with adenomyosis. |
| first_indexed | 2024-12-14T09:44:09Z |
| format | Article |
| id | doaj.art-e5b99814a3f94c1ea6224654339e83c6 |
| institution | Directory Open Access Journal |
| issn | 2432-6186 |
| language | English |
| last_indexed | 2024-12-14T09:44:09Z |
| publishDate | 2018-10-01 |
| publisher | Society of Tokyo Women's Medical University |
| record_format | Article |
| series | Tokyo Women's Medical University Journal |
| spelling | doaj.art-e5b99814a3f94c1ea6224654339e83c62022-12-21T23:07:43ZengSociety of Tokyo Women's Medical UniversityTokyo Women's Medical University Journal2432-61862018-10-0120404410.24488/twmuj.2018004twmujAdvanced Endometrial Cancer Arising in Adenomyosis: A Case ReportHiroaki NAGANO0Yuri FURUKAWA1Mariko UENO2Koichiro TAKAGI3Department of Obstetrics and Gynecology, Tokyo Women's Medical University Medical Center EastDepartment of Obstetrics and Gynecology, Tokyo Women's Medical University Medical Center EastDepartment of Obstetrics and Gynecology, Tokyo Women's Medical University Medical Center EastDepartment of Obstetrics and Gynecology, Tokyo Women's Medical University Medical Center EastEndometrial cancer arising in adenomyosis (EC-AIA) is a rare form of uterine cancer. A 53-year-old Japanese postmenopausal female was referred to our outpatient clinic for adenomyosis. After the 4-year follow-up, she presented with an increased vaginal discharge. Endometrial curettage demonstrated either atypical endometrial hyperplasia or well-differentiated endometrioid carcinoma. Positron emission tomography/computed tomography revealed multiple pulmonary metastases, pelvic bone metastases, para-aortic node metastases, and uterine tumor as the primary lesion. She was clinically diagnosed with stage IVB endometrial cancer. Accordingly, total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Macroscopic findings of the resected uterus were difficult to distinguish from ordinal adenomyosis. Microscopically, diffuse endometrioid carcinoma (grade 2) occupied the entire uterine body, coexisting with adenomyosis. Postoperatively, chemotherapy and zoledronic acid administration were initiated, which are ongoing till date. The case highlights that EC-AIA, a rare but aggressive disease, should be considered when managing patients with adenomyosis.https://www.jstage.jst.go.jp/article/twmuj/2/0/2_2018004/_pdf/-char/enendometrial carcinomaadenomyosismalignant transformation |
| spellingShingle | Hiroaki NAGANO Yuri FURUKAWA Mariko UENO Koichiro TAKAGI Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report Tokyo Women's Medical University Journal endometrial carcinoma adenomyosis malignant transformation |
| title | Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report |
| title_full | Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report |
| title_fullStr | Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report |
| title_full_unstemmed | Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report |
| title_short | Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report |
| title_sort | advanced endometrial cancer arising in adenomyosis a case report |
| topic | endometrial carcinoma adenomyosis malignant transformation |
| url | https://www.jstage.jst.go.jp/article/twmuj/2/0/2_2018004/_pdf/-char/en |
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