A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report
Hidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating ci...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-07-01
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| Series: | Case Reports in Dermatology |
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| Online Access: | http://www.karger.com/Article/FullText/473873 |
| _version_ | 1818110093814661120 |
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| author | Birgit N. Khandalavala |
| author_facet | Birgit N. Khandalavala |
| author_sort | Birgit N. Khandalavala |
| collection | DOAJ |
| description | Hidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. A combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated. Acute antibiotic use for recurrences and flares could be slowly discontinued. Over the course of 3 years on this regimen, the liver enzymes normalized in 1 year, followed in2 years by complete resolution of the majority of the hematological and metabolic abnormalities. The sedimentation rate reduced from over 120 to 34 mm/h. She required 1 surgical intervention for perianal disease after 9 months on the regimen. Flares greatly diminished in intensity and duration, with none in the past 6 months. Right axillary lesions have completely healed with residual disease greatly reduced. Chiefly abdominal lesions are persistent. She was able to complete high school from home, start a job, and resume a normal life. Initial weight loss of 40 pounds was not maintained. The current regimen is being well tolerated and continued. |
| first_indexed | 2024-12-11T02:41:40Z |
| format | Article |
| id | doaj.art-e5bd4c433566459f9840562597cd9ed3 |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-12-11T02:41:40Z |
| publishDate | 2017-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-e5bd4c433566459f9840562597cd9ed32022-12-22T01:23:34ZengKarger PublishersCase Reports in Dermatology1662-65672017-07-0192707810.1159/000473873473873A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case ReportBirgit N. KhandalavalaHidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. A combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated. Acute antibiotic use for recurrences and flares could be slowly discontinued. Over the course of 3 years on this regimen, the liver enzymes normalized in 1 year, followed in2 years by complete resolution of the majority of the hematological and metabolic abnormalities. The sedimentation rate reduced from over 120 to 34 mm/h. She required 1 surgical intervention for perianal disease after 9 months on the regimen. Flares greatly diminished in intensity and duration, with none in the past 6 months. Right axillary lesions have completely healed with residual disease greatly reduced. Chiefly abdominal lesions are persistent. She was able to complete high school from home, start a job, and resume a normal life. Initial weight loss of 40 pounds was not maintained. The current regimen is being well tolerated and continued.http://www.karger.com/Article/FullText/473873ThrombocytosisElevated liver enzymesElevated sedimentation rateHidradenitis suppurativaAcne inversaMetforminLiraglutideFinasterideDapsoneObesityWeight lossMetabolic syndromeAnemiaLeukocytosisElevated platelet count |
| spellingShingle | Birgit N. Khandalavala A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report Case Reports in Dermatology Thrombocytosis Elevated liver enzymes Elevated sedimentation rate Hidradenitis suppurativa Acne inversa Metformin Liraglutide Finasteride Dapsone Obesity Weight loss Metabolic syndrome Anemia Leukocytosis Elevated platelet count |
| title | A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report |
| title_full | A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report |
| title_fullStr | A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report |
| title_full_unstemmed | A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report |
| title_short | A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report |
| title_sort | disease modifying approach for advanced hidradenitis suppurativa regimen with metformin liraglutide dapsone and finasteride a case report |
| topic | Thrombocytosis Elevated liver enzymes Elevated sedimentation rate Hidradenitis suppurativa Acne inversa Metformin Liraglutide Finasteride Dapsone Obesity Weight loss Metabolic syndrome Anemia Leukocytosis Elevated platelet count |
| url | http://www.karger.com/Article/FullText/473873 |
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