Surgical and Oncological Outcomes of Salvage Hepatectomy for Locally Recurrent Hepatocellular Carcinoma after Locoregional Therapy: A Single-Institution Experience
Surgical and oncological outcomes of hepatectomy for recurrent hepatocellular carcinoma (HCC) after locoregional therapy, including locally recurrent HCC (LR-HCC), were examined. Among 273 consecutive patients who underwent hepatectomy for HCC, 102 with recurrent HCC were included and retrospectivel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/8/2320 |
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| author | Takuya Minagawa Osamu Itano Minoru Kitago Yuta Abe Hiroshi Yagi Taizo Hibi Masahiro Shinoda Hidenori Ojima Michiie Sakamoto Yuko Kitagawa |
| author_facet | Takuya Minagawa Osamu Itano Minoru Kitago Yuta Abe Hiroshi Yagi Taizo Hibi Masahiro Shinoda Hidenori Ojima Michiie Sakamoto Yuko Kitagawa |
| author_sort | Takuya Minagawa |
| collection | DOAJ |
| description | Surgical and oncological outcomes of hepatectomy for recurrent hepatocellular carcinoma (HCC) after locoregional therapy, including locally recurrent HCC (LR-HCC), were examined. Among 273 consecutive patients who underwent hepatectomy for HCC, 102 with recurrent HCC were included and retrospectively reviewed. There were 35 patients with recurrent HCC after primary hepatectomy and 67 with recurrent HCC after locoregional therapies. Pathologic review revealed 30 patients with LR-HCC. Background liver function was significantly worse in patients with recurrent HCC after locoregional therapy (<i>p</i> = 0.002). AFP (<i>p</i> = 0.031) and AFP-L3 (<i>p</i> = 0.033) serum levels were significantly higher in patients with LR-HCC. Perioperative morbidities were significantly more frequently observed with recurrent HCC after locoregional therapies (<i>p</i> = 0.048). Long-term outcomes of recurrent HCC after locoregional therapies were worse than those after hepatectomy, though there was no prognostic difference according to the recurrence patterns after locoregional therapies. Multivariate analyses showed that prognostic factors for resected recurrent HCC were previous locoregional therapy (hazard ratio [HR] 2.0; <i>p</i> = 0.005), multiple HCCs (HR 2.8; <i>p</i> < 0.001), and portal venous invasion (HR 2.3; <i>p</i> = 0.001). LR-HCC was not a prognostic factor. In conclusion, salvage hepatectomy for LR-HCC showed worse surgical outcomes but a favorable prognosis. |
| first_indexed | 2024-03-11T05:10:33Z |
| format | Article |
| id | doaj.art-e5bdc5e7a5804535a786868149229380 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:10:33Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e5bdc5e7a5804535a7868681492293802023-11-17T18:39:21ZengMDPI AGCancers2072-66942023-04-01158232010.3390/cancers15082320Surgical and Oncological Outcomes of Salvage Hepatectomy for Locally Recurrent Hepatocellular Carcinoma after Locoregional Therapy: A Single-Institution ExperienceTakuya Minagawa0Osamu Itano1Minoru Kitago2Yuta Abe3Hiroshi Yagi4Taizo Hibi5Masahiro Shinoda6Hidenori Ojima7Michiie Sakamoto8Yuko Kitagawa9Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, School of Medicine, International University of Health and Welfare, Chiba 286-0124, JapanDepartment of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, School of Medicine, International University of Health and Welfare, Chiba 286-0124, JapanDepartments of Surgery, Keio University School of Medicine, Tokyo 160-8582, JapanDepartments of Surgery, Keio University School of Medicine, Tokyo 160-8582, JapanDepartments of Surgery, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, JapanDepartment of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, School of Medicine, International University of Health and Welfare, Chiba 286-0124, JapanDepartments of Pathology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartments of Pathology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartments of Surgery, Keio University School of Medicine, Tokyo 160-8582, JapanSurgical and oncological outcomes of hepatectomy for recurrent hepatocellular carcinoma (HCC) after locoregional therapy, including locally recurrent HCC (LR-HCC), were examined. Among 273 consecutive patients who underwent hepatectomy for HCC, 102 with recurrent HCC were included and retrospectively reviewed. There were 35 patients with recurrent HCC after primary hepatectomy and 67 with recurrent HCC after locoregional therapies. Pathologic review revealed 30 patients with LR-HCC. Background liver function was significantly worse in patients with recurrent HCC after locoregional therapy (<i>p</i> = 0.002). AFP (<i>p</i> = 0.031) and AFP-L3 (<i>p</i> = 0.033) serum levels were significantly higher in patients with LR-HCC. Perioperative morbidities were significantly more frequently observed with recurrent HCC after locoregional therapies (<i>p</i> = 0.048). Long-term outcomes of recurrent HCC after locoregional therapies were worse than those after hepatectomy, though there was no prognostic difference according to the recurrence patterns after locoregional therapies. Multivariate analyses showed that prognostic factors for resected recurrent HCC were previous locoregional therapy (hazard ratio [HR] 2.0; <i>p</i> = 0.005), multiple HCCs (HR 2.8; <i>p</i> < 0.001), and portal venous invasion (HR 2.3; <i>p</i> = 0.001). LR-HCC was not a prognostic factor. In conclusion, salvage hepatectomy for LR-HCC showed worse surgical outcomes but a favorable prognosis.https://www.mdpi.com/2072-6694/15/8/2320hepatocellular carcinomasalvage hepatectomylocoregional therapyradiofrequency ablationtransarterial chemoembolizationlocal recurrence |
| spellingShingle | Takuya Minagawa Osamu Itano Minoru Kitago Yuta Abe Hiroshi Yagi Taizo Hibi Masahiro Shinoda Hidenori Ojima Michiie Sakamoto Yuko Kitagawa Surgical and Oncological Outcomes of Salvage Hepatectomy for Locally Recurrent Hepatocellular Carcinoma after Locoregional Therapy: A Single-Institution Experience Cancers hepatocellular carcinoma salvage hepatectomy locoregional therapy radiofrequency ablation transarterial chemoembolization local recurrence |
| title | Surgical and Oncological Outcomes of Salvage Hepatectomy for Locally Recurrent Hepatocellular Carcinoma after Locoregional Therapy: A Single-Institution Experience |
| title_full | Surgical and Oncological Outcomes of Salvage Hepatectomy for Locally Recurrent Hepatocellular Carcinoma after Locoregional Therapy: A Single-Institution Experience |
| title_fullStr | Surgical and Oncological Outcomes of Salvage Hepatectomy for Locally Recurrent Hepatocellular Carcinoma after Locoregional Therapy: A Single-Institution Experience |
| title_full_unstemmed | Surgical and Oncological Outcomes of Salvage Hepatectomy for Locally Recurrent Hepatocellular Carcinoma after Locoregional Therapy: A Single-Institution Experience |
| title_short | Surgical and Oncological Outcomes of Salvage Hepatectomy for Locally Recurrent Hepatocellular Carcinoma after Locoregional Therapy: A Single-Institution Experience |
| title_sort | surgical and oncological outcomes of salvage hepatectomy for locally recurrent hepatocellular carcinoma after locoregional therapy a single institution experience |
| topic | hepatocellular carcinoma salvage hepatectomy locoregional therapy radiofrequency ablation transarterial chemoembolization local recurrence |
| url | https://www.mdpi.com/2072-6694/15/8/2320 |
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