Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity
Foodborne mycotoxins are toxic metabolites that are produced by fungi. The widespread contamination of food and its by-products by mycotoxins is a global food safety problem that potentially threatens public health and other exposed animals. Most foodborne mycotoxins induce hepatotoxicity. However,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132200375X |
| _version_ | 1818248855876009984 |
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| author | Shunwang Zhao Jian Zhang Xueqian Sun Chamba Yangzom Peng Shang |
| author_facet | Shunwang Zhao Jian Zhang Xueqian Sun Chamba Yangzom Peng Shang |
| author_sort | Shunwang Zhao |
| collection | DOAJ |
| description | Foodborne mycotoxins are toxic metabolites that are produced by fungi. The widespread contamination of food and its by-products by mycotoxins is a global food safety problem that potentially threatens public health and other exposed animals. Most foodborne mycotoxins induce hepatotoxicity. However, only few studies have investigated the regulatory mechanisms of mitochondrial calcium transport monomers in mycotoxin-induced hepatotoxicity. Therefore, according to relevant studies and reports, this review suggests that intracellular Ca(2 +) homeostasis and mitochondrial Ca(2 +) uniporter are involved in the regulation of mycotoxin-induced hepatotoxicity. This review provides some ideas for future research involving mitochondrial Ca(2 +) uniporter in the molecular targets of mycotoxin-induced hepatotoxicity, as well as a reference for the research and development of related drugs and the treatment of related diseases. |
| first_indexed | 2024-12-12T15:27:14Z |
| format | Article |
| id | doaj.art-e5bdfaf16a4540f297d5ff01d1accaea |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-12T15:27:14Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-e5bdfaf16a4540f297d5ff01d1accaea2022-12-22T00:20:14ZengElsevierEcotoxicology and Environmental Safety0147-65132022-06-01237113535Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicityShunwang Zhao0Jian Zhang1Xueqian Sun2Chamba Yangzom3Peng Shang4College of Animal Science, Tibet Agriculture and Animal Husbandry College, Linzhi, Tibet, People’s Republic of China; The Provincial and Ministerial co-founded collaborative innovation center for R & D in Tibet characteristic Agricultural and Animal Husbandry resources, People's Republic of ChinaCollege of Animal Science, Tibet Agriculture and Animal Husbandry College, Linzhi, Tibet, People’s Republic of China; The Provincial and Ministerial co-founded collaborative innovation center for R & D in Tibet characteristic Agricultural and Animal Husbandry resources, People's Republic of ChinaCollege of Animal Science, Tibet Agriculture and Animal Husbandry College, Linzhi, Tibet, People’s Republic of China; The Provincial and Ministerial co-founded collaborative innovation center for R & D in Tibet characteristic Agricultural and Animal Husbandry resources, People's Republic of ChinaCollege of Animal Science, Tibet Agriculture and Animal Husbandry College, Linzhi, Tibet, People’s Republic of China; The Provincial and Ministerial co-founded collaborative innovation center for R & D in Tibet characteristic Agricultural and Animal Husbandry resources, People's Republic of ChinaCollege of Animal Science, Tibet Agriculture and Animal Husbandry College, Linzhi, Tibet, People’s Republic of China; The Provincial and Ministerial co-founded collaborative innovation center for R & D in Tibet characteristic Agricultural and Animal Husbandry resources, People's Republic of China; Correspondence to: College of Animal Science, Tibet Agriculture and Animal Husbandry College, Linzhi, Tibet, China.Foodborne mycotoxins are toxic metabolites that are produced by fungi. The widespread contamination of food and its by-products by mycotoxins is a global food safety problem that potentially threatens public health and other exposed animals. Most foodborne mycotoxins induce hepatotoxicity. However, only few studies have investigated the regulatory mechanisms of mitochondrial calcium transport monomers in mycotoxin-induced hepatotoxicity. Therefore, according to relevant studies and reports, this review suggests that intracellular Ca(2 +) homeostasis and mitochondrial Ca(2 +) uniporter are involved in the regulation of mycotoxin-induced hepatotoxicity. This review provides some ideas for future research involving mitochondrial Ca(2 +) uniporter in the molecular targets of mycotoxin-induced hepatotoxicity, as well as a reference for the research and development of related drugs and the treatment of related diseases.http://www.sciencedirect.com/science/article/pii/S014765132200375XMycotoxinHepatotoxicityMitochondrial Ca(2 +) uniporterMechanisms |
| spellingShingle | Shunwang Zhao Jian Zhang Xueqian Sun Chamba Yangzom Peng Shang Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity Ecotoxicology and Environmental Safety Mycotoxin Hepatotoxicity Mitochondrial Ca(2 +) uniporter Mechanisms |
| title | Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity |
| title_full | Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity |
| title_fullStr | Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity |
| title_full_unstemmed | Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity |
| title_short | Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity |
| title_sort | mitochondrial calcium uniporter involved in foodborne mycotoxin induced hepatotoxicity |
| topic | Mycotoxin Hepatotoxicity Mitochondrial Ca(2 +) uniporter Mechanisms |
| url | http://www.sciencedirect.com/science/article/pii/S014765132200375X |
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