Targeted Radiation Exposure Induces Accelerated Aortic Valve Remodeling in ApoE<sup>−/−</sup> Mice

Targeted Radiation Exposure Induces Accelerated Aortic Valve Remodeling in ApoE<sup>−/−</sup> Mice

Thoracic radiation therapy may result in accelerated atherosclerosis and in late aortic valve stenosis (AS). In this study, we assessed the feasibility of inducing radiation-induced AS using a targeted aortic valve irradiation (10 or 20 Grays) in two groups of C57Bl6/J (WT) and ApoE<sup>−/−<...

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Bibliographic Details
Main Authors: Guillaume Rucher, Kevin Prigent, Christophe Simard, Anne-Marie Frelin, Maëlle Coquemont-Guyot, Nicolas Elie, Nicolas Delcroix, Nicolas Perzo, Romain Guinamard, Ludovic Berger, Alain Manrique, on behalf of the STOP-AS Investigators
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Journal of Clinical Medicine
Subjects:
aortic stenosis
radiation therapy
mineralization
magnetic resonance imaging
Online Access:https://www.mdpi.com/2077-0383/12/18/5854

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