Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine Applications
Cell-based therapy in regenerative medicine is a powerful tool that can be used both to restore various cells lost in a wide range of human disorders and in renewal processes. Stem cells show promise for universal use in clinical medicine, potentially enabling the regeneration of numerous organs and...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/6/1587 |
| _version_ | 1797595993377603584 |
|---|---|
| author | Riccardo Ossanna Sheila Veronese Lindsey Alejandra Quintero Sierra Anita Conti Giamaica Conti Andrea Sbarbati |
| author_facet | Riccardo Ossanna Sheila Veronese Lindsey Alejandra Quintero Sierra Anita Conti Giamaica Conti Andrea Sbarbati |
| author_sort | Riccardo Ossanna |
| collection | DOAJ |
| description | Cell-based therapy in regenerative medicine is a powerful tool that can be used both to restore various cells lost in a wide range of human disorders and in renewal processes. Stem cells show promise for universal use in clinical medicine, potentially enabling the regeneration of numerous organs and tissues in the human body. This is possible due to their self-renewal, mature cell differentiation, and factors release. To date, pluripotent stem cells seem to be the most promising. Recently, a novel stem cell niche, called multilineage-differentiating stress-enduring (Muse) cells, is emerging. These cells are of particular interest because they are pluripotent and are found in adult human mesenchymal tissues. Thanks to this, they can produce cells representative of all three germ layers. Furthermore, they can be easily harvested from fat and isolated from the mesenchymal stem cells. This makes them very promising, allowing autologous treatments and avoiding the problems of rejection typical of transplants. Muse cells have recently been employed, with encouraging results, in numerous preclinical studies performed to test their efficacy in the treatment of various pathologies. This review aimed to (1) highlight the specific potential of Muse cells and provide a better understanding of this niche and (2) originate the first organized review of already tested applications of Muse cells in regenerative medicine. The obtained results could be useful to extend the possible therapeutic applications of disease healing. |
| first_indexed | 2024-03-11T02:45:14Z |
| format | Article |
| id | doaj.art-e5c2a127398c4c8fa4d4cf4d3198294d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T02:45:14Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e5c2a127398c4c8fa4d4cf4d3198294d2023-11-18T09:25:25ZengMDPI AGBiomedicines2227-90592023-05-01116158710.3390/biomedicines11061587Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine ApplicationsRiccardo Ossanna0Sheila Veronese1Lindsey Alejandra Quintero Sierra2Anita Conti3Giamaica Conti4Andrea Sbarbati5Department of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, 37124 Verona, ItalyDepartment of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, 37124 Verona, ItalyDepartment of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, 37124 Verona, ItalyDepartment of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, 37124 Verona, ItalyDepartment of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, 37124 Verona, ItalyDepartment of Neuroscience, Biomedicine, and Movement Sciences, University of Verona, 37124 Verona, ItalyCell-based therapy in regenerative medicine is a powerful tool that can be used both to restore various cells lost in a wide range of human disorders and in renewal processes. Stem cells show promise for universal use in clinical medicine, potentially enabling the regeneration of numerous organs and tissues in the human body. This is possible due to their self-renewal, mature cell differentiation, and factors release. To date, pluripotent stem cells seem to be the most promising. Recently, a novel stem cell niche, called multilineage-differentiating stress-enduring (Muse) cells, is emerging. These cells are of particular interest because they are pluripotent and are found in adult human mesenchymal tissues. Thanks to this, they can produce cells representative of all three germ layers. Furthermore, they can be easily harvested from fat and isolated from the mesenchymal stem cells. This makes them very promising, allowing autologous treatments and avoiding the problems of rejection typical of transplants. Muse cells have recently been employed, with encouraging results, in numerous preclinical studies performed to test their efficacy in the treatment of various pathologies. This review aimed to (1) highlight the specific potential of Muse cells and provide a better understanding of this niche and (2) originate the first organized review of already tested applications of Muse cells in regenerative medicine. The obtained results could be useful to extend the possible therapeutic applications of disease healing.https://www.mdpi.com/2227-9059/11/6/1587cell-based therapyregenerative medicinepluripotencymesenchymal stem cellsstromal vascular fraction |
| spellingShingle | Riccardo Ossanna Sheila Veronese Lindsey Alejandra Quintero Sierra Anita Conti Giamaica Conti Andrea Sbarbati Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine Applications Biomedicines cell-based therapy regenerative medicine pluripotency mesenchymal stem cells stromal vascular fraction |
| title | Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine Applications |
| title_full | Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine Applications |
| title_fullStr | Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine Applications |
| title_full_unstemmed | Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine Applications |
| title_short | Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): An Easily Accessible, Pluripotent Stem Cell Niche with Unique and Powerful Properties for Multiple Regenerative Medicine Applications |
| title_sort | multilineage differentiating stress enduring cells muse cells an easily accessible pluripotent stem cell niche with unique and powerful properties for multiple regenerative medicine applications |
| topic | cell-based therapy regenerative medicine pluripotency mesenchymal stem cells stromal vascular fraction |
| url | https://www.mdpi.com/2227-9059/11/6/1587 |
| work_keys_str_mv | AT riccardoossanna multilineagedifferentiatingstressenduringcellsmusecellsaneasilyaccessiblepluripotentstemcellnichewithuniqueandpowerfulpropertiesformultipleregenerativemedicineapplications AT sheilaveronese multilineagedifferentiatingstressenduringcellsmusecellsaneasilyaccessiblepluripotentstemcellnichewithuniqueandpowerfulpropertiesformultipleregenerativemedicineapplications AT lindseyalejandraquinterosierra multilineagedifferentiatingstressenduringcellsmusecellsaneasilyaccessiblepluripotentstemcellnichewithuniqueandpowerfulpropertiesformultipleregenerativemedicineapplications AT anitaconti multilineagedifferentiatingstressenduringcellsmusecellsaneasilyaccessiblepluripotentstemcellnichewithuniqueandpowerfulpropertiesformultipleregenerativemedicineapplications AT giamaicaconti multilineagedifferentiatingstressenduringcellsmusecellsaneasilyaccessiblepluripotentstemcellnichewithuniqueandpowerfulpropertiesformultipleregenerativemedicineapplications AT andreasbarbati multilineagedifferentiatingstressenduringcellsmusecellsaneasilyaccessiblepluripotentstemcellnichewithuniqueandpowerfulpropertiesformultipleregenerativemedicineapplications |