Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study
Background Characterizing associations of sleep characteristics with blood‐glucose–level factors among blacks may clarify the underlying mechanisms of impaired glucose metabolism and help identify treatment targets to prevent diabetes mellitus in blacks. Methods and Results Cross‐sectional analyses...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-05-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.013209 |
| _version_ | 1811332419997925376 |
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| author | Yuichiro Yano Yan Gao Dayna A. Johnson Mercedes Carnethon Adolfo Correa Murray A. Mittleman Mario Sims Elizabeth Mostofsky James G. Wilson Susan Redline |
| author_facet | Yuichiro Yano Yan Gao Dayna A. Johnson Mercedes Carnethon Adolfo Correa Murray A. Mittleman Mario Sims Elizabeth Mostofsky James G. Wilson Susan Redline |
| author_sort | Yuichiro Yano |
| collection | DOAJ |
| description | Background Characterizing associations of sleep characteristics with blood‐glucose–level factors among blacks may clarify the underlying mechanisms of impaired glucose metabolism and help identify treatment targets to prevent diabetes mellitus in blacks. Methods and Results Cross‐sectional analyses were conducted in 789 blacks who completed home sleep apnea testing and 7‐day wrist actigraphy in 2012–2016. Sleep‐disordered breathing measurements included respiratory event index associated with 4% oxygen desaturation and minimum oxygen saturation. Sleep patterns on actigraphy included fragmented sleep indices. Associations between sleep characteristics (8 exposures) and measures of glucose metabolism (3 outcomes) were determined using multivariable linear regression. Mean (SD) age of the participants was 63 (11) years; 581 (74%) were women; 198 (25%) were diabetes mellitus, and 158 (20%) were taking antihyperglycemic medication. After multivariable adjustment, including antihyperglycemic medication use, the betas (95% CI) for fasting glucose and hemoglobin A1c, respectively, for each SD higher level were 0.13 (0.02, 0.24) mmol/L and 1.11 (0.42, 1.79) mmol/mol for respiratory event index associated with 4% oxygen desaturation and 0.16 (0.05, 0.27) mmol/L and 0.77 (0.10, 1.43) mmol/mol for fragmented sleep indices. Among 589 participants without diabetes mellitus, the betas (95% CI) for homeostatic model assessment of insulin resistance for each SD higher level were 1.09 (1.03, 1.16) for respiratory event index associated with 4% oxygen desaturation, 0.90 (0.85, 0.96) for minimum oxygen saturation, and 1.07 (1.01, 1.13) for fragmented sleep indices. Conclusions Sleep‐disordered breathing, overnight hypoxemia, and sleep fragmentation were associated with higher blood glucose levels among blacks. |
| first_indexed | 2024-04-13T16:36:40Z |
| format | Article |
| id | doaj.art-e5c3cce16690446f838cc8dd055bb650 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:36:40Z |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-e5c3cce16690446f838cc8dd055bb6502022-12-22T02:39:25ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-05-019910.1161/JAHA.119.013209Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart StudyYuichiro Yano0Yan Gao1Dayna A. Johnson2Mercedes Carnethon3Adolfo Correa4Murray A. Mittleman5Mario Sims6Elizabeth Mostofsky7James G. Wilson8Susan Redline9Department of Family Medicine and Community Health Duke University Durham NCDepartment of Physiology and Biophysics University of Mississippi Medical Center Jackson MSDivision of Sleep and Circadian Disorders Brigham and Women’s Hospital Boston MADepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago ILDepartments of Pediatrics and Medicine University of Mississippi Medical Center Jackson MSDepartment of Epidemiology Harvard T.H. Chan School 12 of Public Health Boston MADepartments of Pediatrics and Medicine University of Mississippi Medical Center Jackson MSDepartment of Epidemiology Harvard T.H. Chan School 12 of Public Health Boston MADepartment of Physiology and Biophysics University of Mississippi Medical Center Jackson MSDivision of Sleep and Circadian Disorders Brigham and Women’s Hospital Boston MABackground Characterizing associations of sleep characteristics with blood‐glucose–level factors among blacks may clarify the underlying mechanisms of impaired glucose metabolism and help identify treatment targets to prevent diabetes mellitus in blacks. Methods and Results Cross‐sectional analyses were conducted in 789 blacks who completed home sleep apnea testing and 7‐day wrist actigraphy in 2012–2016. Sleep‐disordered breathing measurements included respiratory event index associated with 4% oxygen desaturation and minimum oxygen saturation. Sleep patterns on actigraphy included fragmented sleep indices. Associations between sleep characteristics (8 exposures) and measures of glucose metabolism (3 outcomes) were determined using multivariable linear regression. Mean (SD) age of the participants was 63 (11) years; 581 (74%) were women; 198 (25%) were diabetes mellitus, and 158 (20%) were taking antihyperglycemic medication. After multivariable adjustment, including antihyperglycemic medication use, the betas (95% CI) for fasting glucose and hemoglobin A1c, respectively, for each SD higher level were 0.13 (0.02, 0.24) mmol/L and 1.11 (0.42, 1.79) mmol/mol for respiratory event index associated with 4% oxygen desaturation and 0.16 (0.05, 0.27) mmol/L and 0.77 (0.10, 1.43) mmol/mol for fragmented sleep indices. Among 589 participants without diabetes mellitus, the betas (95% CI) for homeostatic model assessment of insulin resistance for each SD higher level were 1.09 (1.03, 1.16) for respiratory event index associated with 4% oxygen desaturation, 0.90 (0.85, 0.96) for minimum oxygen saturation, and 1.07 (1.01, 1.13) for fragmented sleep indices. Conclusions Sleep‐disordered breathing, overnight hypoxemia, and sleep fragmentation were associated with higher blood glucose levels among blacks.https://www.ahajournals.org/doi/10.1161/JAHA.119.013209blacksglucose metabolismsleep |
| spellingShingle | Yuichiro Yano Yan Gao Dayna A. Johnson Mercedes Carnethon Adolfo Correa Murray A. Mittleman Mario Sims Elizabeth Mostofsky James G. Wilson Susan Redline Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease blacks glucose metabolism sleep |
| title | Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study |
| title_full | Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study |
| title_fullStr | Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study |
| title_full_unstemmed | Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study |
| title_short | Sleep Characteristics and Measures of Glucose Metabolism in Blacks: The Jackson Heart Study |
| title_sort | sleep characteristics and measures of glucose metabolism in blacks the jackson heart study |
| topic | blacks glucose metabolism sleep |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.013209 |
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