Immunohistochemical expression of HER2/neu in colorectal carcinoma in Erbil city, Kurdistan Region
Background and objective: Colorectal carcinoma is one of the commonest cancers and the second leading cause of cancer death in Europe and North America. Despite the improved surgeries and adjuvant therapies, the prognosis of colorectal cancer remains poor, and the survival rate is unsatisfactory. Ov...
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| Format: | Article |
| Language: | English |
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Hawler Medical University
2019-12-01
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| Series: | Zanco Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://zjms.hmu.edu.krd/index.php/zjms/article/view/734/614 |
| _version_ | 1818179998434983936 |
|---|---|
| author | Lilav Adel Kamal Jalal Ali Jalal |
| author_facet | Lilav Adel Kamal Jalal Ali Jalal |
| author_sort | Lilav Adel Kamal |
| collection | DOAJ |
| description | Background and objective: Colorectal carcinoma is one of the commonest cancers and the second leading cause of cancer death in Europe and North America. Despite the improved surgeries and adjuvant therapies, the prognosis of colorectal cancer remains poor, and the survival rate is unsatisfactory. Overexpression of HER2 gene has been noticed in many human cancers, and it is associated with poor prognosis. This study aimed to detect the frequency of the HER2/neu immunoexpression in colorectal carcinoma and investigate its association with the clinicopathological parameters.
Methods: A retrospective study was carried out in Rizgary teaching hospital and private laboratories in Erbil city for the period from January 2014 - December 2017. A total of 103 formalin fixed, paraffin embedded, archival tissue blocks of colectomy samples of colorectal carcinoma cases were collected. Immunostaining was done in a private laboratory (Vin Lab) in Dohuk city. Scoring of the HER2/neu immunostaining was managed according to published criteria for breast carcinoma.
Results: Fifty-five cases (53.4%) were labeled as positive for HER2/neuimmunoexpression. While 48 (46.6%) of the cases were labeled as negative. HER2/neu status was significantly associated with the tumor grade (P = 0.02), while no significant association was found between HER2/neu expression and other clinicopathological parameters.
Conclusion: HER2/neu immunoexpression was observed in 53.4% of the cases of colorectal carcinoma, and it was significantly associated with tumor grade. |
| first_indexed | 2024-12-11T21:12:47Z |
| format | Article |
| id | doaj.art-e5c5764ba0a142cfae2fa90f271ad0ed |
| institution | Directory Open Access Journal |
| issn | 1995-5588 1995-5596 |
| language | English |
| last_indexed | 2024-12-11T21:12:47Z |
| publishDate | 2019-12-01 |
| publisher | Hawler Medical University |
| record_format | Article |
| series | Zanco Journal of Medical Sciences |
| spelling | doaj.art-e5c5764ba0a142cfae2fa90f271ad0ed2022-12-22T00:50:40ZengHawler Medical UniversityZanco Journal of Medical Sciences1995-55881995-55962019-12-0123342142810.15218/zjms.2019.052Immunohistochemical expression of HER2/neu in colorectal carcinoma in Erbil city, Kurdistan RegionLilav Adel Kamal0Jalal Ali Jalal 1Rizgary Teaching HospitalHawler Medical UniversityBackground and objective: Colorectal carcinoma is one of the commonest cancers and the second leading cause of cancer death in Europe and North America. Despite the improved surgeries and adjuvant therapies, the prognosis of colorectal cancer remains poor, and the survival rate is unsatisfactory. Overexpression of HER2 gene has been noticed in many human cancers, and it is associated with poor prognosis. This study aimed to detect the frequency of the HER2/neu immunoexpression in colorectal carcinoma and investigate its association with the clinicopathological parameters. Methods: A retrospective study was carried out in Rizgary teaching hospital and private laboratories in Erbil city for the period from January 2014 - December 2017. A total of 103 formalin fixed, paraffin embedded, archival tissue blocks of colectomy samples of colorectal carcinoma cases were collected. Immunostaining was done in a private laboratory (Vin Lab) in Dohuk city. Scoring of the HER2/neu immunostaining was managed according to published criteria for breast carcinoma. Results: Fifty-five cases (53.4%) were labeled as positive for HER2/neuimmunoexpression. While 48 (46.6%) of the cases were labeled as negative. HER2/neu status was significantly associated with the tumor grade (P = 0.02), while no significant association was found between HER2/neu expression and other clinicopathological parameters. Conclusion: HER2/neu immunoexpression was observed in 53.4% of the cases of colorectal carcinoma, and it was significantly associated with tumor grade.https://zjms.hmu.edu.krd/index.php/zjms/article/view/734/614colorectal carcinomaher2/neuimmunoexpression |
| spellingShingle | Lilav Adel Kamal Jalal Ali Jalal Immunohistochemical expression of HER2/neu in colorectal carcinoma in Erbil city, Kurdistan Region Zanco Journal of Medical Sciences colorectal carcinoma her2/neu immunoexpression |
| title | Immunohistochemical expression of HER2/neu in colorectal carcinoma in Erbil city, Kurdistan Region |
| title_full | Immunohistochemical expression of HER2/neu in colorectal carcinoma in Erbil city, Kurdistan Region |
| title_fullStr | Immunohistochemical expression of HER2/neu in colorectal carcinoma in Erbil city, Kurdistan Region |
| title_full_unstemmed | Immunohistochemical expression of HER2/neu in colorectal carcinoma in Erbil city, Kurdistan Region |
| title_short | Immunohistochemical expression of HER2/neu in colorectal carcinoma in Erbil city, Kurdistan Region |
| title_sort | immunohistochemical expression of her2 neu in colorectal carcinoma in erbil city kurdistan region |
| topic | colorectal carcinoma her2/neu immunoexpression |
| url | https://zjms.hmu.edu.krd/index.php/zjms/article/view/734/614 |
| work_keys_str_mv | AT lilavadelkamal immunohistochemicalexpressionofher2neuincolorectalcarcinomainerbilcitykurdistanregion AT jalalalijalal immunohistochemicalexpressionofher2neuincolorectalcarcinomainerbilcitykurdistanregion |