A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrils
Abstract Alzheimer’s disease (AD) is a neurological disorder in which the neuronal degeneration is associated with inflammatory processes and oxidative stress. Since alpha-terpineol was shown to possess antioxidant and anti-inflammatory effects, the administration of this compound was studied on a r...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2022-05-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100563&tlng=en |
| _version_ | 1828261581380648960 |
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| author | Hamid-Reza Alipour Parichehreh Yaghmaei Shahin Ahmadian Maryam Ghobeh Azadeh Ebrahim-Habibi |
| author_facet | Hamid-Reza Alipour Parichehreh Yaghmaei Shahin Ahmadian Maryam Ghobeh Azadeh Ebrahim-Habibi |
| author_sort | Hamid-Reza Alipour |
| collection | DOAJ |
| description | Abstract Alzheimer’s disease (AD) is a neurological disorder in which the neuronal degeneration is associated with inflammatory processes and oxidative stress. Since alpha-terpineol was shown to possess antioxidant and anti-inflammatory effects, the administration of this compound was studied on a rat model of AD. To create this model, Aβ1-42 was injected into the hippocampus of male Wistar rats. Generated AD models were divided into simple AD models and AD models in which short-term immobilization stress was added. Preventive and therapeutic (post-AD induction) effects of alpha-terpineol consumption (100 mg/Kg) were subsequently investigated in AD models, which were compared with control groups. Biochemical factors (superoxide dismutase and malondialdehyde), histological manifestations (amyloid plaques and neuron counts) and possible memory impairment (shuttle-box experiment) were investigated in all groups. For the in vitro experiment, alpha-terpineol effect was checked on Aβ1-42 fibril formation. In preventive and therapeutic modes, alpha-terpineol consumption could improve neurogenesis and long-term memory while reducing amyloid plaque counts and ameliorating biochemical factors (higher levels of superoxide dismutase and malondialdehyde and reduced levels of MDA). In vitro, shorter fibrillar structures were formed in the presence of alpha-terpineol, which indicates an anti-amyloid effect for this compound. In conclusion, alpha-terpineol significantly counteracted AD consequences. |
| first_indexed | 2024-04-13T03:41:52Z |
| format | Article |
| id | doaj.art-e5c62d4bc8fc4f2e8375998cd5e218a9 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-13T03:41:52Z |
| publishDate | 2022-05-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-e5c62d4bc8fc4f2e8375998cd5e218a92022-12-22T03:04:07ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902022-05-015810.1590/s2175-97902022e19090A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrilsHamid-Reza AlipourParichehreh Yaghmaeihttps://orcid.org/0000-0003-3071-666XShahin AhmadianMaryam Ghobehhttps://orcid.org/0000-0002-5038-5426Azadeh Ebrahim-HabibiAbstract Alzheimer’s disease (AD) is a neurological disorder in which the neuronal degeneration is associated with inflammatory processes and oxidative stress. Since alpha-terpineol was shown to possess antioxidant and anti-inflammatory effects, the administration of this compound was studied on a rat model of AD. To create this model, Aβ1-42 was injected into the hippocampus of male Wistar rats. Generated AD models were divided into simple AD models and AD models in which short-term immobilization stress was added. Preventive and therapeutic (post-AD induction) effects of alpha-terpineol consumption (100 mg/Kg) were subsequently investigated in AD models, which were compared with control groups. Biochemical factors (superoxide dismutase and malondialdehyde), histological manifestations (amyloid plaques and neuron counts) and possible memory impairment (shuttle-box experiment) were investigated in all groups. For the in vitro experiment, alpha-terpineol effect was checked on Aβ1-42 fibril formation. In preventive and therapeutic modes, alpha-terpineol consumption could improve neurogenesis and long-term memory while reducing amyloid plaque counts and ameliorating biochemical factors (higher levels of superoxide dismutase and malondialdehyde and reduced levels of MDA). In vitro, shorter fibrillar structures were formed in the presence of alpha-terpineol, which indicates an anti-amyloid effect for this compound. In conclusion, alpha-terpineol significantly counteracted AD consequences.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100563&tlng=enAmyloid plaquesAβ42Alpha-terpineolMemoryMovement |
| spellingShingle | Hamid-Reza Alipour Parichehreh Yaghmaei Shahin Ahmadian Maryam Ghobeh Azadeh Ebrahim-Habibi A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrils Brazilian Journal of Pharmaceutical Sciences Amyloid plaques Aβ42 Alpha-terpineol Memory Movement |
| title | A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrils |
| title_full | A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrils |
| title_fullStr | A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrils |
| title_full_unstemmed | A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrils |
| title_short | A study on alpha-terpineol in Alzheimer’s disease with the use of rodent in vivo model, restraint stress effect and in vitro Amyloid beta fibrils |
| title_sort | study on alpha terpineol in alzheimer s disease with the use of rodent in vivo model restraint stress effect and in vitro amyloid beta fibrils |
| topic | Amyloid plaques Aβ42 Alpha-terpineol Memory Movement |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100563&tlng=en |
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