The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer
PURPOSEThe correlation between imaging findings and pathologic characteristics of tumors may provide information for diagnosis and treatment of cancer. The aim of this study is to determine whether ultrasound features of breast cancer are associated with molecular subtype, histologic grade, and horm...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-11-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/the-role-of-ultrasonographic-findings-to-predict-m/55602
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| _version_ | 1827823334131236864 |
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| author | Filiz Çelebi Kezban Nur Pilancı Çetin Ordu Filiz Ağacayak Gül Alço Serkan İlgün Dauren Sarsenov Zeynep Erdoğan Vahit Özmen |
| author_facet | Filiz Çelebi Kezban Nur Pilancı Çetin Ordu Filiz Ağacayak Gül Alço Serkan İlgün Dauren Sarsenov Zeynep Erdoğan Vahit Özmen |
| author_sort | Filiz Çelebi |
| collection | DOAJ |
| description | PURPOSEThe correlation between imaging findings and pathologic characteristics of tumors may provide information for diagnosis and treatment of cancer. The aim of this study is to determine whether ultrasound features of breast cancer are associated with molecular subtype, histologic grade, and hormone receptor status, as well as assess the predictive value of these features.METHODSA total of 201 consecutive invasive breast cancer patients were reviewed from the database according to the Breast Imaging and Reporting Data System (BI-RADS). Tumor margins were classified as circumscribed and noncircumscribed. Noncircumscribed group was divided into indistinct, spiculated, angular, and microlobulated. The posterior acoustic features were divided into four categories: shadowing, enhancement, no change, and mixed pattern.RESULTSTumors with posterior shadowing were more likely to be of nontriple negative subtype (odds ratio [OR], 7.42; 95% CI, 2.10–24.99; P = 0.002), low histologic grade (grade 1 or 2 vs. grade 3: OR, 2.42; 95% CI, 1.34–4.35; P = 0.003) and having at least one positive receptor (OR, 3.36; 95% CI, 1.55–7.26; P = 0.002). Tumors with circumscribed margins were more often triple-negative subtype (OR, 6.72; 95% CI, 2.56–17.65; P < 0.001), high grade (grade 3 vs. grade 1 or 2: OR, 5.42; 95% CI, 2.66–11.00; P < 0.001) and hormone receptor negative (OR, 4.87; 95% CI, 2.37–9.99; P < 0.001).CONCLUSIONSonographic features are strongly associated with molecular subtype, histologic grade, and hormone receptor status of the tumor. These findings may separate triple-negative breast cancer from other molecular subtypes. |
| first_indexed | 2024-03-12T02:10:37Z |
| format | Article |
| id | doaj.art-e5c7c00d6e5846e6869870059e0b4847 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:10:37Z |
| publishDate | 2015-11-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-e5c7c00d6e5846e6869870059e0b48472023-09-06T13:45:16ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122015-11-0121644845310.5152/dir.2015.1451513049054The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancerFiliz Çelebi0Kezban Nur Pilancı1Çetin Ordu2Filiz Ağacayak3Gül Alço4Serkan İlgün5Dauren Sarsenov6Zeynep Erdoğan7Vahit Özmen8 Department of Radiology, Florence Nightingale Hospital, İstanbul, Turkey Department of Oncology, İstanbul Bilim University, İstanbul, Turkey Department of Oncology, İstanbul Bilim University, İstanbul, Turkey Department of Radiology, Florence Nightingale Hospital, İstanbul, Turkey Department of Radiation Oncology, Florence Nightingale Hospital, İstanbul, Turkey Department of General Surgery, Florence Nightingale Hospital, İstanbul, Turkey Department of General Surgery, Florence Nightingale Hospital, İstanbul, Turkey Department of Physical Therapy and Rehabilitation, İstanbul Bilim University, İstanbul, Turkey Department of General Surgery, Florence Nightingale Hospital, İstanbul, Turkey PURPOSEThe correlation between imaging findings and pathologic characteristics of tumors may provide information for diagnosis and treatment of cancer. The aim of this study is to determine whether ultrasound features of breast cancer are associated with molecular subtype, histologic grade, and hormone receptor status, as well as assess the predictive value of these features.METHODSA total of 201 consecutive invasive breast cancer patients were reviewed from the database according to the Breast Imaging and Reporting Data System (BI-RADS). Tumor margins were classified as circumscribed and noncircumscribed. Noncircumscribed group was divided into indistinct, spiculated, angular, and microlobulated. The posterior acoustic features were divided into four categories: shadowing, enhancement, no change, and mixed pattern.RESULTSTumors with posterior shadowing were more likely to be of nontriple negative subtype (odds ratio [OR], 7.42; 95% CI, 2.10–24.99; P = 0.002), low histologic grade (grade 1 or 2 vs. grade 3: OR, 2.42; 95% CI, 1.34–4.35; P = 0.003) and having at least one positive receptor (OR, 3.36; 95% CI, 1.55–7.26; P = 0.002). Tumors with circumscribed margins were more often triple-negative subtype (OR, 6.72; 95% CI, 2.56–17.65; P < 0.001), high grade (grade 3 vs. grade 1 or 2: OR, 5.42; 95% CI, 2.66–11.00; P < 0.001) and hormone receptor negative (OR, 4.87; 95% CI, 2.37–9.99; P < 0.001).CONCLUSIONSonographic features are strongly associated with molecular subtype, histologic grade, and hormone receptor status of the tumor. These findings may separate triple-negative breast cancer from other molecular subtypes. http://www.dirjournal.org/archives/archive-detail/article-preview/the-role-of-ultrasonographic-findings-to-predict-m/55602 |
| spellingShingle | Filiz Çelebi Kezban Nur Pilancı Çetin Ordu Filiz Ağacayak Gül Alço Serkan İlgün Dauren Sarsenov Zeynep Erdoğan Vahit Özmen The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer Diagnostic and Interventional Radiology |
| title | The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer |
| title_full | The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer |
| title_fullStr | The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer |
| title_full_unstemmed | The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer |
| title_short | The role of ultrasonographic findings to predict molecular subtype, histologic grade, and hormone receptor status of breast cancer |
| title_sort | role of ultrasonographic findings to predict molecular subtype histologic grade and hormone receptor status of breast cancer |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/the-role-of-ultrasonographic-findings-to-predict-m/55602
|
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