EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases
Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and ot...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-06-01
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| Series: | Romanian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/rjim-2023-0008 |
| _version_ | 1797816697311199232 |
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| author | Pop Ruxandra Mihaela Diaconu Claudia Irina Rimbaş Mihai Mateescu Radu Bogdan Rouhani Farid Popp Cristiana Manfrin Erminia Crinò Stefano Francesco Cauni Victor |
| author_facet | Pop Ruxandra Mihaela Diaconu Claudia Irina Rimbaş Mihai Mateescu Radu Bogdan Rouhani Farid Popp Cristiana Manfrin Erminia Crinò Stefano Francesco Cauni Victor |
| author_sort | Pop Ruxandra Mihaela |
| collection | DOAJ |
| description | Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis. |
| first_indexed | 2024-03-13T08:42:31Z |
| format | Article |
| id | doaj.art-e5c7f00d1f704b23a1107d5fa011205e |
| institution | Directory Open Access Journal |
| issn | 2501-062X |
| language | English |
| last_indexed | 2024-03-13T08:42:31Z |
| publishDate | 2023-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Internal Medicine |
| spelling | doaj.art-e5c7f00d1f704b23a1107d5fa011205e2023-05-30T09:15:21ZengSciendoRomanian Journal of Internal Medicine2501-062X2023-06-0161211612410.2478/rjim-2023-0008EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two casesPop Ruxandra Mihaela0Diaconu Claudia Irina1Rimbaş Mihai2Mateescu Radu Bogdan3Rouhani Farid4Popp Cristiana5Manfrin Erminia6Crinò Stefano Francesco7Cauni Victor81Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19–21 Stefan cel Mare, 020125, Romania1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19–21 Stefan cel Mare, 020125, Romania1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19–21 Stefan cel Mare, 020125, Romania1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19–21 Stefan cel Mare, 020125, Romania1Gastroenterology Department, Colentina Clinical Hospital, Bucharest, District 2, 19–21 Stefan cel Mare, 020125, Romania3Department of Pathology, Colentina Clinical Hospital, Bucharest, District 2, 19–21 Stefan cel Mare, 020125, Romania4Department of Diagnostics and Public Health, Section of Pathology, University of Verona, 10 Piazzale Ludovico Antonio Scuro, 37124, Verona, Italy5Digestive Endoscopy Unit, The Pancreas Institute, G.B. Rossi University Hospital, 10 Piazzale LA Scuro, 37126, Verona, Italy6Urology Department, Colentina Clinical Hospital, Bucharest, District 2, 19–21 Stefan cel Mare street, 020125, RomaniaUndifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.https://doi.org/10.2478/rjim-2023-0008endoscopic ultrasound-guided fine needle aspirationendoscopic ultrasound-guided fine needle biopsyimmunohistochemistryosteoclast-like giant cellpancreatic cancertumor markers |
| spellingShingle | Pop Ruxandra Mihaela Diaconu Claudia Irina Rimbaş Mihai Mateescu Radu Bogdan Rouhani Farid Popp Cristiana Manfrin Erminia Crinò Stefano Francesco Cauni Victor EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases Romanian Journal of Internal Medicine endoscopic ultrasound-guided fine needle aspiration endoscopic ultrasound-guided fine needle biopsy immunohistochemistry osteoclast-like giant cell pancreatic cancer tumor markers |
| title | EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases |
| title_full | EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases |
| title_fullStr | EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases |
| title_full_unstemmed | EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases |
| title_short | EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases |
| title_sort | eus guided fine needle biopsy is able to provide diagnosis in rare osteoclast like giant cells undifferentiated carcinoma of the pancreas report of two cases |
| topic | endoscopic ultrasound-guided fine needle aspiration endoscopic ultrasound-guided fine needle biopsy immunohistochemistry osteoclast-like giant cell pancreatic cancer tumor markers |
| url | https://doi.org/10.2478/rjim-2023-0008 |
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