Multicomponent Agents for Prevention and Treatment of Digestive Diseases
Introduction. In recent years, there has been a steady increase in gastroenterological diseases in many countries due to adverse environmental conditions and unsustainable nutrition. Diseases of digestive organs are not only chronic, but also combined, and varieties of synthetic drugs are widely use...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2020-08-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/819 |
| _version_ | 1797874995622313984 |
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| author | E. V. Ferubko |
| author_facet | E. V. Ferubko |
| author_sort | E. V. Ferubko |
| collection | DOAJ |
| description | Introduction. In recent years, there has been a steady increase in gastroenterological diseases in many countries due to adverse environmental conditions and unsustainable nutrition. Diseases of digestive organs are not only chronic, but also combined, and varieties of synthetic drugs are widely used in therapy. The range of official multicomponent plant collections recommended in the therapy of diseases of the digestive system is limited, and their disadvantage is especially felt in the treatment of chronic hepatitis, gastric ulcer, cholecystitis.Aim. Search and creation of new multicomponent agents for prevention and complex treatment of digestive system diseases.Materials and methods. The objects of the study were developed multi-component means: «Pentafit», «Octafit», «Hexafit». To assess the pharmacotherapeutic effect of the developed agents «Pentafit» hepatoprotective activity studied in experimental models tetrachloromethane and D-galactosamine hepatitis, «Octafit» gastroprotective activity studied in models of acute aspirins, neurogenic and chronic butadione ulcer, сholeretic activity of «Hexafit» as studied in models of experimental cholecystitis and toxic liver damage using laboratory animals. The results of the studies processed statistically using the Statistica 10 program.Results and discussion. Based on the obtained data, the general patterns in molecular biological action of the studied multicomponent agents revealed, which consist in their ability to inhibit the free radical oxidation of lipids and stabilize the biological membranes of gastric cells and organs of the hepatobiliary system. «Pentafit» profitably distinguished by its multilateral nature of influence on the functional state and structure of the organs of the liver. «Octafit» provides accelerated healing and restoration of damaged structures of functional systems of the stomach. «Hexafit» secreted by the polyvalent spectrum of action in case of damage to the hepatobiliary system.Conclusion. Developed multicomponent drugs will expand the register of medicines of plant origin of domestic production for the prevention and treatment of digestive diseases. |
| first_indexed | 2024-04-10T01:39:41Z |
| format | Article |
| id | doaj.art-e5ca1634697c412e8304a4b429887753 |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:39:41Z |
| publishDate | 2020-08-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-e5ca1634697c412e8304a4b4298877532023-03-13T09:14:01ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492020-08-0193152010.33380/2305-2066-2020-9-3-15-20765Multicomponent Agents for Prevention and Treatment of Digestive DiseasesE. V. Ferubko0ФГБНУ «Всероссийский научно-исследовательский институт лекарственных и ароматических растений» (ВИЛАР)Introduction. In recent years, there has been a steady increase in gastroenterological diseases in many countries due to adverse environmental conditions and unsustainable nutrition. Diseases of digestive organs are not only chronic, but also combined, and varieties of synthetic drugs are widely used in therapy. The range of official multicomponent plant collections recommended in the therapy of diseases of the digestive system is limited, and their disadvantage is especially felt in the treatment of chronic hepatitis, gastric ulcer, cholecystitis.Aim. Search and creation of new multicomponent agents for prevention and complex treatment of digestive system diseases.Materials and methods. The objects of the study were developed multi-component means: «Pentafit», «Octafit», «Hexafit». To assess the pharmacotherapeutic effect of the developed agents «Pentafit» hepatoprotective activity studied in experimental models tetrachloromethane and D-galactosamine hepatitis, «Octafit» gastroprotective activity studied in models of acute aspirins, neurogenic and chronic butadione ulcer, сholeretic activity of «Hexafit» as studied in models of experimental cholecystitis and toxic liver damage using laboratory animals. The results of the studies processed statistically using the Statistica 10 program.Results and discussion. Based on the obtained data, the general patterns in molecular biological action of the studied multicomponent agents revealed, which consist in their ability to inhibit the free radical oxidation of lipids and stabilize the biological membranes of gastric cells and organs of the hepatobiliary system. «Pentafit» profitably distinguished by its multilateral nature of influence on the functional state and structure of the organs of the liver. «Octafit» provides accelerated healing and restoration of damaged structures of functional systems of the stomach. «Hexafit» secreted by the polyvalent spectrum of action in case of damage to the hepatobiliary system.Conclusion. Developed multicomponent drugs will expand the register of medicines of plant origin of domestic production for the prevention and treatment of digestive diseases.https://www.pharmjournal.ru/jour/article/view/819многокомпонентные растительные экстрактыдоклинические исследованиятоксические модели повреждений печени и желчного пузыряэкспериментальные язвы желудкалабораторные животныеперекисное окисление липидовболезни пищеварительной системы |
| spellingShingle | E. V. Ferubko Multicomponent Agents for Prevention and Treatment of Digestive Diseases Разработка и регистрация лекарственных средств многокомпонентные растительные экстракты доклинические исследования токсические модели повреждений печени и желчного пузыря экспериментальные язвы желудка лабораторные животные перекисное окисление липидов болезни пищеварительной системы |
| title | Multicomponent Agents for Prevention and Treatment of Digestive Diseases |
| title_full | Multicomponent Agents for Prevention and Treatment of Digestive Diseases |
| title_fullStr | Multicomponent Agents for Prevention and Treatment of Digestive Diseases |
| title_full_unstemmed | Multicomponent Agents for Prevention and Treatment of Digestive Diseases |
| title_short | Multicomponent Agents for Prevention and Treatment of Digestive Diseases |
| title_sort | multicomponent agents for prevention and treatment of digestive diseases |
| topic | многокомпонентные растительные экстракты доклинические исследования токсические модели повреждений печени и желчного пузыря экспериментальные язвы желудка лабораторные животные перекисное окисление липидов болезни пищеварительной системы |
| url | https://www.pharmjournal.ru/jour/article/view/819 |
| work_keys_str_mv | AT evferubko multicomponentagentsforpreventionandtreatmentofdigestivediseases |