Evaluating the renoprotective effectiveness of sodium-glucose co-transporter 2 inhibitor therapy in patients with chronic kidney disease: A prospective study
Background/Aim. Chronic kidney disease (CKD) is a global health concern associated with increased cardio-vascular risks and premature mortality. Proteinuria is a key prognostic indicator for CKD outcome. Sodium-glucose cotransporter 2 (SGLT2) inhibitors show potential for reducing proteinuria and sl...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2024-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502300061K.pdf |
| _version_ | 1797215458601992192 |
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| author | Karadžić-Ristanović Vidna Gajić Selena Bontić Ana Pavlović Jelena Kezić Aleksandra Radovanović Jovana Radović Milan |
| author_facet | Karadžić-Ristanović Vidna Gajić Selena Bontić Ana Pavlović Jelena Kezić Aleksandra Radovanović Jovana Radović Milan |
| author_sort | Karadžić-Ristanović Vidna |
| collection | DOAJ |
| description | Background/Aim. Chronic kidney disease (CKD) is a global health concern associated with increased cardio-vascular risks and premature mortality. Proteinuria is a key prognostic indicator for CKD outcome. Sodium-glucose cotransporter 2 (SGLT2) inhibitors show potential for reducing proteinuria and slowing CKD progression. The aim of the study was to determine the impact of SGLT2 inhibitor therapy on CKD patients by evaluating the changes in the level of serum creatinine (sCr), 24-hour (24h) urine protein (UP), estimated glomerular filtration rate (GFR), and blood pressure (BP). Methods. This prospective study monitored 79 patients with CKD on therapy with SGLT2 inhibitors, who were followed up for one year. Patients received an SGLT2 inhibitor (dapagliflozin) once daily (10 mg), and assessment of specific parameters was conducted at baseline, 6 months, and 1 year later during the therapy. The study evaluated the levels of sCr, 24h UP, GFR, systolic BP (BPs), diastolic BP (BPd), uric acid (UA), total cholesterol (TC), triglycerides (Tg), low-density lipoprotein (LDL) cholesterol, sodium (Na+), and potassium (K+). Results. Over the one-year follow-up, significant changes were seen in UA levels (5.36, 4.99, 4.94 mg/dL, respectively; p = 0.032), 24h UP (662.60, 574.11, 417.09 mg/dL, respectively; p = 0.028), as well as BPs (128.44, 125.64, 126.12 mmHg, respectively; p = 0.026). No significant variations were observed in GFR, BPd, sCr, TC, Tg, LDL, and K+ levels. Na+ levels displayed a notable decrease (148.21, 147.57, 146.41 mmol/L, respectively; p = 0.021). Conclusion. The study suggests a potential benefit of SGLT2 inhibitors in managing CKD. |
| first_indexed | 2024-04-24T11:30:23Z |
| format | Article |
| id | doaj.art-e5ca68a41f304fd180c41c1db9d73074 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-04-24T11:30:23Z |
| publishDate | 2024-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-e5ca68a41f304fd180c41c1db9d730742024-04-10T10:28:43ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202024-01-01811394410.2298/VSP230805061K0042-84502300061KEvaluating the renoprotective effectiveness of sodium-glucose co-transporter 2 inhibitor therapy in patients with chronic kidney disease: A prospective studyKaradžić-Ristanović Vidna0Gajić Selena1https://orcid.org/0000-0002-9359-261XBontić Ana2https://orcid.org/0000-0002-8209-8552Pavlović Jelena3https://orcid.org/0009-0002-4249-9551Kezić Aleksandra4Radovanović Jovana5Radović Milan6University Clinical Center of Serbia, Clinic for Nephrology, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic for Nephrology, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic for Nephrology, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic for Nephrology, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Center of Serbia, Clinic for Nephrology, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Kragujevac, SerbiaUniversity Clinical Center of Serbia, Clinic for Nephrology, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaBackground/Aim. Chronic kidney disease (CKD) is a global health concern associated with increased cardio-vascular risks and premature mortality. Proteinuria is a key prognostic indicator for CKD outcome. Sodium-glucose cotransporter 2 (SGLT2) inhibitors show potential for reducing proteinuria and slowing CKD progression. The aim of the study was to determine the impact of SGLT2 inhibitor therapy on CKD patients by evaluating the changes in the level of serum creatinine (sCr), 24-hour (24h) urine protein (UP), estimated glomerular filtration rate (GFR), and blood pressure (BP). Methods. This prospective study monitored 79 patients with CKD on therapy with SGLT2 inhibitors, who were followed up for one year. Patients received an SGLT2 inhibitor (dapagliflozin) once daily (10 mg), and assessment of specific parameters was conducted at baseline, 6 months, and 1 year later during the therapy. The study evaluated the levels of sCr, 24h UP, GFR, systolic BP (BPs), diastolic BP (BPd), uric acid (UA), total cholesterol (TC), triglycerides (Tg), low-density lipoprotein (LDL) cholesterol, sodium (Na+), and potassium (K+). Results. Over the one-year follow-up, significant changes were seen in UA levels (5.36, 4.99, 4.94 mg/dL, respectively; p = 0.032), 24h UP (662.60, 574.11, 417.09 mg/dL, respectively; p = 0.028), as well as BPs (128.44, 125.64, 126.12 mmHg, respectively; p = 0.026). No significant variations were observed in GFR, BPd, sCr, TC, Tg, LDL, and K+ levels. Na+ levels displayed a notable decrease (148.21, 147.57, 146.41 mmol/L, respectively; p = 0.021). Conclusion. The study suggests a potential benefit of SGLT2 inhibitors in managing CKD.https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502300061K.pdfdrug therapyproteinuriarenal insufficiency, chronicsodium-glucose transporter 2 inhibitorstreatment outcome |
| spellingShingle | Karadžić-Ristanović Vidna Gajić Selena Bontić Ana Pavlović Jelena Kezić Aleksandra Radovanović Jovana Radović Milan Evaluating the renoprotective effectiveness of sodium-glucose co-transporter 2 inhibitor therapy in patients with chronic kidney disease: A prospective study Vojnosanitetski Pregled drug therapy proteinuria renal insufficiency, chronic sodium-glucose transporter 2 inhibitors treatment outcome |
| title | Evaluating the renoprotective effectiveness of sodium-glucose co-transporter 2 inhibitor therapy in patients with chronic kidney disease: A prospective study |
| title_full | Evaluating the renoprotective effectiveness of sodium-glucose co-transporter 2 inhibitor therapy in patients with chronic kidney disease: A prospective study |
| title_fullStr | Evaluating the renoprotective effectiveness of sodium-glucose co-transporter 2 inhibitor therapy in patients with chronic kidney disease: A prospective study |
| title_full_unstemmed | Evaluating the renoprotective effectiveness of sodium-glucose co-transporter 2 inhibitor therapy in patients with chronic kidney disease: A prospective study |
| title_short | Evaluating the renoprotective effectiveness of sodium-glucose co-transporter 2 inhibitor therapy in patients with chronic kidney disease: A prospective study |
| title_sort | evaluating the renoprotective effectiveness of sodium glucose co transporter 2 inhibitor therapy in patients with chronic kidney disease a prospective study |
| topic | drug therapy proteinuria renal insufficiency, chronic sodium-glucose transporter 2 inhibitors treatment outcome |
| url | https://doiserbia.nb.rs/img/doi/0042-8450/2024/0042-84502300061K.pdf |
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