The Relationship Between Serum Folate Level and Residual Renal Function in CAPD Patients
Jianpeng Yu,1,* Qi Zhou,1,* Ying Xu,1,* Tieyun Wang,1 Jun Du,1 Lifang Zhao,1 Juan Li,1 Haiyan Wang,1 Qianqian Xu,2 Xueli Lai,1 Zhiyong Guo1 1Department of Nephrology, Shanghai Changhai Hospital, Shanghai, People’s Republic of China; 2Department of Rheumatology and Immunology,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-09-01
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| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-relationship-between-serum-folate-level-and-residual-renal-functio-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1798037413965070336 |
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| author | Yu J Zhou Q Xu Y Wang T Du J Zhao L Li J Wang H Xu Q Lai X Guo Z |
| author_facet | Yu J Zhou Q Xu Y Wang T Du J Zhao L Li J Wang H Xu Q Lai X Guo Z |
| author_sort | Yu J |
| collection | DOAJ |
| description | Jianpeng Yu,1,* Qi Zhou,1,* Ying Xu,1,* Tieyun Wang,1 Jun Du,1 Lifang Zhao,1 Juan Li,1 Haiyan Wang,1 Qianqian Xu,2 Xueli Lai,1 Zhiyong Guo1 1Department of Nephrology, Shanghai Changhai Hospital, Shanghai, People’s Republic of China; 2Department of Rheumatology and Immunology, Shanghai Changhai Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xueli Lai; Zhiyong Guo, Email laixueli_changhai@163.com; drguozhiyong@163.comObjective: To investigate the relationship between serum folate (FA) levels and residual renal function (RRF) in continuous ambulatory peritoneal dialysis (CAPD) patients.Methods: Clinical data were collected from 180 hospitalized patients who received CAPD regularly. Patients were divided into the FA deficiency group and the FA non-deficiency group according to serum FA level. Data on age, sex, PD vintage, hemoglobin, mean corpuscular volume, serum FA, total Kt/V, residual kidney Kt/V, peritoneum Kt/V, creatinine clearance (Ccr), ultrafiltration volume, cystatin C (cytC), serum creatinine (Scr), urea nitrogen, retinol-binding protein and the primary disease were gathered from 2 groups. Statistical methods were used to analyze the relationship between serum FA level and RRF.Results: Peritoneal Kt/V, cytC, Scr were higher, and residual kidney Kt/V was lower in FA deficiency group than in non-deficiency group. Univariate correlation showed the peritoneal Kt/V, cytC, Scr negatively correlated with serum FA while residual kidney Kt/V positively correlated with serum FA, and there was a simple linear regression relationship between serum FA and residual kidney Kt/V. Differences were statistically significant (P< 0.05).Conclusion: There is a relationship between serum FA and RRF in CAPD patients. Prospective studies or trials should be performed to clarify the importance of FA supplementation on RRF during peritoneal dialysis.Keywords: folate, continuous ambulatory peritoneal dialysis, residual renal function |
| first_indexed | 2024-04-11T21:26:15Z |
| format | Article |
| id | doaj.art-e5cb48c65b044f13a3974eee93538d0b |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-11T21:26:15Z |
| publishDate | 2022-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-e5cb48c65b044f13a3974eee93538d0b2022-12-22T04:02:24ZengDove Medical PressInternational Journal of General Medicine1178-70742022-09-01Volume 156977698477921The Relationship Between Serum Folate Level and Residual Renal Function in CAPD PatientsYu JZhou QXu YWang TDu JZhao LLi JWang HXu QLai XGuo ZJianpeng Yu,1,* Qi Zhou,1,* Ying Xu,1,* Tieyun Wang,1 Jun Du,1 Lifang Zhao,1 Juan Li,1 Haiyan Wang,1 Qianqian Xu,2 Xueli Lai,1 Zhiyong Guo1 1Department of Nephrology, Shanghai Changhai Hospital, Shanghai, People’s Republic of China; 2Department of Rheumatology and Immunology, Shanghai Changhai Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xueli Lai; Zhiyong Guo, Email laixueli_changhai@163.com; drguozhiyong@163.comObjective: To investigate the relationship between serum folate (FA) levels and residual renal function (RRF) in continuous ambulatory peritoneal dialysis (CAPD) patients.Methods: Clinical data were collected from 180 hospitalized patients who received CAPD regularly. Patients were divided into the FA deficiency group and the FA non-deficiency group according to serum FA level. Data on age, sex, PD vintage, hemoglobin, mean corpuscular volume, serum FA, total Kt/V, residual kidney Kt/V, peritoneum Kt/V, creatinine clearance (Ccr), ultrafiltration volume, cystatin C (cytC), serum creatinine (Scr), urea nitrogen, retinol-binding protein and the primary disease were gathered from 2 groups. Statistical methods were used to analyze the relationship between serum FA level and RRF.Results: Peritoneal Kt/V, cytC, Scr were higher, and residual kidney Kt/V was lower in FA deficiency group than in non-deficiency group. Univariate correlation showed the peritoneal Kt/V, cytC, Scr negatively correlated with serum FA while residual kidney Kt/V positively correlated with serum FA, and there was a simple linear regression relationship between serum FA and residual kidney Kt/V. Differences were statistically significant (P< 0.05).Conclusion: There is a relationship between serum FA and RRF in CAPD patients. Prospective studies or trials should be performed to clarify the importance of FA supplementation on RRF during peritoneal dialysis.Keywords: folate, continuous ambulatory peritoneal dialysis, residual renal functionhttps://www.dovepress.com/the-relationship-between-serum-folate-level-and-residual-renal-functio-peer-reviewed-fulltext-article-IJGMfolatecontinuous ambulatory peritoneal dialysisresidual renal function |
| spellingShingle | Yu J Zhou Q Xu Y Wang T Du J Zhao L Li J Wang H Xu Q Lai X Guo Z The Relationship Between Serum Folate Level and Residual Renal Function in CAPD Patients International Journal of General Medicine folate continuous ambulatory peritoneal dialysis residual renal function |
| title | The Relationship Between Serum Folate Level and Residual Renal Function in CAPD Patients |
| title_full | The Relationship Between Serum Folate Level and Residual Renal Function in CAPD Patients |
| title_fullStr | The Relationship Between Serum Folate Level and Residual Renal Function in CAPD Patients |
| title_full_unstemmed | The Relationship Between Serum Folate Level and Residual Renal Function in CAPD Patients |
| title_short | The Relationship Between Serum Folate Level and Residual Renal Function in CAPD Patients |
| title_sort | relationship between serum folate level and residual renal function in capd patients |
| topic | folate continuous ambulatory peritoneal dialysis residual renal function |
| url | https://www.dovepress.com/the-relationship-between-serum-folate-level-and-residual-renal-functio-peer-reviewed-fulltext-article-IJGM |
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