Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review
Objective: To review the current findings of the literature on the existence of several profiles of laryngopharyngeal reflux (LPR) patients and to propose personalized diagnostic and therapeutic approaches. Methods: A state-of-the art review of the literature was conducted using the PubMED, Scopus,...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/13/11/1567 |
| _version_ | 1797458746227556352 |
|---|---|
| author | Jerome R. Lechien |
| author_facet | Jerome R. Lechien |
| author_sort | Jerome R. Lechien |
| collection | DOAJ |
| description | Objective: To review the current findings of the literature on the existence of several profiles of laryngopharyngeal reflux (LPR) patients and to propose personalized diagnostic and therapeutic approaches. Methods: A state-of-the art review of the literature was conducted using the PubMED, Scopus, and Cochrane Library databases. The information related to epidemiology, demographics, clinical presentations, diagnostic approaches, and therapeutic responses were extracted to identify outcomes that may influence the clinical and therapeutic courses of LPR. Results: The clinical presentation and therapeutic courses of LPR may be influenced by gender, age, weight, comorbidities, dietary habits and culture, anxiety, stress, and saliva enzyme profile. The clinical expression of reflux, including laryngopharyngeal, respiratory, nasal, and eye symptoms, and the hypopharyngeal–esophageal multichannel intraluminal impedance-pH monitoring profile of patients are important issues to improve in patient management. The use of more personalized therapeutic strategies appears to be associated with better symptom relief and cures over the long-term. The role of pepsin in LPR physiology is well-established but the lack of information about the role of other gastrointestinal enzymes in the development of LPR-related mucosa inflammation limits the development of future enzyme-based personalized diagnostic and therapeutic approaches. Conclusion: Laryngopharyngeal reflux is a challenging ear, nose, and throat condition associated with poor therapeutic responses and a long-term burden in Western countries. Artificial intelligence should be used for developing personalized therapeutic strategies based on patient features. |
| first_indexed | 2024-03-09T16:41:35Z |
| format | Article |
| id | doaj.art-e5cbfde3e4094d5fbe4ed60d0ad79f72 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T16:41:35Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-e5cbfde3e4094d5fbe4ed60d0ad79f722023-11-24T14:51:27ZengMDPI AGJournal of Personalized Medicine2075-44262023-10-011311156710.3390/jpm13111567Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative ReviewJerome R. Lechien0Division of Laryngology and Broncho-Esophagology, Department of Otolaryngology-Head Neck Surgery, EpiCURA Hospital, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), B7000 Baudour, BelgiumObjective: To review the current findings of the literature on the existence of several profiles of laryngopharyngeal reflux (LPR) patients and to propose personalized diagnostic and therapeutic approaches. Methods: A state-of-the art review of the literature was conducted using the PubMED, Scopus, and Cochrane Library databases. The information related to epidemiology, demographics, clinical presentations, diagnostic approaches, and therapeutic responses were extracted to identify outcomes that may influence the clinical and therapeutic courses of LPR. Results: The clinical presentation and therapeutic courses of LPR may be influenced by gender, age, weight, comorbidities, dietary habits and culture, anxiety, stress, and saliva enzyme profile. The clinical expression of reflux, including laryngopharyngeal, respiratory, nasal, and eye symptoms, and the hypopharyngeal–esophageal multichannel intraluminal impedance-pH monitoring profile of patients are important issues to improve in patient management. The use of more personalized therapeutic strategies appears to be associated with better symptom relief and cures over the long-term. The role of pepsin in LPR physiology is well-established but the lack of information about the role of other gastrointestinal enzymes in the development of LPR-related mucosa inflammation limits the development of future enzyme-based personalized diagnostic and therapeutic approaches. Conclusion: Laryngopharyngeal reflux is a challenging ear, nose, and throat condition associated with poor therapeutic responses and a long-term burden in Western countries. Artificial intelligence should be used for developing personalized therapeutic strategies based on patient features.https://www.mdpi.com/2075-4426/13/11/1567laryngopharyngealgastroesophagealrefluxotolaryngologyhead neck surgeryvoice |
| spellingShingle | Jerome R. Lechien Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review Journal of Personalized Medicine laryngopharyngeal gastroesophageal reflux otolaryngology head neck surgery voice |
| title | Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review |
| title_full | Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review |
| title_fullStr | Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review |
| title_full_unstemmed | Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review |
| title_short | Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review |
| title_sort | personalized treatments based on laryngopharyngeal reflux patient profiles a narrative review |
| topic | laryngopharyngeal gastroesophageal reflux otolaryngology head neck surgery voice |
| url | https://www.mdpi.com/2075-4426/13/11/1567 |
| work_keys_str_mv | AT jeromerlechien personalizedtreatmentsbasedonlaryngopharyngealrefluxpatientprofilesanarrativereview |