RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in <it>Salmonella enterica </it>serovar Typhimurium
<p>Abstract</p> <p>Background</p> <p>The survival of <it>Salmonella enterica </it>within the intracellular host niche requires highly co-ordinated expression of virulence effectors predominantly regulated by the SsrAB two-component regulatory system. <it&...
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| Format: | Article |
| Language: | English |
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BMC
2009-02-01
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| Series: | BMC Microbiology |
| Online Access: | http://www.biomedcentral.com/1471-2180/9/45 |
| _version_ | 1818835780808736768 |
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| author | Coombes Brian K Osborne Suzanne E |
| author_facet | Coombes Brian K Osborne Suzanne E |
| author_sort | Coombes Brian K |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The survival of <it>Salmonella enterica </it>within the intracellular host niche requires highly co-ordinated expression of virulence effectors predominantly regulated by the SsrAB two-component regulatory system. <it>S. enterica </it>serovar Typhimurium mutants lacking the <it>ssrAB </it>genes are avirulent in mice, highlighting the importance of this regulatory system <it>in vivo</it>. Mutants lacking the gene encoding the alternative sigma factor σ<sup>E </sup>(<it>rpoE</it>) are also highly attenuated for intracellular survival, pointing to a potential connection with the SsrAB regulatory system.</p> <p>Results</p> <p>In this study we demonstrate that RpoE is involved in fine-tuning the expression of a subset of SsrB-regulated genes found in the <it>Salmonella </it>pathogenicity island-2 (SPI-2) genetic locus that encodes a horizontally acquired type III secretion system, and unlinked genes integrated into this regulon that are required for virulence in host animals.</p> <p>Conclusion</p> <p>These data point to a potential connection between the virulence phenotype of strains lacking <it>ssrB </it>and <it>rpoE</it>, and highlight new transcriptional regulation that might be essential for appropriate temporal and spatial control of the virulence-associated type III secretion system during host infection.</p> |
| first_indexed | 2024-12-19T02:56:09Z |
| format | Article |
| id | doaj.art-e5cf142f1ff84228a60027776f9a9df8 |
| institution | Directory Open Access Journal |
| issn | 1471-2180 |
| language | English |
| last_indexed | 2024-12-19T02:56:09Z |
| publishDate | 2009-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Microbiology |
| spelling | doaj.art-e5cf142f1ff84228a60027776f9a9df82022-12-21T20:38:20ZengBMCBMC Microbiology1471-21802009-02-01914510.1186/1471-2180-9-45RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in <it>Salmonella enterica </it>serovar TyphimuriumCoombes Brian KOsborne Suzanne E<p>Abstract</p> <p>Background</p> <p>The survival of <it>Salmonella enterica </it>within the intracellular host niche requires highly co-ordinated expression of virulence effectors predominantly regulated by the SsrAB two-component regulatory system. <it>S. enterica </it>serovar Typhimurium mutants lacking the <it>ssrAB </it>genes are avirulent in mice, highlighting the importance of this regulatory system <it>in vivo</it>. Mutants lacking the gene encoding the alternative sigma factor σ<sup>E </sup>(<it>rpoE</it>) are also highly attenuated for intracellular survival, pointing to a potential connection with the SsrAB regulatory system.</p> <p>Results</p> <p>In this study we demonstrate that RpoE is involved in fine-tuning the expression of a subset of SsrB-regulated genes found in the <it>Salmonella </it>pathogenicity island-2 (SPI-2) genetic locus that encodes a horizontally acquired type III secretion system, and unlinked genes integrated into this regulon that are required for virulence in host animals.</p> <p>Conclusion</p> <p>These data point to a potential connection between the virulence phenotype of strains lacking <it>ssrB </it>and <it>rpoE</it>, and highlight new transcriptional regulation that might be essential for appropriate temporal and spatial control of the virulence-associated type III secretion system during host infection.</p>http://www.biomedcentral.com/1471-2180/9/45 |
| spellingShingle | Coombes Brian K Osborne Suzanne E RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in <it>Salmonella enterica </it>serovar Typhimurium BMC Microbiology |
| title | RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in <it>Salmonella enterica </it>serovar Typhimurium |
| title_full | RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in <it>Salmonella enterica </it>serovar Typhimurium |
| title_fullStr | RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in <it>Salmonella enterica </it>serovar Typhimurium |
| title_full_unstemmed | RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in <it>Salmonella enterica </it>serovar Typhimurium |
| title_short | RpoE fine tunes expression of a subset of SsrB-regulated virulence factors in <it>Salmonella enterica </it>serovar Typhimurium |
| title_sort | rpoe fine tunes expression of a subset of ssrb regulated virulence factors in it salmonella enterica it serovar typhimurium |
| url | http://www.biomedcentral.com/1471-2180/9/45 |
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