Fronto-striato network function is reduced in major depressive disorder
IntroductionMajor depressive disorder (MDD) is a major cause of poor quality of life and disability and is highly prevalent worldwide. Various pathological mechanisms are implicated in MDD, including the reward system. The human brain is equipped with a reward system that is involved in aspects such...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-03-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1336370/full |
| _version_ | 1797272587150032896 |
|---|---|
| author | Reoto Kijima Keita Watanabe Naomichi Okamoto Atsuko Ikenouchi Hirofumi Tesen Shingo Kakeda Reiji Yoshimura |
| author_facet | Reoto Kijima Keita Watanabe Naomichi Okamoto Atsuko Ikenouchi Hirofumi Tesen Shingo Kakeda Reiji Yoshimura |
| author_sort | Reoto Kijima |
| collection | DOAJ |
| description | IntroductionMajor depressive disorder (MDD) is a major cause of poor quality of life and disability and is highly prevalent worldwide. Various pathological mechanisms are implicated in MDD, including the reward system. The human brain is equipped with a reward system that is involved in aspects such as motivation, pleasure, and learning. Several studies including a meta-analysis have been reported on the reward system network and MDD. However, to our knowledge, no studies have examined the relationship between the reward system network of drug-naïve, first-episode MDD patients and the detailed symptoms of MDD or age. The fronto-striato network (FSN) is closely related to the reward system network. The present study primarily aimed to elucidate this point.MethodsA total of 89 drug-naïve first-episode MDD patients and 82 healthy controls (HCs) patients were enrolled in the study. The correlation between the FSN and age and the interaction between age and illness in the FSN were investigated in 75 patients in the MDD group and 79 patients in the HC group with available information on the FSN and age. In addition, the association between the FSN and the total scores on the 17-item Hamilton Rating Scale for Depression (HAMD-17) and scores in each symptom item was analyzed in 76 MDD subjects with information on the FSN and HAMD-17. The significance of each result was evaluated according to a p-value of <0.05.ResultsAge was inversely correlated with the FSN (p=2.14e-11) in the HC group but not in the MDD group (p=0.79). FSN varied with the presence of MDD and with age, particularly showing an interaction with MDD and age (p=1.04e-08). Specifically, age and the presence or absence of MDD each affected FSN, but the effect of age on FSN changed in the presence of depression. FSN did not correlate with total HAMD-17 scores or scores in each item.DiscussionThe reward system may be dysfunctional in patients with MDD. In addition, the effect could be greater in younger patients. Meanwhile, there is no correlation between the function of the reward system and the severity of MDD or the severity of each symptom. Thus, the reward system network may be an important biological marker of MDD, although careful consideration should be given to age and its association with the severity of the disorder.ConclusionThe reward system function is decreased in MDD patients, and this decrease may be more pronounced in younger patients, although further research is still needed. |
| first_indexed | 2024-03-07T14:31:29Z |
| format | Article |
| id | doaj.art-e5d11f44a30a42c4a890914d99ef4232 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-07T14:31:29Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-e5d11f44a30a42c4a890914d99ef42322024-03-06T04:41:46ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-03-011510.3389/fpsyt.2024.13363701336370Fronto-striato network function is reduced in major depressive disorderReoto Kijima0Keita Watanabe1Naomichi Okamoto2Atsuko Ikenouchi3Hirofumi Tesen4Shingo Kakeda5Reiji Yoshimura6Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, JapanDepartment of Radiology, Kyoto Prefectural University of Medicine, Kyoto, JapanDepartment of Psychiatry, University of Occupational and Environmental Health, Fukuoka, JapanDepartment of Psychiatry, University of Occupational and Environmental Health, Fukuoka, JapanDepartment of Psychiatry, University of Occupational and Environmental Health, Fukuoka, JapanDepartment of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki, JapanDepartment of Psychiatry, University of Occupational and Environmental Health, Fukuoka, JapanIntroductionMajor depressive disorder (MDD) is a major cause of poor quality of life and disability and is highly prevalent worldwide. Various pathological mechanisms are implicated in MDD, including the reward system. The human brain is equipped with a reward system that is involved in aspects such as motivation, pleasure, and learning. Several studies including a meta-analysis have been reported on the reward system network and MDD. However, to our knowledge, no studies have examined the relationship between the reward system network of drug-naïve, first-episode MDD patients and the detailed symptoms of MDD or age. The fronto-striato network (FSN) is closely related to the reward system network. The present study primarily aimed to elucidate this point.MethodsA total of 89 drug-naïve first-episode MDD patients and 82 healthy controls (HCs) patients were enrolled in the study. The correlation between the FSN and age and the interaction between age and illness in the FSN were investigated in 75 patients in the MDD group and 79 patients in the HC group with available information on the FSN and age. In addition, the association between the FSN and the total scores on the 17-item Hamilton Rating Scale for Depression (HAMD-17) and scores in each symptom item was analyzed in 76 MDD subjects with information on the FSN and HAMD-17. The significance of each result was evaluated according to a p-value of <0.05.ResultsAge was inversely correlated with the FSN (p=2.14e-11) in the HC group but not in the MDD group (p=0.79). FSN varied with the presence of MDD and with age, particularly showing an interaction with MDD and age (p=1.04e-08). Specifically, age and the presence or absence of MDD each affected FSN, but the effect of age on FSN changed in the presence of depression. FSN did not correlate with total HAMD-17 scores or scores in each item.DiscussionThe reward system may be dysfunctional in patients with MDD. In addition, the effect could be greater in younger patients. Meanwhile, there is no correlation between the function of the reward system and the severity of MDD or the severity of each symptom. Thus, the reward system network may be an important biological marker of MDD, although careful consideration should be given to age and its association with the severity of the disorder.ConclusionThe reward system function is decreased in MDD patients, and this decrease may be more pronounced in younger patients, although further research is still needed.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1336370/fullmajor depressionreward systemstriatumprefrontal cortexfirst episode |
| spellingShingle | Reoto Kijima Keita Watanabe Naomichi Okamoto Atsuko Ikenouchi Hirofumi Tesen Shingo Kakeda Reiji Yoshimura Fronto-striato network function is reduced in major depressive disorder Frontiers in Psychiatry major depression reward system striatum prefrontal cortex first episode |
| title | Fronto-striato network function is reduced in major depressive disorder |
| title_full | Fronto-striato network function is reduced in major depressive disorder |
| title_fullStr | Fronto-striato network function is reduced in major depressive disorder |
| title_full_unstemmed | Fronto-striato network function is reduced in major depressive disorder |
| title_short | Fronto-striato network function is reduced in major depressive disorder |
| title_sort | fronto striato network function is reduced in major depressive disorder |
| topic | major depression reward system striatum prefrontal cortex first episode |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1336370/full |
| work_keys_str_mv | AT reotokijima frontostriatonetworkfunctionisreducedinmajordepressivedisorder AT keitawatanabe frontostriatonetworkfunctionisreducedinmajordepressivedisorder AT naomichiokamoto frontostriatonetworkfunctionisreducedinmajordepressivedisorder AT atsukoikenouchi frontostriatonetworkfunctionisreducedinmajordepressivedisorder AT hirofumitesen frontostriatonetworkfunctionisreducedinmajordepressivedisorder AT shingokakeda frontostriatonetworkfunctionisreducedinmajordepressivedisorder AT reijiyoshimura frontostriatonetworkfunctionisreducedinmajordepressivedisorder |