3-Substituted Prolines: From Synthesis to Structural Applications, from Peptides to Foldamers

3-Substituted Prolines: From Synthesis to Structural Applications, from Peptides to Foldamers

Among the twenty natural proteinogenic amino acids, proline is unique as its secondary amine forms a tertiary amide when incorporated into biopolymers, thus preventing hydrogen bond formation. Despite the lack of hydrogen bonds and thanks to conformational restriction of flexibility linked to the py...

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Bibliographic Details
Main Authors: Benoit Oswald, Olivier Lequin, Philippe Karoyan, Roba Moumné, Nicolas Delsuc, Sylvain Darses, Alexandre Guez, Thomas Gendrineau, Héloïse Boullet, Cécile Caumes, Céline Mothes
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Molecules
Subjects:
substituted proline
peptide
peptidomimetics
b-turn
PPII helix
Online Access:http://www.mdpi.com/1420-3049/18/2/2307

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