Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head
Abstract Background Alcohol‐induced osteonecrosis of femoral head (ONFH) is a complex disease and genetic factors are one of the causes. The purpose of this study is to investigate the effects of RETN (resistin; OMIM: 605565) and LDLR (low density lipoprotein receptor; OMIM: 606945) polymorphisms on...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-08-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.822 |
| _version_ | 1797988239258157056 |
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| author | Chang Liu Feimeng An Yuju Cao Jiaqi Wang Ye Tian Huiqiang Wu Jianzhong Wang |
| author_facet | Chang Liu Feimeng An Yuju Cao Jiaqi Wang Ye Tian Huiqiang Wu Jianzhong Wang |
| author_sort | Chang Liu |
| collection | DOAJ |
| description | Abstract Background Alcohol‐induced osteonecrosis of femoral head (ONFH) is a complex disease and genetic factors are one of the causes. The purpose of this study is to investigate the effects of RETN (resistin; OMIM: 605565) and LDLR (low density lipoprotein receptor; OMIM: 606945) polymorphisms on the risk of alcohol‐induced ONFH in Chinese Han population. Methods A case–control study including 201 patients and 201 controls was designed. Seven single nucleotide polymorphisms (SNPs) in RETN gene and four SNPs in LDLR gene were genotyped using Agena MassARRAY platform. In allele model and genetic model, chi‐square test and logistic regression were used to study the associations between these SNPs and ONFH susceptibility. In addition, the relationships between these SNPs, clinical phenotypes, and blood lipid level with one‐way analysis of variance were analyzed. Results In the allele model, rs7408174 and rs3745369 in RETN were associated with increased risk of alcohol‐induced ONFH, whereas rs34861192 and rs3219175 in RETN showed reduced risk of alcohol‐induced ONFH. In the genetic model, rs7408174 was associated with increased risk of alcohol‐induced ONFH in dominant model and log‐additive model. Rs3745369 showed an increased risk in codominant model, recessive model, and log‐additive model. Rs34861192 showed a decreased risk in codominant model, dominant model, and log‐additive model, and rs3219175 showed a decreased risk in dominant model and log‐additive model. The rs3745368 in RETN was associated with the clinical stage of the disease. Conclusion These results suggest that RETN genetic polymorphisms are associated with the susceptibility of alcohol‐induced ONFH in Chinese Han population. |
| first_indexed | 2024-04-11T07:59:39Z |
| format | Article |
| id | doaj.art-e5d60a326a86470ab75d0881418bff1a |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-04-11T07:59:39Z |
| publishDate | 2019-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-e5d60a326a86470ab75d0881418bff1a2022-12-22T04:35:45ZengWileyMolecular Genetics & Genomic Medicine2324-92692019-08-0178n/an/a10.1002/mgg3.822Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral headChang Liu0Feimeng An1Yuju Cao2Jiaqi Wang3Ye Tian4Huiqiang Wu5Jianzhong Wang6Inner Mongolia Medical University Hohhot ChinaInner Mongolia Medical University Hohhot ChinaZhengzhou Traditional Chinese Medicine (TCM) Traumatology Hospital Zhengzhou ChinaInner Mongolia Medical University Hohhot ChinaInner Mongolia Medical University Hohhot ChinaInner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine Hohhot ChinaDepartment of Orthopedics and Traumatology The Second Affiliated Hospital of Inner Mongolia Medical University Hohhot ChinaAbstract Background Alcohol‐induced osteonecrosis of femoral head (ONFH) is a complex disease and genetic factors are one of the causes. The purpose of this study is to investigate the effects of RETN (resistin; OMIM: 605565) and LDLR (low density lipoprotein receptor; OMIM: 606945) polymorphisms on the risk of alcohol‐induced ONFH in Chinese Han population. Methods A case–control study including 201 patients and 201 controls was designed. Seven single nucleotide polymorphisms (SNPs) in RETN gene and four SNPs in LDLR gene were genotyped using Agena MassARRAY platform. In allele model and genetic model, chi‐square test and logistic regression were used to study the associations between these SNPs and ONFH susceptibility. In addition, the relationships between these SNPs, clinical phenotypes, and blood lipid level with one‐way analysis of variance were analyzed. Results In the allele model, rs7408174 and rs3745369 in RETN were associated with increased risk of alcohol‐induced ONFH, whereas rs34861192 and rs3219175 in RETN showed reduced risk of alcohol‐induced ONFH. In the genetic model, rs7408174 was associated with increased risk of alcohol‐induced ONFH in dominant model and log‐additive model. Rs3745369 showed an increased risk in codominant model, recessive model, and log‐additive model. Rs34861192 showed a decreased risk in codominant model, dominant model, and log‐additive model, and rs3219175 showed a decreased risk in dominant model and log‐additive model. The rs3745368 in RETN was associated with the clinical stage of the disease. Conclusion These results suggest that RETN genetic polymorphisms are associated with the susceptibility of alcohol‐induced ONFH in Chinese Han population.https://doi.org/10.1002/mgg3.822alcohol‐induced osteonecrosis of femoral headLDLRRETNsingle nucleotide polymorphisms |
| spellingShingle | Chang Liu Feimeng An Yuju Cao Jiaqi Wang Ye Tian Huiqiang Wu Jianzhong Wang Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head Molecular Genetics & Genomic Medicine alcohol‐induced osteonecrosis of femoral head LDLR RETN single nucleotide polymorphisms |
| title | Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head |
| title_full | Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head |
| title_fullStr | Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head |
| title_full_unstemmed | Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head |
| title_short | Significant association between RETN genetic polymorphisms and alcohol‐induced osteonecrosis of femoral head |
| title_sort | significant association between retn genetic polymorphisms and alcohol induced osteonecrosis of femoral head |
| topic | alcohol‐induced osteonecrosis of femoral head LDLR RETN single nucleotide polymorphisms |
| url | https://doi.org/10.1002/mgg3.822 |
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