Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews
The objective of this study is to evaluate the effectiveness and safety of ozone therapy (OT) in the treatment of knee osteoarthritis (KOA), which is the most common form of the disease. We analysed systematic reviews (SRs) of randomised controlled trials (RCTs) using the “A MeaSurement Tool to Asse...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1348028/full |
| _version_ | 1797302442001432576 |
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| author | Valéria T. S. Lino Daniel S. Marinho Nadia C. P. Rodrigues Nadia C. P. Rodrigues Carlos A. F. Andrade Carlos A. F. Andrade |
| author_facet | Valéria T. S. Lino Daniel S. Marinho Nadia C. P. Rodrigues Nadia C. P. Rodrigues Carlos A. F. Andrade Carlos A. F. Andrade |
| author_sort | Valéria T. S. Lino |
| collection | DOAJ |
| description | The objective of this study is to evaluate the effectiveness and safety of ozone therapy (OT) in the treatment of knee osteoarthritis (KOA), which is the most common form of the disease. We analysed systematic reviews (SRs) of randomised controlled trials (RCTs) using the “A MeaSurement Tool to Assess systematic Reviews” (AMSTAR2) instrument to evaluate their quality. We developed a narrative synthesis report with eight SRs (15 RCTs/3,685 patients) to summarise the findings. The AMSTAR2 analysis indicated that all reviews had critically low confidence ratings. Statistically significant effects in pain reduction using OT compared to placebo groups were reported in three SRs. OT was shown to be comparable to other therapies in one SR and not superior in the other five. Six SRs highlighted the need for additional RCTs with improved methodological quality to confirm the efficacy of OT for KOA. SRs found fewer consistent effects for improving joint function. Regarding safety, seven SRs reported a low prevalence of minor adverse events linked with OT. Finally, this umbrella review highlights the beneficial effects and safety of OT in the treatment of KOA, particularly in pain control. The low methodological quality of RCTs and SRs limits the possibility of drawing conclusions on the effectiveness of the procedure in comparison to other therapies. Ensure adequate compliance with guidelines such as Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and AMSTAR2 has the ability to improve the quality of SRs in this area. |
| first_indexed | 2024-03-07T23:37:54Z |
| format | Article |
| id | doaj.art-e5d662d5a67c4a8d90b125b3364d8378 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-07T23:37:54Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e5d662d5a67c4a8d90b125b3364d83782024-02-20T05:34:38ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-02-011510.3389/fphys.2024.13480281348028Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviewsValéria T. S. Lino0Daniel S. Marinho1Nadia C. P. Rodrigues2Nadia C. P. Rodrigues3Carlos A. F. Andrade4Carlos A. F. Andrade5Primary Care Department- Germano Sinval Faria School Health Center, Sergio Arouca National School of Public Health- Oswaldo Cruz Foundation, Rio de Janeiro, BrazilDepartment of Epidemiology and Quantitative Methods in Health, Sergio Arouca National School of Public Health- Oswaldo Cruz Foundation- Rio de Janeiro, Rio de Janeiro, BrazilPrimary Care Department- Germano Sinval Faria School Health Center, Sergio Arouca National School of Public Health- Oswaldo Cruz Foundation, Rio de Janeiro, BrazilInstitute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, BrazilDepartment of Epidemiology and Quantitative Methods in Health, Sergio Arouca National School of Public Health- Oswaldo Cruz Foundation- Rio de Janeiro, Rio de Janeiro, BrazilFaculty of Medicine, Vassouras University–Vassouras–Rio de Janeiro, Vassouras, BrazilThe objective of this study is to evaluate the effectiveness and safety of ozone therapy (OT) in the treatment of knee osteoarthritis (KOA), which is the most common form of the disease. We analysed systematic reviews (SRs) of randomised controlled trials (RCTs) using the “A MeaSurement Tool to Assess systematic Reviews” (AMSTAR2) instrument to evaluate their quality. We developed a narrative synthesis report with eight SRs (15 RCTs/3,685 patients) to summarise the findings. The AMSTAR2 analysis indicated that all reviews had critically low confidence ratings. Statistically significant effects in pain reduction using OT compared to placebo groups were reported in three SRs. OT was shown to be comparable to other therapies in one SR and not superior in the other five. Six SRs highlighted the need for additional RCTs with improved methodological quality to confirm the efficacy of OT for KOA. SRs found fewer consistent effects for improving joint function. Regarding safety, seven SRs reported a low prevalence of minor adverse events linked with OT. Finally, this umbrella review highlights the beneficial effects and safety of OT in the treatment of KOA, particularly in pain control. The low methodological quality of RCTs and SRs limits the possibility of drawing conclusions on the effectiveness of the procedure in comparison to other therapies. Ensure adequate compliance with guidelines such as Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and AMSTAR2 has the ability to improve the quality of SRs in this area.https://www.frontiersin.org/articles/10.3389/fphys.2024.1348028/fullozone therapyknee osteoarthritisumbrella reviewsystematic reviewAMSTAR2randomized controlled trials |
| spellingShingle | Valéria T. S. Lino Daniel S. Marinho Nadia C. P. Rodrigues Nadia C. P. Rodrigues Carlos A. F. Andrade Carlos A. F. Andrade Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews Frontiers in Physiology ozone therapy knee osteoarthritis umbrella review systematic review AMSTAR2 randomized controlled trials |
| title | Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews |
| title_full | Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews |
| title_fullStr | Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews |
| title_full_unstemmed | Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews |
| title_short | Efficacy and safety of ozone therapy for knee osteoarthritis: an umbrella review of systematic reviews |
| title_sort | efficacy and safety of ozone therapy for knee osteoarthritis an umbrella review of systematic reviews |
| topic | ozone therapy knee osteoarthritis umbrella review systematic review AMSTAR2 randomized controlled trials |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1348028/full |
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