Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein <i>Tiny Tim 2</i> in Drosophila Somatic Epithelia
We have undertaken a study towards understanding the effect of ectopic expression of testis proteins in the soma in Drosophila. Here, we show that in the larval neuroepithelium, ectopic expression of the germline-specific component of the inner mitochondrial translocation complex <i>tiny tim 2...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/8/1842 |
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| author | Cristina Molnar Anxela Louzao Cayetano Gonzalez |
| author_facet | Cristina Molnar Anxela Louzao Cayetano Gonzalez |
| author_sort | Cristina Molnar |
| collection | DOAJ |
| description | We have undertaken a study towards understanding the effect of ectopic expression of testis proteins in the soma in Drosophila. Here, we show that in the larval neuroepithelium, ectopic expression of the germline-specific component of the inner mitochondrial translocation complex <i>tiny tim 2</i> (<i>ttm2</i>) brings about cell autonomous hyperplasia and extension of G2 phase. In the wing discs, cells expressing ectopic <i>ttm2</i> upregulate Jun N-terminal kinase (JNK) signaling, present extended G2, become invasive, and elicit non-cell autonomous G2 extension and overgrowth of the wild-type neighboring tissue. Ectopic <i>tomboy20</i>, a germline-specific member of the outer mitochondrial translocation complex is also tumorigenic in wing discs. Our results demonstrate the tumorigenic potential of unscheduled expression of these two testis proteins in the soma. They also show that a unique tumorigenic event may trigger different tumor growth pathways depending on the tissular context. |
| first_indexed | 2024-03-10T17:54:21Z |
| format | Article |
| id | doaj.art-e5d752e3da404fac9a7d575c4f9025e2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T17:54:21Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e5d752e3da404fac9a7d575c4f9025e22023-11-20T09:15:54ZengMDPI AGCells2073-44092020-08-0198184210.3390/cells9081842Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein <i>Tiny Tim 2</i> in Drosophila Somatic EpitheliaCristina Molnar0Anxela Louzao1Cayetano Gonzalez2Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, SpainInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, SpainInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, SpainWe have undertaken a study towards understanding the effect of ectopic expression of testis proteins in the soma in Drosophila. Here, we show that in the larval neuroepithelium, ectopic expression of the germline-specific component of the inner mitochondrial translocation complex <i>tiny tim 2</i> (<i>ttm2</i>) brings about cell autonomous hyperplasia and extension of G2 phase. In the wing discs, cells expressing ectopic <i>ttm2</i> upregulate Jun N-terminal kinase (JNK) signaling, present extended G2, become invasive, and elicit non-cell autonomous G2 extension and overgrowth of the wild-type neighboring tissue. Ectopic <i>tomboy20</i>, a germline-specific member of the outer mitochondrial translocation complex is also tumorigenic in wing discs. Our results demonstrate the tumorigenic potential of unscheduled expression of these two testis proteins in the soma. They also show that a unique tumorigenic event may trigger different tumor growth pathways depending on the tissular context.https://www.mdpi.com/2073-4409/9/8/1842drosophila cancer modelcancer/testis geneshyperplasia |
| spellingShingle | Cristina Molnar Anxela Louzao Cayetano Gonzalez Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein <i>Tiny Tim 2</i> in Drosophila Somatic Epithelia Cells drosophila cancer model cancer/testis genes hyperplasia |
| title | Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein <i>Tiny Tim 2</i> in Drosophila Somatic Epithelia |
| title_full | Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein <i>Tiny Tim 2</i> in Drosophila Somatic Epithelia |
| title_fullStr | Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein <i>Tiny Tim 2</i> in Drosophila Somatic Epithelia |
| title_full_unstemmed | Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein <i>Tiny Tim 2</i> in Drosophila Somatic Epithelia |
| title_short | Context-Dependent Tumorigenic Effect of Testis-Specific Mitochondrial Protein <i>Tiny Tim 2</i> in Drosophila Somatic Epithelia |
| title_sort | context dependent tumorigenic effect of testis specific mitochondrial protein i tiny tim 2 i in drosophila somatic epithelia |
| topic | drosophila cancer model cancer/testis genes hyperplasia |
| url | https://www.mdpi.com/2073-4409/9/8/1842 |
| work_keys_str_mv | AT cristinamolnar contextdependenttumorigeniceffectoftestisspecificmitochondrialproteinitinytim2iindrosophilasomaticepithelia AT anxelalouzao contextdependenttumorigeniceffectoftestisspecificmitochondrialproteinitinytim2iindrosophilasomaticepithelia AT cayetanogonzalez contextdependenttumorigeniceffectoftestisspecificmitochondrialproteinitinytim2iindrosophilasomaticepithelia |