Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury
Mismatch negativity is generated automatically, and is an early monitoring indicator of neuronal integrity impairment and functional abnormality in patients with brain injury, leading to decline of cognitive function. Antipsychotic medication cannot affect mismatch negativity. The present study aime...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=618;epage=623;aulast=Sun |
| _version_ | 1819019725967982592 |
|---|---|
| author | Hui-yan Sun Qiang Li Xi-ping Chen Lu-yang Tao |
| author_facet | Hui-yan Sun Qiang Li Xi-ping Chen Lu-yang Tao |
| author_sort | Hui-yan Sun |
| collection | DOAJ |
| description | Mismatch negativity is generated automatically, and is an early monitoring indicator of neuronal integrity impairment and functional abnormality in patients with brain injury, leading to decline of cognitive function. Antipsychotic medication cannot affect mismatch negativity. The present study aimed to explore the relationships of mismatch negativity with neurocognition, daily life and social functional outcomes in patients after brain injury. Twelve patients with traumatic brain injury and 12 healthy controls were recruited in this study. We examined neurocognition with the Wechsler Adult Intelligence Scale-Revised China, and daily and social functional outcomes with the Activity of Daily Living Scale and Social Disability Screening Schedule, respectively. Mismatch negativity was analyzed from electroencephalogram recording. The results showed that mismatch negativity amplitudes decreased in patients with traumatic brain injury compared with healthy controls. Mismatch negativity amplitude was negatively correlated with measurements of neurocognition and positively correlated with functional outcomes in patients after traumatic brain injury. Further, the most significant positive correlations were found between mismatch negativity in the fronto-central region and measures of functional outcomes. The most significant positive correlations were also found between mismatch negativity at the FCz electrode and daily living function. Mismatch negativity amplitudes were extremely positively associated with Social Disability Screening Schedule scores at the Fz electrode in brain injury patients. These experimental findings suggest that mismatch negativity might efficiently reflect functional outcomes in patients after traumatic brain injury. |
| first_indexed | 2024-12-21T03:39:53Z |
| format | Article |
| id | doaj.art-e5d8a3bd9842431ea9fef4f8d8b85b96 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-21T03:39:53Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-e5d8a3bd9842431ea9fef4f8d8b85b962022-12-21T19:17:14ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110461862310.4103/1673-5374.155437Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injuryHui-yan SunQiang LiXi-ping ChenLu-yang TaoMismatch negativity is generated automatically, and is an early monitoring indicator of neuronal integrity impairment and functional abnormality in patients with brain injury, leading to decline of cognitive function. Antipsychotic medication cannot affect mismatch negativity. The present study aimed to explore the relationships of mismatch negativity with neurocognition, daily life and social functional outcomes in patients after brain injury. Twelve patients with traumatic brain injury and 12 healthy controls were recruited in this study. We examined neurocognition with the Wechsler Adult Intelligence Scale-Revised China, and daily and social functional outcomes with the Activity of Daily Living Scale and Social Disability Screening Schedule, respectively. Mismatch negativity was analyzed from electroencephalogram recording. The results showed that mismatch negativity amplitudes decreased in patients with traumatic brain injury compared with healthy controls. Mismatch negativity amplitude was negatively correlated with measurements of neurocognition and positively correlated with functional outcomes in patients after traumatic brain injury. Further, the most significant positive correlations were found between mismatch negativity in the fronto-central region and measures of functional outcomes. The most significant positive correlations were also found between mismatch negativity at the FCz electrode and daily living function. Mismatch negativity amplitudes were extremely positively associated with Social Disability Screening Schedule scores at the Fz electrode in brain injury patients. These experimental findings suggest that mismatch negativity might efficiently reflect functional outcomes in patients after traumatic brain injury.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=618;epage=623;aulast=Sunspinal cord injurypropriospinal systemneural plasticityfiber sproutingneural repaircompensationregenerationpropriospinal detoursneurotrophic factorscell-adhesive ligandsdorsal root gangliaL1CAMnerve growth factorbiomaterialselastin-like proteinsAlzheimer′s diseaseAMPKapoptosisautophagycentral nervous systemCCN4EGFdiabetes mellituserythropoietinEPOFGFIGF-1mTORneuronneuropathyoxidative stresspsychiatricstem cellsWISP1Wntperipheral nerve injurynerve graftnerve conduitWallerian degenerationneurotrophic factorsveinsautograftsnerve regenerationnerve regenerationneuroprotectionresveratrolcerebral ischemiacerebral infarctionmatrix metalloproteinasemolecular dockingextracellular matrixneural regenerationnerve regenerationvagus nerve stimulationcerebral ischemiainflammatory cytokinesinfarct volumeneurological functionNSFC grantsneural regenerationnerve regenerationXingnao Kaiqiao needling methodischemic strokerandomized controlled trialsystemic reviewsmeta-analysislong-term efficacymortalityrecurrencedisabilityadverse reactionshealth economics indicatorsneural regenerationnerve regenerationDDPHcerebral ischemiahippocampusblood flowisolated basilar arterydose-response curveNSFC grantneural regenerationnerve regenerationtraumatic brain injurycomamedian nerve electrical stimulationwake-promotingorexin-AOX1RNSFC grantsneural regenerationnerve regenerationseizureantiepileptic drugsimmature brainhippocampussynaptic plasticityglutamate receptorNSFC grantneural regenerationnerve regenerationpuerarinin vitro experimentsco-cultureneuronsastrocytesTranswellneonatal ratsneural regenerationnerve regenerationbrain injuryinflammatory reactioninterleukin-6voltage-gated Na + channelcortical neuronscerebrospinal fluidneuroimmunomodulationneuroprotectionaction potentialpatch clampneurophysiologyNSFC grantsneural regenerationnerve regenerationbrain injurycognition disordersdiagnostic techniquesWechsler Intelligence Scaleevent-related potentialneuronal plasticityelectrophysiologyneuropsychologyactivity of daily livingwork capacity evaluationelectroencephalogramneural regenerationNSFC grant |
| spellingShingle | Hui-yan Sun Qiang Li Xi-ping Chen Lu-yang Tao Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury Neural Regeneration Research spinal cord injury propriospinal system neural plasticity fiber sprouting neural repair compensation regeneration propriospinal detours neurotrophic factors cell-adhesive ligands dorsal root ganglia L1CAM nerve growth factor biomaterials elastin-like proteins Alzheimer′s disease AMPK apoptosis autophagy central nervous system CCN4 EGF diabetes mellitus erythropoietin EPO FGF IGF-1 mTOR neuron neuropathy oxidative stress psychiatric stem cells WISP1 Wnt peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration nerve regeneration neuroprotection resveratrol cerebral ischemia cerebral infarction matrix metalloproteinase molecular docking extracellular matrix neural regeneration nerve regeneration vagus nerve stimulation cerebral ischemia inflammatory cytokines infarct volume neurological function NSFC grants neural regeneration nerve regeneration Xingnao Kaiqiao needling method ischemic stroke randomized controlled trial systemic reviews meta-analysis long-term efficacy mortality recurrence disability adverse reactions health economics indicators neural regeneration nerve regeneration DDPH cerebral ischemia hippocampus blood flow isolated basilar artery dose-response curve NSFC grant neural regeneration nerve regeneration traumatic brain injury coma median nerve electrical stimulation wake-promoting orexin-A OX1R NSFC grants neural regeneration nerve regeneration seizure antiepileptic drugs immature brain hippocampus synaptic plasticity glutamate receptor NSFC grant neural regeneration nerve regeneration puerarin in vitro experiments co-culture neurons astrocytes Transwell neonatal rats neural regeneration nerve regeneration brain injury inflammatory reaction interleukin-6 voltage-gated Na + channel cortical neurons cerebrospinal fluid neuroimmunomodulation neuroprotection action potential patch clamp neurophysiology NSFC grants neural regeneration nerve regeneration brain injury cognition disorders diagnostic techniques Wechsler Intelligence Scale event-related potential neuronal plasticity electrophysiology neuropsychology activity of daily living work capacity evaluation electroencephalogram neural regeneration NSFC grant |
| title | Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury |
| title_full | Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury |
| title_fullStr | Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury |
| title_full_unstemmed | Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury |
| title_short | Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury |
| title_sort | mismatch negativity social cognition and functional outcomes in patients after traumatic brain injury |
| topic | spinal cord injury propriospinal system neural plasticity fiber sprouting neural repair compensation regeneration propriospinal detours neurotrophic factors cell-adhesive ligands dorsal root ganglia L1CAM nerve growth factor biomaterials elastin-like proteins Alzheimer′s disease AMPK apoptosis autophagy central nervous system CCN4 EGF diabetes mellitus erythropoietin EPO FGF IGF-1 mTOR neuron neuropathy oxidative stress psychiatric stem cells WISP1 Wnt peripheral nerve injury nerve graft nerve conduit Wallerian degeneration neurotrophic factors veins autografts nerve regeneration nerve regeneration neuroprotection resveratrol cerebral ischemia cerebral infarction matrix metalloproteinase molecular docking extracellular matrix neural regeneration nerve regeneration vagus nerve stimulation cerebral ischemia inflammatory cytokines infarct volume neurological function NSFC grants neural regeneration nerve regeneration Xingnao Kaiqiao needling method ischemic stroke randomized controlled trial systemic reviews meta-analysis long-term efficacy mortality recurrence disability adverse reactions health economics indicators neural regeneration nerve regeneration DDPH cerebral ischemia hippocampus blood flow isolated basilar artery dose-response curve NSFC grant neural regeneration nerve regeneration traumatic brain injury coma median nerve electrical stimulation wake-promoting orexin-A OX1R NSFC grants neural regeneration nerve regeneration seizure antiepileptic drugs immature brain hippocampus synaptic plasticity glutamate receptor NSFC grant neural regeneration nerve regeneration puerarin in vitro experiments co-culture neurons astrocytes Transwell neonatal rats neural regeneration nerve regeneration brain injury inflammatory reaction interleukin-6 voltage-gated Na + channel cortical neurons cerebrospinal fluid neuroimmunomodulation neuroprotection action potential patch clamp neurophysiology NSFC grants neural regeneration nerve regeneration brain injury cognition disorders diagnostic techniques Wechsler Intelligence Scale event-related potential neuronal plasticity electrophysiology neuropsychology activity of daily living work capacity evaluation electroencephalogram neural regeneration NSFC grant |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=4;spage=618;epage=623;aulast=Sun |
| work_keys_str_mv | AT huiyansun mismatchnegativitysocialcognitionandfunctionaloutcomesinpatientsaftertraumaticbraininjury AT qiangli mismatchnegativitysocialcognitionandfunctionaloutcomesinpatientsaftertraumaticbraininjury AT xipingchen mismatchnegativitysocialcognitionandfunctionaloutcomesinpatientsaftertraumaticbraininjury AT luyangtao mismatchnegativitysocialcognitionandfunctionaloutcomesinpatientsaftertraumaticbraininjury |