Moringa Oleifera Ameliorates Cardiotoxicity and Improves Antioxidants in Breast Cancer- induced Rats Treated with Doxorubicin: A Preliminary Study.

Moringa Oleifera (MO) is a miracle plant of huge medical significance. It could be used to suppress the aggressiveness of various tumors as well as ameliorate the consequences of chemotherapeutic agents. In the present study; 49 albino rats were used to evaluate the effect of MO nanoparticles (MONP...

Full description

Bibliographic Details
Main Authors: Rehab A.M. Gouda, Abeer G. Ali Hassan, Yasmina K. Mahmoud, Ibrahim A. Ibrahim
Format: Article
Language:English
Published: Assiut University 2023-12-01
Series:Journal of Advanced Veterinary Research
Subjects:
Online Access:https://advetresearch.com/index.php/AVR/article/view/1605
Description
Summary:Moringa Oleifera (MO) is a miracle plant of huge medical significance. It could be used to suppress the aggressiveness of various tumors as well as ameliorate the consequences of chemotherapeutic agents. In the present study; 49 albino rats were used to evaluate the effect of MO nanoparticles (MONPs) in DMBA-induced breast cancer rats (BC-induced) treated with doxorubicin (DOX). Cardiotoxicity, antioxidant markers, and protein profile were evaluated. Serum and mammary glands samples were collected for both biochemical and histopathological examinations. Rats were classified into control and BC-induced rats. The last group was further divided into 6 groups to evaluate the synergistic and prophylactic effects of MONPs. There was a significant reduction in the levels of tumor, and cardiotoxicity markers with a significant increase in the antioxidants/oxidants and proteins profile in BC-induced rats treated synergistically or/and prophylactically with MONPs and DOX. In conclusion, the prophylactic use of MONPs and synergistic use of MONPs and DOX induced a magnificent resistance against cardiotoxicity induced by doxorubicin and ameliorated the aggressiveness of breast cancer as well as the oxidative stress induced in rats.
ISSN:2090-6269
2090-6277