Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells
Leukemic stem cells which are resistant to chemotherapy are proposed as relapse-initiating cells (RICs). Here, the authors show that targeting the adrenomedullin-calcitonin receptor-like receptor decreases RICs frequency improving chemotherapy response in AML preclinical models.
Bibliographic Details
| Main Authors: |
Clément Larrue,
Nathan Guiraud,
Pierre-Luc Mouchel,
Marine Dubois,
Thomas Farge,
Mathilde Gotanègre,
Claudie Bosc,
Estelle Saland,
Marie-Laure Nicolau-Travers,
Marie Sabatier,
Nizar Serhan,
Ambrine Sahal,
Emeline Boet,
Sarah Mouche,
Quentin Heydt,
Nesrine Aroua,
Lucille Stuani,
Tony Kaoma,
Linus Angenendt,
Jan-Henrik Mikesch,
Christoph Schliemann,
François Vergez,
Jérôme Tamburini,
Christian Récher,
Jean-Emmanuel Sarry |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-20717-9
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