Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review
Background: In recent years, the potential role of probiotics has become prominent in the discoveries of neurotherapy against neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. Lactic acid bacteria (LAB) exhibit neuroprotective properties and exert their effects via various me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/5/712 |
| _version_ | 1827740432126181376 |
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| author | Nurliana Abd Mutalib Sharifah Aminah Syed Mohamad Nor Atiqah Jusril Nur Intan Hasbullah Mohd Cairul Iqbal Mohd Amin Nor Hadiani Ismail |
| author_facet | Nurliana Abd Mutalib Sharifah Aminah Syed Mohamad Nor Atiqah Jusril Nur Intan Hasbullah Mohd Cairul Iqbal Mohd Amin Nor Hadiani Ismail |
| author_sort | Nurliana Abd Mutalib |
| collection | DOAJ |
| description | Background: In recent years, the potential role of probiotics has become prominent in the discoveries of neurotherapy against neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. Lactic acid bacteria (LAB) exhibit neuroprotective properties and exert their effects via various mechanisms of actions. This review aimed to evaluate the effects of LAB on neuroprotection reported in the literature. Methods: A database search on Google Scholar, PubMed, and Science Direct revealed a total of 467 references, of which 25 were included in this review based on inclusion criteria which comprises 7 in vitro, 16 in vivo, and 2 clinical studies. Results: From the studies, LAB treatment alone or in probiotics formulations demonstrated significant neuroprotective activities. In animals and humans, LAB probiotics supplementation has improved memory and cognitive performance mainly via antioxidant and anti-inflammatory pathways. Conclusions: Despite promising findings, due to limited studies available in the literature, further studies still need to be explored regarding synergistic effects, efficacy, and optimum dosage of LAB oral bacteriotherapy as treatment or prevention against neurodegenerative diseases. |
| first_indexed | 2024-03-11T03:25:55Z |
| format | Article |
| id | doaj.art-e5dcfdba8a844e3f912d1df51e21a6ab |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T03:25:55Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-e5dcfdba8a844e3f912d1df51e21a6ab2023-11-18T02:48:49ZengMDPI AGPharmaceuticals1424-82472023-05-0116571210.3390/ph16050712Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic ReviewNurliana Abd Mutalib0Sharifah Aminah Syed Mohamad1Nor Atiqah Jusril2Nur Intan Hasbullah3Mohd Cairul Iqbal Mohd Amin4Nor Hadiani Ismail5Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA Cawangan Selangor, Puncak Alam 42300, Selangor, MalaysiaAtta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA Cawangan Selangor, Puncak Alam 42300, Selangor, MalaysiaFaculty Bioresources and Food Industry, Universiti Sultan Zainal Abidin, Besut Campus, Besut 22200, Terengganu, MalaysiaAtta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA Cawangan Selangor, Puncak Alam 42300, Selangor, MalaysiaCentre for Drug Delivery Technology, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Selangor, MalaysiaAtta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA Cawangan Selangor, Puncak Alam 42300, Selangor, MalaysiaBackground: In recent years, the potential role of probiotics has become prominent in the discoveries of neurotherapy against neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. Lactic acid bacteria (LAB) exhibit neuroprotective properties and exert their effects via various mechanisms of actions. This review aimed to evaluate the effects of LAB on neuroprotection reported in the literature. Methods: A database search on Google Scholar, PubMed, and Science Direct revealed a total of 467 references, of which 25 were included in this review based on inclusion criteria which comprises 7 in vitro, 16 in vivo, and 2 clinical studies. Results: From the studies, LAB treatment alone or in probiotics formulations demonstrated significant neuroprotective activities. In animals and humans, LAB probiotics supplementation has improved memory and cognitive performance mainly via antioxidant and anti-inflammatory pathways. Conclusions: Despite promising findings, due to limited studies available in the literature, further studies still need to be explored regarding synergistic effects, efficacy, and optimum dosage of LAB oral bacteriotherapy as treatment or prevention against neurodegenerative diseases.https://www.mdpi.com/1424-8247/16/5/712lactic acid bacteriaLABprobioticsneuroprotectionneurodegenerative diseasesAlzheimer’s |
| spellingShingle | Nurliana Abd Mutalib Sharifah Aminah Syed Mohamad Nor Atiqah Jusril Nur Intan Hasbullah Mohd Cairul Iqbal Mohd Amin Nor Hadiani Ismail Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review Pharmaceuticals lactic acid bacteria LAB probiotics neuroprotection neurodegenerative diseases Alzheimer’s |
| title | Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review |
| title_full | Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review |
| title_fullStr | Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review |
| title_full_unstemmed | Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review |
| title_short | Lactic Acid Bacteria (LAB) and Neuroprotection, What Is New? An Up-To-Date Systematic Review |
| title_sort | lactic acid bacteria lab and neuroprotection what is new an up to date systematic review |
| topic | lactic acid bacteria LAB probiotics neuroprotection neurodegenerative diseases Alzheimer’s |
| url | https://www.mdpi.com/1424-8247/16/5/712 |
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