Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection.
BACKGROUND: Inter-alpha inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentratio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2850310?pdf=render |
| _version_ | 1818016788092289024 |
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| author | Penelope Koraka Yow-Pin Lim Michael D Shin Tatty E Setiati Albert T A Mairuhu Eric C M van Gorp Augustinus Soemantri Albert D M E Osterhaus Byron E E Martina |
| author_facet | Penelope Koraka Yow-Pin Lim Michael D Shin Tatty E Setiati Albert T A Mairuhu Eric C M van Gorp Augustinus Soemantri Albert D M E Osterhaus Byron E E Martina |
| author_sort | Penelope Koraka |
| collection | DOAJ |
| description | BACKGROUND: Inter-alpha inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp during DENV infections and evaluated its potential as a biomarker. METHODS AND FINDINGS: Concentrations of IaIp were measured in patients with acute DENV infections using a quantitative, competitive enzyme linked immunoassay. Concentrations of IaIp measured in pediatric patients suffering from severe DENV infections were significantly lower than in healthy controls. CONCLUSIONS: This is the first report to demonstrate changes in concentration of IaIp during viral infections. The data also highlight the potential of IaIp as a biological marker for severity of DENV infections. |
| first_indexed | 2024-04-14T07:18:18Z |
| format | Article |
| id | doaj.art-e5de49ac95854156abac3e7262eaba2c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T07:18:18Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e5de49ac95854156abac3e7262eaba2c2022-12-22T02:06:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-0154e996710.1371/journal.pone.0009967Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection.Penelope KorakaYow-Pin LimMichael D ShinTatty E SetiatiAlbert T A MairuhuEric C M van GorpAugustinus SoemantriAlbert D M E OsterhausByron E E MartinaBACKGROUND: Inter-alpha inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp during DENV infections and evaluated its potential as a biomarker. METHODS AND FINDINGS: Concentrations of IaIp were measured in patients with acute DENV infections using a quantitative, competitive enzyme linked immunoassay. Concentrations of IaIp measured in pediatric patients suffering from severe DENV infections were significantly lower than in healthy controls. CONCLUSIONS: This is the first report to demonstrate changes in concentration of IaIp during viral infections. The data also highlight the potential of IaIp as a biological marker for severity of DENV infections.http://europepmc.org/articles/PMC2850310?pdf=render |
| spellingShingle | Penelope Koraka Yow-Pin Lim Michael D Shin Tatty E Setiati Albert T A Mairuhu Eric C M van Gorp Augustinus Soemantri Albert D M E Osterhaus Byron E E Martina Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection. PLoS ONE |
| title | Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection. |
| title_full | Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection. |
| title_fullStr | Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection. |
| title_full_unstemmed | Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection. |
| title_short | Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection. |
| title_sort | plasma levels of inter alpha inhibitor proteins in children with acute dengue virus infection |
| url | http://europepmc.org/articles/PMC2850310?pdf=render |
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