Effects of intra-operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults; An observational study
Background: The occurrence of emergence agitation (EA) is the most common and practical problem faced in the immediate post-operative period during the process of Extubation under General Anaesthesia. Dexmedetomidine, an α2 adrenoceptor agonist is an excellent drug that has been shown effective to d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2023-09-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/54247 |
| _version_ | 1797727817742417920 |
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| author | Ghulam Jeelani Bhat Iqra Nazir Naqash Abdul Qayoom Lone Faizah Mufti Farooq Ahmad Ganie Altaf Hussain Mir Reyaz Qadri |
| author_facet | Ghulam Jeelani Bhat Iqra Nazir Naqash Abdul Qayoom Lone Faizah Mufti Farooq Ahmad Ganie Altaf Hussain Mir Reyaz Qadri |
| author_sort | Ghulam Jeelani Bhat |
| collection | DOAJ |
| description | Background: The occurrence of emergence agitation (EA) is the most common and practical problem faced in the immediate post-operative period during the process of Extubation under General Anaesthesia. Dexmedetomidine, an α2 adrenoceptor agonist is an excellent drug that has been shown effective to decrease the preoperative anxiety and smooth induction and emergence.
Aims and Objectives: To assess the effect of intravenous dexmedetomidine primarily on EA and other complications that may occur during emergence from general anesthesia.
Materials and Methods: 80 patients of either gender aged 18–65 years with ASA status I and II, undergoing various elective general and urological surgeries under general anesthesia were included in the study. Patients receiving adjuvant drug dexmedetomidine, were labelled as Group D (n=40) and those who didn’t receive any adjuvant were labelled as group C (n=40). Dexmedetomidine was given at 1 μg/kg and then maintained at infusion of 0.4 μg/kg/h till the end of the surgery for group D. The hemodynamic parameters and SpO2 were measured during the intraoperative period at various intervals of time till the end of surgery and also on arrival to the recovery room till patient was discharged from post-anesthesia care unit in both the groups.
Results: The use of IV dexmedetomidine has proved significantly effective in prevention of incidence of EA with the overall incidence of agitation of 7.5% in Group D as compared to 42.5% in group C.
Conclusion: Intraoperative administration of intravenous dexmedetomidine decreased the incidence of EA and other emergence phenomena like cough, pain and PONV with stable hemodynamics, safety profile, good analgesic properties and opioids sparing side effects. |
| first_indexed | 2024-03-12T11:04:56Z |
| format | Article |
| id | doaj.art-e5dfd8038dae49ee968aba78b64f454c |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-12T11:04:56Z |
| publishDate | 2023-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-e5dfd8038dae49ee968aba78b64f454c2023-09-02T04:07:11ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-09-011497682https://doi.org/10.3126/ajms.v14i9.54247Effects of intra-operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults; An observational studyGhulam Jeelani Bhat 0https://orcid.org/0009-0007-0192-0502Iqra Nazir Naqash 1https://orcid.org/0009-0008-3535-5158Abdul Qayoom Lone 2https://orcid.org/0009-0007-2893-3047Faizah Mufti 3https://orcid.org/0000-0003-2745-1103Farooq Ahmad Ganie 4https://orcid.org/0000-0002-7994-2775Altaf Hussain Mir 5https://orcid.org/0009-0003-8684-1854Reyaz Qadri 6https://orcid.org/0009-0006-5865-1254Senior Resident, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Associate Professor, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Professor, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Senior Resident, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Associate Professor, Department of Cardiothoracic and Vascular Surgery, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Assistant Professor, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Senior Resident, Department of Anaesthesiology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Background: The occurrence of emergence agitation (EA) is the most common and practical problem faced in the immediate post-operative period during the process of Extubation under General Anaesthesia. Dexmedetomidine, an α2 adrenoceptor agonist is an excellent drug that has been shown effective to decrease the preoperative anxiety and smooth induction and emergence. Aims and Objectives: To assess the effect of intravenous dexmedetomidine primarily on EA and other complications that may occur during emergence from general anesthesia. Materials and Methods: 80 patients of either gender aged 18–65 years with ASA status I and II, undergoing various elective general and urological surgeries under general anesthesia were included in the study. Patients receiving adjuvant drug dexmedetomidine, were labelled as Group D (n=40) and those who didn’t receive any adjuvant were labelled as group C (n=40). Dexmedetomidine was given at 1 μg/kg and then maintained at infusion of 0.4 μg/kg/h till the end of the surgery for group D. The hemodynamic parameters and SpO2 were measured during the intraoperative period at various intervals of time till the end of surgery and also on arrival to the recovery room till patient was discharged from post-anesthesia care unit in both the groups. Results: The use of IV dexmedetomidine has proved significantly effective in prevention of incidence of EA with the overall incidence of agitation of 7.5% in Group D as compared to 42.5% in group C. Conclusion: Intraoperative administration of intravenous dexmedetomidine decreased the incidence of EA and other emergence phenomena like cough, pain and PONV with stable hemodynamics, safety profile, good analgesic properties and opioids sparing side effects.https://www.nepjol.info/index.php/AJMS/article/view/54247dexmedetomidine; emergence agitation; general anaesthesia; extubation |
| spellingShingle | Ghulam Jeelani Bhat Iqra Nazir Naqash Abdul Qayoom Lone Faizah Mufti Farooq Ahmad Ganie Altaf Hussain Mir Reyaz Qadri Effects of intra-operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults; An observational study Asian Journal of Medical Sciences dexmedetomidine; emergence agitation; general anaesthesia; extubation |
| title | Effects of intra-operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults; An observational study |
| title_full | Effects of intra-operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults; An observational study |
| title_fullStr | Effects of intra-operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults; An observational study |
| title_full_unstemmed | Effects of intra-operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults; An observational study |
| title_short | Effects of intra-operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults; An observational study |
| title_sort | effects of intra operative administration of intravenous dexmedetomidine on incidence of emergence phenomenon after general anaesthesia in adults an observational study |
| topic | dexmedetomidine; emergence agitation; general anaesthesia; extubation |
| url | https://www.nepjol.info/index.php/AJMS/article/view/54247 |
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