Efficient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones via a Three-Component Biginelli Reaction

Efficient One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones via a Three-Component Biginelli Reaction

Multicomponent reactions are considered to be of increasing importance as time progresses due to the economic and environmental advantages such strategies entail. The three-component Biginelli reaction involves the combination of an aldehyde, a β-ketoester and urea to produce 3,4-dihydropyrimidin-2(...

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Bibliographic Details
Main Authors: Giovanna Bosica, Fiona Cachia, Riccardo De Nittis, Nicole Mariotti
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
Biginelli reaction
multicomponent reaction
heterogeneous catalysis
solvent-free
supported heteropoly acid
one-pot
Online Access:https://www.mdpi.com/1420-3049/26/12/3753

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