The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Introduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of hyponatremia in cancer patients, occurring most frequently in patients with small cell lung cancer. However, this syndrome occurs extremely rarely in patients with non-small cell lung cance...
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MDPI AG
2023-05-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/6/1279 |
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| author | Roxana-Andreea Rahnea-Nita Alexandru-Rares Stoian Rodica-Maricela Anghel Laura-Florentina Rebegea Anda-Natalia Ciuhu Xenia-Elena Bacinschi Anca-Florina Zgura Oana-Gabriela Trifanescu Radu-Valeriu Toma Georgiana Bianca Constantin Gabriela Rahnea-Nita |
| author_facet | Roxana-Andreea Rahnea-Nita Alexandru-Rares Stoian Rodica-Maricela Anghel Laura-Florentina Rebegea Anda-Natalia Ciuhu Xenia-Elena Bacinschi Anca-Florina Zgura Oana-Gabriela Trifanescu Radu-Valeriu Toma Georgiana Bianca Constantin Gabriela Rahnea-Nita |
| author_sort | Roxana-Andreea Rahnea-Nita |
| collection | DOAJ |
| description | Introduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of hyponatremia in cancer patients, occurring most frequently in patients with small cell lung cancer. However, this syndrome occurs extremely rarely in patients with non-small cell lung cancer. The results of the clinical trials have revealed that immuno-oncological therapies are effective for long periods of time, providing hope for long survival and with a good quality of life. Case Presentation: We present the case of a female patient who was 62 years old at the time of diagnosis in 2016 who underwent surgery for a right pulmonary tumor (pulmonary adenocarcinoma) and subsequently underwent adjuvant chemotherapy. The patient had a left inoperable mediastinohilar relapse in 2018, which was treated using polychemotherapy The patient also had an occurrence of progressive metastasis and a syndrome of inappropriate antidiuretic hormone secretion (SIADH) in 2019 for which immunotherapy was initiated. The patient has continued with immunotherapy until the time this study began to be written (April 2023), the results being the remission of hyponatremia, the clinical benefits and long-term survival. Discussion: The main therapeutic option for SIADH in cancer patients is the treatment of the underlying disease, and its correction depends almost exclusively on a good response to oncological therapy. The initiation of immunotherapy at the time of severe hyponatremia occurrence led to its remission as well as the remission of the other two episodes of hyponatremia, which the patient presented throughout the evolution of the disease, demonstrating an obvious causal relationship between SIADH and the favorable response to immunotherapy. Conclusions: Each patient must be approached individually, taking into account the various particular aspects. Immunotherapy proves to be the innovative treatment that contributes to increasing the survival of patients with metastatic non-small cell lung cancer and to increasing their quality of life. |
| first_indexed | 2024-03-11T02:14:57Z |
| format | Article |
| id | doaj.art-e5e34cb11a60486f901179345f1e1f4f |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T02:14:57Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj.art-e5e34cb11a60486f901179345f1e1f4f2023-11-18T11:17:06ZengMDPI AGLife2075-17292023-05-01136127910.3390/life13061279The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)Roxana-Andreea Rahnea-Nita0Alexandru-Rares Stoian1Rodica-Maricela Anghel2Laura-Florentina Rebegea3Anda-Natalia Ciuhu4Xenia-Elena Bacinschi5Anca-Florina Zgura6Oana-Gabriela Trifanescu7Radu-Valeriu Toma8Georgiana Bianca Constantin9Gabriela Rahnea-Nita10The Clinical Department, The Faculty of Medicine, The University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaThe Clinical Department, The Faculty of Medicine, The University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaThe Clinical Department, The Faculty of Medicine, The University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaThe Radiotherapy Department, “Sf. Ap. Andrei” County Emergency Clinical Hospital, 800579 Galati, Romania“Sf. Luca” Chronic Disease Hospital, 041915 Bucharest, RomaniaThe Clinical Department, The Faculty of Medicine, The University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaThe Clinical Department, The Faculty of Medicine, The University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaThe Clinical Department, The Faculty of Medicine, The University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaThe Clinical Department, The Faculty of Medicine, The University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaThe Morphological and Functional Sciences Department, The Faculty of Medicine and Pharmacy, “Dunarea de Jos” University in Galati, 800008 Galati, RomaniaThe Clinical Department, The Faculty of Medicine, The University of Medicine and Pharmacy “Carol Davila”, 050474 Bucharest, RomaniaIntroduction: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of hyponatremia in cancer patients, occurring most frequently in patients with small cell lung cancer. However, this syndrome occurs extremely rarely in patients with non-small cell lung cancer. The results of the clinical trials have revealed that immuno-oncological therapies are effective for long periods of time, providing hope for long survival and with a good quality of life. Case Presentation: We present the case of a female patient who was 62 years old at the time of diagnosis in 2016 who underwent surgery for a right pulmonary tumor (pulmonary adenocarcinoma) and subsequently underwent adjuvant chemotherapy. The patient had a left inoperable mediastinohilar relapse in 2018, which was treated using polychemotherapy The patient also had an occurrence of progressive metastasis and a syndrome of inappropriate antidiuretic hormone secretion (SIADH) in 2019 for which immunotherapy was initiated. The patient has continued with immunotherapy until the time this study began to be written (April 2023), the results being the remission of hyponatremia, the clinical benefits and long-term survival. Discussion: The main therapeutic option for SIADH in cancer patients is the treatment of the underlying disease, and its correction depends almost exclusively on a good response to oncological therapy. The initiation of immunotherapy at the time of severe hyponatremia occurrence led to its remission as well as the remission of the other two episodes of hyponatremia, which the patient presented throughout the evolution of the disease, demonstrating an obvious causal relationship between SIADH and the favorable response to immunotherapy. Conclusions: Each patient must be approached individually, taking into account the various particular aspects. Immunotherapy proves to be the innovative treatment that contributes to increasing the survival of patients with metastatic non-small cell lung cancer and to increasing their quality of life.https://www.mdpi.com/2075-1729/13/6/1279non-small cell lung cancersyndrome of inappropriate antidiuretic hormone secretionimmunotherapylong-term survival |
| spellingShingle | Roxana-Andreea Rahnea-Nita Alexandru-Rares Stoian Rodica-Maricela Anghel Laura-Florentina Rebegea Anda-Natalia Ciuhu Xenia-Elena Bacinschi Anca-Florina Zgura Oana-Gabriela Trifanescu Radu-Valeriu Toma Georgiana Bianca Constantin Gabriela Rahnea-Nita The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Life non-small cell lung cancer syndrome of inappropriate antidiuretic hormone secretion immunotherapy long-term survival |
| title | The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) |
| title_full | The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) |
| title_fullStr | The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) |
| title_full_unstemmed | The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) |
| title_short | The Efficacy of Immunotherapy in Long-Term Survival in Non-Small Cell Lung Cancer (NSCLC) Associated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) |
| title_sort | efficacy of immunotherapy in long term survival in non small cell lung cancer nsclc associated with the syndrome of inappropriate antidiuretic hormone secretion siadh |
| topic | non-small cell lung cancer syndrome of inappropriate antidiuretic hormone secretion immunotherapy long-term survival |
| url | https://www.mdpi.com/2075-1729/13/6/1279 |
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