Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells
The tumor microenvironment (TME), the ''soil'' on which tumor cells grow, has an important role in regulating the proliferation and metastasis of tumor cells as well as their response to treatment. Cancer-associated fibroblasts (CAFs), as the most abundant stromal cells of the TM...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223014208 |
| _version_ | 1797660543123718144 |
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| author | Dandan Gao Liguang Fang Cun Liu Mengrui Yang Xiaoyun Yu Longyun Wang Wenfeng Zhang Changgang Sun Jing Zhuang |
| author_facet | Dandan Gao Liguang Fang Cun Liu Mengrui Yang Xiaoyun Yu Longyun Wang Wenfeng Zhang Changgang Sun Jing Zhuang |
| author_sort | Dandan Gao |
| collection | DOAJ |
| description | The tumor microenvironment (TME), the ''soil'' on which tumor cells grow, has an important role in regulating the proliferation and metastasis of tumor cells as well as their response to treatment. Cancer-associated fibroblasts (CAFs), as the most abundant stromal cells of the TME, can not only directly alter the immunosuppressive effect of the TME through their own metabolism, but also influence the aggregation and function of immune cells by secreting a large number of cytokines and chemokines, reducing the body’s immune surveillance of tumor cells and making them more prone to immune escape. Our study provides a comprehensive review of fibroblast chemotaxis, malignant transformation, metabolic characteristics, and interactions with immune cells. In addition, the current small molecule drugs targeting CAFs have been summarized, including both natural small molecules and targeted drugs for current clinical therapeutic applications. A complete review of the role of fibroblasts in TME from an immune perspective is presented, which has important implications in improving the efficiency of immunotherapy by targeting fibroblasts. |
| first_indexed | 2024-03-11T18:32:23Z |
| format | Article |
| id | doaj.art-e5e46d855e16458283f282730da8e3cd |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:32:23Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-e5e46d855e16458283f282730da8e3cd2023-10-13T11:03:21ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-01167115622Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cellsDandan Gao0Liguang Fang1Cun Liu2Mengrui Yang3Xiaoyun Yu4Longyun Wang5Wenfeng Zhang6Changgang Sun7Jing Zhuang8College of Traditional Chinese Medicine, Weifang Medical University, Weifang 261000, ChinaCollege of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Traditional Chinese Medicine, Weifang Medical University, Weifang 261000, ChinaCollege of Traditional Chinese Medicine, Weifang Medical University, Weifang 261000, ChinaCollege of Traditional Chinese Medicine, Weifang Medical University, Weifang 261000, ChinaState Key Laboratory of Quality Research in Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of ChinaState Key Laboratory of Quality Research in Chinese Medicine and Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of ChinaCollege of Traditional Chinese Medicine, Weifang Medical University, Weifang 261000, China; Department of Oncology, Weifang Traditional Chinese Hospital, Weifang 261000, China; Corresponding author at: College of Traditional Chinese Medicine, Weifang Medical University, Weifang 261000, China.Department of Oncology, Weifang Traditional Chinese Hospital, Weifang 261000, China; Corresponding author.The tumor microenvironment (TME), the ''soil'' on which tumor cells grow, has an important role in regulating the proliferation and metastasis of tumor cells as well as their response to treatment. Cancer-associated fibroblasts (CAFs), as the most abundant stromal cells of the TME, can not only directly alter the immunosuppressive effect of the TME through their own metabolism, but also influence the aggregation and function of immune cells by secreting a large number of cytokines and chemokines, reducing the body’s immune surveillance of tumor cells and making them more prone to immune escape. Our study provides a comprehensive review of fibroblast chemotaxis, malignant transformation, metabolic characteristics, and interactions with immune cells. In addition, the current small molecule drugs targeting CAFs have been summarized, including both natural small molecules and targeted drugs for current clinical therapeutic applications. A complete review of the role of fibroblasts in TME from an immune perspective is presented, which has important implications in improving the efficiency of immunotherapy by targeting fibroblasts.http://www.sciencedirect.com/science/article/pii/S0753332223014208Tumor microenvironmentCancer-associated fibroblastsImmune cellsTreatment |
| spellingShingle | Dandan Gao Liguang Fang Cun Liu Mengrui Yang Xiaoyun Yu Longyun Wang Wenfeng Zhang Changgang Sun Jing Zhuang Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells Biomedicine & Pharmacotherapy Tumor microenvironment Cancer-associated fibroblasts Immune cells Treatment |
| title | Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells |
| title_full | Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells |
| title_fullStr | Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells |
| title_full_unstemmed | Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells |
| title_short | Microenvironmental regulation in tumor progression: Interactions between cancer-associated fibroblasts and immune cells |
| title_sort | microenvironmental regulation in tumor progression interactions between cancer associated fibroblasts and immune cells |
| topic | Tumor microenvironment Cancer-associated fibroblasts Immune cells Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223014208 |
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