A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover Trial
When healthy adults consume carbohydrates at night, postprandial blood glucose responses are elevated and prolonged compared to daytime.Extended postprandial hyperglycaemia is a risk factor for type 2 diabetes. Polyphenols are bioactive secondary metabolites of plants and algae with potential to mod...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/2/49 |
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| author | Margaret Murray Aimee L. Dordevic Lisa Ryan Maxine P. Bonham |
| author_facet | Margaret Murray Aimee L. Dordevic Lisa Ryan Maxine P. Bonham |
| author_sort | Margaret Murray |
| collection | DOAJ |
| description | When healthy adults consume carbohydrates at night, postprandial blood glucose responses are elevated and prolonged compared to daytime.Extended postprandial hyperglycaemia is a risk factor for type 2 diabetes. Polyphenols are bioactive secondary metabolites of plants and algae with potential to moderate postprandial glycaemia. This study investigated whether a polyphenol-rich alga (<i>Fucus vesiculosus</i>) extract moderated postprandial glycaemia in the evening in healthy adults. In a double blind, placebo-controlled, randomised three-way crossover trial, 18 participants consumed a polyphenol-rich extract, a cellulose placebo and rice flour placebo (7:15 p.m.) prior to 50 g available carbohydrate from bread (7:45 p.m.), followed by three hours of blood sampling to assess glucose and insulin. A subset of participants (<i>n</i> = 8) completed the same protocol once in the morning with only the cellulose placebo (7:15 a.m.). No effect of the polyphenol-rich extract was observed on postprandial glycaemia in the evening, compared with placebos, in the group as a whole. However, in females only, peak blood glucose concentration was reduced following the polyphenol-rich extract. In the subset analysis, as expected, participants exhibited elevated postprandial blood glucose in the evening compared with the morning following the cellulose placebo. This was the first study to investigate whether a polyphenol intervention moderated evening postprandial hyperglycaemia. The lowering effect observed in females suggests that this warrants further investigation. |
| first_indexed | 2024-03-12T06:17:15Z |
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| id | doaj.art-e5e47d84748f40e9a82a4595d819a5e3 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T06:17:15Z |
| publishDate | 2019-02-01 |
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| series | Antioxidants |
| spelling | doaj.art-e5e47d84748f40e9a82a4595d819a5e32023-09-03T02:30:49ZengMDPI AGAntioxidants2076-39212019-02-01824910.3390/antiox8020049antiox8020049A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover TrialMargaret Murray0Aimee L. Dordevic1Lisa Ryan2Maxine P. Bonham3Department of Nutrition, Dietetics and Food, Monash University, Notting Hill VIC 3168, AustraliaDepartment of Nutrition, Dietetics and Food, Monash University, Notting Hill VIC 3168, AustraliaSchool of Science and Computing, Galway-Mayo Institute of Technology, Galway H91 T8NW, IrelandDepartment of Nutrition, Dietetics and Food, Monash University, Notting Hill VIC 3168, AustraliaWhen healthy adults consume carbohydrates at night, postprandial blood glucose responses are elevated and prolonged compared to daytime.Extended postprandial hyperglycaemia is a risk factor for type 2 diabetes. Polyphenols are bioactive secondary metabolites of plants and algae with potential to moderate postprandial glycaemia. This study investigated whether a polyphenol-rich alga (<i>Fucus vesiculosus</i>) extract moderated postprandial glycaemia in the evening in healthy adults. In a double blind, placebo-controlled, randomised three-way crossover trial, 18 participants consumed a polyphenol-rich extract, a cellulose placebo and rice flour placebo (7:15 p.m.) prior to 50 g available carbohydrate from bread (7:45 p.m.), followed by three hours of blood sampling to assess glucose and insulin. A subset of participants (<i>n</i> = 8) completed the same protocol once in the morning with only the cellulose placebo (7:15 a.m.). No effect of the polyphenol-rich extract was observed on postprandial glycaemia in the evening, compared with placebos, in the group as a whole. However, in females only, peak blood glucose concentration was reduced following the polyphenol-rich extract. In the subset analysis, as expected, participants exhibited elevated postprandial blood glucose in the evening compared with the morning following the cellulose placebo. This was the first study to investigate whether a polyphenol intervention moderated evening postprandial hyperglycaemia. The lowering effect observed in females suggests that this warrants further investigation.https://www.mdpi.com/2076-3921/8/2/49glucoseinsulinpolyphenolcircadian rhythmnightalgaehyperglycaemiahyperinsulinaemia |
| spellingShingle | Margaret Murray Aimee L. Dordevic Lisa Ryan Maxine P. Bonham A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover Trial Antioxidants glucose insulin polyphenol circadian rhythm night algae hyperglycaemia hyperinsulinaemia |
| title | A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover Trial |
| title_full | A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover Trial |
| title_fullStr | A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover Trial |
| title_full_unstemmed | A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover Trial |
| title_short | A Single-Dose of a Polyphenol-Rich Fucus Vesiculosus Extract is Insufficient to Blunt the Elevated Postprandial Blood Glucose Responses Exhibited by Healthy Adults in the Evening: A Randomised Crossover Trial |
| title_sort | single dose of a polyphenol rich fucus vesiculosus extract is insufficient to blunt the elevated postprandial blood glucose responses exhibited by healthy adults in the evening a randomised crossover trial |
| topic | glucose insulin polyphenol circadian rhythm night algae hyperglycaemia hyperinsulinaemia |
| url | https://www.mdpi.com/2076-3921/8/2/49 |
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