Antimicrobial Resistance Profile of Group B <i>Streptococci</i> Colonization in a Sample Population of Pregnant Women from Romania
Group B <i>Streptococcus</i> (GBS) represents one of the leading causes of life-threatening invasive disease in pregnant women and neonates. Rates of GBS colonization vary by region, but studies on maternal GBS status are limited in Romania. This study aims to identify the prevalence of...
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MDPI AG
2024-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/2/414 |
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| author | Aida Petca Florica Șandru Silvius Negoiță Mihai Cristian Dumitrașcu Daiana Anne-Marie Dimcea Tiberiu Nedelcu Claudia Mehedințu Marinela Magdalena Filipov Răzvan-Cosmin Petca |
| author_facet | Aida Petca Florica Șandru Silvius Negoiță Mihai Cristian Dumitrașcu Daiana Anne-Marie Dimcea Tiberiu Nedelcu Claudia Mehedințu Marinela Magdalena Filipov Răzvan-Cosmin Petca |
| author_sort | Aida Petca |
| collection | DOAJ |
| description | Group B <i>Streptococcus</i> (GBS) represents one of the leading causes of life-threatening invasive disease in pregnant women and neonates. Rates of GBS colonization vary by region, but studies on maternal GBS status are limited in Romania. This study aims to identify the prevalence of colonization with GBS and whether the obstetrical characteristics are statistically associated with the study group’s antimicrobial susceptibility patterns of tested GBS strains. This observational study was conducted between 1 May and 31 December 2021 at The Department of Obstetrics and Gynecology at Elias University Emergency Hospital (EUEH) in Bucharest, Romania. A total of 152 samples were positive for GBS and included in the study according to the inclusion criteria. As a result, the prevalence of colonized patients with GBS was 17.3%. GBS isolated in this population had the highest resistance to erythromycin (<i>n</i> = 38; 25%), followed by clindamycin (<i>n</i> = 36; 23.7%). Regarding the susceptibility patterns of tested strains to penicillin, the 152 susceptible strains had MIC breakpoints less than 0.06 μg/μL. The susceptibility patterns of tested strains to linezolid indicated three resistant strains with low levels of resistance (MICs ranging between 2 and 3 μg/μL). Multidrug resistance (at least three antibiotic classes) was not observed. In conclusion, although GBS naturally displays sensitivity to penicillin, the exact bacterial susceptibility testing should be performed in all cases where second-line therapy is taken into consideration for treatment. We acknowledge the need for future actions to limit multidrug-resistant bacteria. |
| first_indexed | 2024-03-07T22:20:20Z |
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| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-07T22:20:20Z |
| publishDate | 2024-02-01 |
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| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-e5e56b54fa6641849828752b2f040d172024-02-23T15:28:28ZengMDPI AGMicroorganisms2076-26072024-02-0112241410.3390/microorganisms12020414Antimicrobial Resistance Profile of Group B <i>Streptococci</i> Colonization in a Sample Population of Pregnant Women from RomaniaAida Petca0Florica Șandru1Silvius Negoiță2Mihai Cristian Dumitrașcu3Daiana Anne-Marie Dimcea4Tiberiu Nedelcu5Claudia Mehedințu6Marinela Magdalena Filipov7Răzvan-Cosmin Petca8Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, RomaniaDepartment of Dermatology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Anesthesiology and Critical Care, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, RomaniaFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, RomaniaDepartment of Laboratory Medicine, Elias University Emergency Hospital, 17 Marasti Blvd., 011461 Bucharest, RomaniaDepartment of Urology, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, RomaniaGroup B <i>Streptococcus</i> (GBS) represents one of the leading causes of life-threatening invasive disease in pregnant women and neonates. Rates of GBS colonization vary by region, but studies on maternal GBS status are limited in Romania. This study aims to identify the prevalence of colonization with GBS and whether the obstetrical characteristics are statistically associated with the study group’s antimicrobial susceptibility patterns of tested GBS strains. This observational study was conducted between 1 May and 31 December 2021 at The Department of Obstetrics and Gynecology at Elias University Emergency Hospital (EUEH) in Bucharest, Romania. A total of 152 samples were positive for GBS and included in the study according to the inclusion criteria. As a result, the prevalence of colonized patients with GBS was 17.3%. GBS isolated in this population had the highest resistance to erythromycin (<i>n</i> = 38; 25%), followed by clindamycin (<i>n</i> = 36; 23.7%). Regarding the susceptibility patterns of tested strains to penicillin, the 152 susceptible strains had MIC breakpoints less than 0.06 μg/μL. The susceptibility patterns of tested strains to linezolid indicated three resistant strains with low levels of resistance (MICs ranging between 2 and 3 μg/μL). Multidrug resistance (at least three antibiotic classes) was not observed. In conclusion, although GBS naturally displays sensitivity to penicillin, the exact bacterial susceptibility testing should be performed in all cases where second-line therapy is taken into consideration for treatment. We acknowledge the need for future actions to limit multidrug-resistant bacteria.https://www.mdpi.com/2076-2607/12/2/414group B <i>Streptococcus</i>antimicrobial resistancepregnant women<i>Streptococcus agalactiae</i> |
| spellingShingle | Aida Petca Florica Șandru Silvius Negoiță Mihai Cristian Dumitrașcu Daiana Anne-Marie Dimcea Tiberiu Nedelcu Claudia Mehedințu Marinela Magdalena Filipov Răzvan-Cosmin Petca Antimicrobial Resistance Profile of Group B <i>Streptococci</i> Colonization in a Sample Population of Pregnant Women from Romania Microorganisms group B <i>Streptococcus</i> antimicrobial resistance pregnant women <i>Streptococcus agalactiae</i> |
| title | Antimicrobial Resistance Profile of Group B <i>Streptococci</i> Colonization in a Sample Population of Pregnant Women from Romania |
| title_full | Antimicrobial Resistance Profile of Group B <i>Streptococci</i> Colonization in a Sample Population of Pregnant Women from Romania |
| title_fullStr | Antimicrobial Resistance Profile of Group B <i>Streptococci</i> Colonization in a Sample Population of Pregnant Women from Romania |
| title_full_unstemmed | Antimicrobial Resistance Profile of Group B <i>Streptococci</i> Colonization in a Sample Population of Pregnant Women from Romania |
| title_short | Antimicrobial Resistance Profile of Group B <i>Streptococci</i> Colonization in a Sample Population of Pregnant Women from Romania |
| title_sort | antimicrobial resistance profile of group b i streptococci i colonization in a sample population of pregnant women from romania |
| topic | group B <i>Streptococcus</i> antimicrobial resistance pregnant women <i>Streptococcus agalactiae</i> |
| url | https://www.mdpi.com/2076-2607/12/2/414 |
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