Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants
Background and aims: It has been indicated that Melatonin receptor 1B (MTNR1B) gene rs10830963 C/G polymorphism was associated with the increased type 2 diabetes mellitus (T2DM) risk. Nevertheless, due to the inconsistent results among the individual studies on this topic, no consensus has been reac...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022030742 |
| _version_ | 1811213861266653184 |
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| author | Yan-yan Li Hui Wang Yang-yang Zhang |
| author_facet | Yan-yan Li Hui Wang Yang-yang Zhang |
| author_sort | Yan-yan Li |
| collection | DOAJ |
| description | Background and aims: It has been indicated that Melatonin receptor 1B (MTNR1B) gene rs10830963 C/G polymorphism was associated with the increased type 2 diabetes mellitus (T2DM) risk. Nevertheless, due to the inconsistent results among the individual studies on this topic, no consensus has been reached now. Hence, the present meta-analysis was conducted to illuminate the potential association of human MTNR1B gene rs10830963 C/G polymorphism and T2DM. Methods and results: There were 13,752 participants from 7 studies in the present meta-analysis. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed by using the fixed or random effects models. A significant association between MTNR1B gene rs10830963 C/G polymorphism and T2DM was found under recessive (OR: 1.148, 95% CI: 1.052–1.253, P = 0.002), homozygous (OR: 1.197, 95% CI: 1.023–1.401, P = 0.025), and additive (OR: 1.067, 95% CI: 1.017–1.120, P = 0.008) genetic models. Conclusions: MTNR1B gene rs10830963 C/G polymorphism was significantly related to T2DM in the Chinese population. The persons with G allele of the MTNRB1 gene rs10830963 C/G polymorphism might be the T2DM susceptible population. |
| first_indexed | 2024-04-12T05:53:22Z |
| format | Article |
| id | doaj.art-e5e5b51551ad4e2985f3851f19580058 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-12T05:53:22Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-e5e5b51551ad4e2985f3851f195800582022-12-22T03:45:13ZengElsevierHeliyon2405-84402022-11-01811e11786Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participantsYan-yan Li0Hui Wang1Yang-yang Zhang2Clinical Research Center, First Affiliated Hospital of Nanjing Medical University, NO.300 Guangzhou Road, Nanjing, Jiangsu, 210029, China; Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, NO.300 Guangzhou Road, Nanjing, Jiangsu, 210029, China; Corresponding author.Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, NO.300 Guangzhou Road, Nanjing, Jiangsu, 210029, ChinaDepartment of General Practice, First Affiliated Hospital of Nanjing Medical University, NO.300 Guangzhou Road, Nanjing, Jiangsu, 210029, ChinaBackground and aims: It has been indicated that Melatonin receptor 1B (MTNR1B) gene rs10830963 C/G polymorphism was associated with the increased type 2 diabetes mellitus (T2DM) risk. Nevertheless, due to the inconsistent results among the individual studies on this topic, no consensus has been reached now. Hence, the present meta-analysis was conducted to illuminate the potential association of human MTNR1B gene rs10830963 C/G polymorphism and T2DM. Methods and results: There were 13,752 participants from 7 studies in the present meta-analysis. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed by using the fixed or random effects models. A significant association between MTNR1B gene rs10830963 C/G polymorphism and T2DM was found under recessive (OR: 1.148, 95% CI: 1.052–1.253, P = 0.002), homozygous (OR: 1.197, 95% CI: 1.023–1.401, P = 0.025), and additive (OR: 1.067, 95% CI: 1.017–1.120, P = 0.008) genetic models. Conclusions: MTNR1B gene rs10830963 C/G polymorphism was significantly related to T2DM in the Chinese population. The persons with G allele of the MTNRB1 gene rs10830963 C/G polymorphism might be the T2DM susceptible population.http://www.sciencedirect.com/science/article/pii/S2405844022030742MTNR1Brs10830963PolymorphismType 2 diabetes mellitusGenetic |
| spellingShingle | Yan-yan Li Hui Wang Yang-yang Zhang Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants Heliyon MTNR1B rs10830963 Polymorphism Type 2 diabetes mellitus Genetic |
| title | Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants |
| title_full | Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants |
| title_fullStr | Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants |
| title_full_unstemmed | Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants |
| title_short | Melatonin receptor 1B gene rs10830963 C/G polymorphism associated with type 2 diabetes mellitus: An updated meta-analysis of 13,752 participants |
| title_sort | melatonin receptor 1b gene rs10830963 c g polymorphism associated with type 2 diabetes mellitus an updated meta analysis of 13 752 participants |
| topic | MTNR1B rs10830963 Polymorphism Type 2 diabetes mellitus Genetic |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022030742 |
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