Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication
Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin–monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/24/7493 |
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| author | Tatyana M. Khomenko Anna A. Shtro Anastasia V. Galochkina Yulia V. Nikolaeva Galina D. Petukhova Sophia S. Borisevich Dina V. Korchagina Konstantin P. Volcho Nariman F. Salakhutdinov |
| author_facet | Tatyana M. Khomenko Anna A. Shtro Anastasia V. Galochkina Yulia V. Nikolaeva Galina D. Petukhova Sophia S. Borisevich Dina V. Korchagina Konstantin P. Volcho Nariman F. Salakhutdinov |
| author_sort | Tatyana M. Khomenko |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin–monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target. |
| first_indexed | 2024-03-10T03:29:46Z |
| format | Article |
| id | doaj.art-e5e7a134896b4c53a951294e02ba79f7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:29:46Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e5e7a134896b4c53a951294e02ba79f72023-11-23T09:44:56ZengMDPI AGMolecules1420-30492021-12-012624749310.3390/molecules26247493Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) ReplicationTatyana M. Khomenko0Anna A. Shtro1Anastasia V. Galochkina2Yulia V. Nikolaeva3Galina D. Petukhova4Sophia S. Borisevich5Dina V. Korchagina6Konstantin P. Volcho7Nariman F. Salakhutdinov8Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, RussiaLaboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, RussiaLaboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, RussiaLaboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, RussiaLaboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, RussiaLaboratory of Physical Chemistry, Ufa Chemistry Institute of the Ufa Federal Research Center, 71 Octyabrya pr., 450054 Ufa, RussiaDepartment of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, RussiaDepartment of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, RussiaDepartment of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, RussiaRespiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin–monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target.https://www.mdpi.com/1420-3049/26/24/7493coumarinterpeneantiviral activitycytotoxicityrespiratory syncytial virusmolecular modelling |
| spellingShingle | Tatyana M. Khomenko Anna A. Shtro Anastasia V. Galochkina Yulia V. Nikolaeva Galina D. Petukhova Sophia S. Borisevich Dina V. Korchagina Konstantin P. Volcho Nariman F. Salakhutdinov Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication Molecules coumarin terpene antiviral activity cytotoxicity respiratory syncytial virus molecular modelling |
| title | Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication |
| title_full | Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication |
| title_fullStr | Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication |
| title_full_unstemmed | Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication |
| title_short | Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication |
| title_sort | monoterpene containing substituted coumarins as inhibitors of respiratory syncytial virus rsv replication |
| topic | coumarin terpene antiviral activity cytotoxicity respiratory syncytial virus molecular modelling |
| url | https://www.mdpi.com/1420-3049/26/24/7493 |
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