Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication

Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication

Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin–monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both...

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Bibliographic Details
Main Authors: Tatyana M. Khomenko, Anna A. Shtro, Anastasia V. Galochkina, Yulia V. Nikolaeva, Galina D. Petukhova, Sophia S. Borisevich, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
coumarin
terpene
antiviral activity
cytotoxicity
respiratory syncytial virus
molecular modelling
Online Access:https://www.mdpi.com/1420-3049/26/24/7493

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