Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report
<p>Abstract</p> <p>Background</p> <p>We previously reported a high prevalence (22.3%) of gestational diabetes mellitus (GDM) in a large group of Sardinian women, in contrast with the prevalence of Type 2 diabetes. Sardinia has an unusual distribution of haplotypes and g...
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Format: | Article |
Language: | English |
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BMC
2008-06-01
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Series: | Reproductive Biology and Endocrinology |
Online Access: | http://www.rbej.com/content/6/1/24 |
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author | Murenu Michela Sulis Simonetta Motzo Costantino Berria Rachele Zedda Pierina Garau Nicoletta Portoghese Elaine Orrù Marisa Murgia Cinzia Paoletti Anna Melis Gian |
author_facet | Murenu Michela Sulis Simonetta Motzo Costantino Berria Rachele Zedda Pierina Garau Nicoletta Portoghese Elaine Orrù Marisa Murgia Cinzia Paoletti Anna Melis Gian |
author_sort | Murenu Michela |
collection | DOAJ |
description | <p>Abstract</p> <p>Background</p> <p>We previously reported a high prevalence (22.3%) of gestational diabetes mellitus (GDM) in a large group of Sardinian women, in contrast with the prevalence of Type 2 diabetes. Sardinia has an unusual distribution of haplotypes and genotypes, with the highest population frequency of HLA DR3 in the world, and after Finland, the highest prevalence of Type 1 diabetes and Autoimmune-related Diseases. In this study we preliminarily tested the prevalence of serological markers of Type 1 diabetes in a group of Sardinian GDM patients.</p> <p>Methods</p> <p>We determined glutamic decarboxylase antibodies (anti-GAD65), protein tyrosine phosphatase ICA 512 (IA2) antibodies (anti-IA2), and IAA in 62 GDM patients, and in 56 controls with matching age, gestational age and parity.</p> <p>Results</p> <p>We found a high prevalence and very unusual distribution of antibodies in GDM patients (38.8%), the anti-IA2 being the most frequent antibody. Out of all our GDM patients, 38.8% (24 of 62) were positive for at least one antibody. Anti-IA2 was present in 29.0 % (18 out of 62) vs. 7.1% (4 out of 56) in the controls (P < 0.001). IAA was present in 14.5% (9 out of 62) of our GDM patients, and absent in the control subjects (P < 0.001). Anti-GAD65 was also present in GDM patients, with a prevalence of 3.2% (2 out of 62) while it was absent in the control group (P = NS). Pre-gestational weight was significantly lower (57.78 ± 9.8 vs 65.9 ± 17.3 <it>P </it>= 0.04) in auto-antibodies- positive GDM patients.</p> <p>Conclusion</p> <p>These results are in contrast with the very low prevalence of all antibodies reported in Italy. If confirmed, they could indicate that a large proportion of GDM patients in Sardinia have an autoimmune origin, in accordance with the high prevalence of Type 1 diabetes.</p> |
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issn | 1477-7827 |
language | English |
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spelling | doaj.art-e5e7fa1720f6454fb0ecfffa2ddaadbf2022-12-22T03:17:22ZengBMCReproductive Biology and Endocrinology1477-78272008-06-01612410.1186/1477-7827-6-24Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control reportMurenu MichelaSulis SimonettaMotzo CostantinoBerria RacheleZedda PierinaGarau NicolettaPortoghese ElaineOrrù MarisaMurgia CinziaPaoletti AnnaMelis Gian<p>Abstract</p> <p>Background</p> <p>We previously reported a high prevalence (22.3%) of gestational diabetes mellitus (GDM) in a large group of Sardinian women, in contrast with the prevalence of Type 2 diabetes. Sardinia has an unusual distribution of haplotypes and genotypes, with the highest population frequency of HLA DR3 in the world, and after Finland, the highest prevalence of Type 1 diabetes and Autoimmune-related Diseases. In this study we preliminarily tested the prevalence of serological markers of Type 1 diabetes in a group of Sardinian GDM patients.</p> <p>Methods</p> <p>We determined glutamic decarboxylase antibodies (anti-GAD65), protein tyrosine phosphatase ICA 512 (IA2) antibodies (anti-IA2), and IAA in 62 GDM patients, and in 56 controls with matching age, gestational age and parity.</p> <p>Results</p> <p>We found a high prevalence and very unusual distribution of antibodies in GDM patients (38.8%), the anti-IA2 being the most frequent antibody. Out of all our GDM patients, 38.8% (24 of 62) were positive for at least one antibody. Anti-IA2 was present in 29.0 % (18 out of 62) vs. 7.1% (4 out of 56) in the controls (P < 0.001). IAA was present in 14.5% (9 out of 62) of our GDM patients, and absent in the control subjects (P < 0.001). Anti-GAD65 was also present in GDM patients, with a prevalence of 3.2% (2 out of 62) while it was absent in the control group (P = NS). Pre-gestational weight was significantly lower (57.78 ± 9.8 vs 65.9 ± 17.3 <it>P </it>= 0.04) in auto-antibodies- positive GDM patients.</p> <p>Conclusion</p> <p>These results are in contrast with the very low prevalence of all antibodies reported in Italy. If confirmed, they could indicate that a large proportion of GDM patients in Sardinia have an autoimmune origin, in accordance with the high prevalence of Type 1 diabetes.</p>http://www.rbej.com/content/6/1/24 |
spellingShingle | Murenu Michela Sulis Simonetta Motzo Costantino Berria Rachele Zedda Pierina Garau Nicoletta Portoghese Elaine Orrù Marisa Murgia Cinzia Paoletti Anna Melis Gian Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report Reproductive Biology and Endocrinology |
title | Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report |
title_full | Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report |
title_fullStr | Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report |
title_full_unstemmed | Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report |
title_short | Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report |
title_sort | autoimmunity in gestational diabetes mellitus in sardinia a preliminary case control report |
url | http://www.rbej.com/content/6/1/24 |
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