Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPD
Abstract The study aims to assess the accuracy of the arterial blood gas (ABG) analysis in measuring hemoglobin, potassium, sodium, and glucose concentrations in comparison to standard venous blood analysis among patients diagnosed with chronic obstructive pulmonary disease (COPD). From January to M...
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| Format: | Article |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-55992-9 |
| _version_ | 1827327741643456512 |
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| author | Sitian Tang Zhu Mei Dongmei Huang Ling Liu Lunyu Yang Dan Yin Liyi Hu |
| author_facet | Sitian Tang Zhu Mei Dongmei Huang Ling Liu Lunyu Yang Dan Yin Liyi Hu |
| author_sort | Sitian Tang |
| collection | DOAJ |
| description | Abstract The study aims to assess the accuracy of the arterial blood gas (ABG) analysis in measuring hemoglobin, potassium, sodium, and glucose concentrations in comparison to standard venous blood analysis among patients diagnosed with chronic obstructive pulmonary disease (COPD). From January to March 2023, results of ABG analysis and simultaneous venous blood sampling among patients with COPD were retrospectively compared, without any intervention being applied between the two methods. The differences in hemoglobin, potassium, sodium, and glucose concentrations were assessed using a statistical software program (R software). There were significant differences in the mean concentrations of hemoglobin (p < 0.001), potassium (p < 0.001), and sodium (p = 0.001) between the results from ABG and standard venous blood analysis. However, the magnitude of the difference was within the total error allowance (TEa) of the United States of Clinical Laboratory Improvement Amendments (US-CLIA). As for the innovatively studied glucose concentrations, a statistically significant difference between the results obtained from ABG (7.8 ± 3.00) mmol·L−1 and venous blood (6.72 ± 2.44) mmol·L−1 was noted (p < 0.001), with the difference exceeding the TEa of US-CLIA. A linear relationship between venous blood glucose and ABG was obtained: venous blood glucose (mmol·L−1) = − 0.487 + 0.923 × ABG glucose (mmol·L−1), with R2 of 0.882. The hemoglobin, potassium, and sodium concentrations in ABG were reliable for guiding treatment in managing COPD emergencies. However, the ABG analysis of glucose was significantly higher as compared to venous blood glucose, and there was a positive correlation between the two methods. Thus, a linear regression equation in this study combined with ABG analysis could be helpful in quickly estimating venous blood glucose during COPD emergency treatment before the standard venous blood glucose was available from the medical laboratory. |
| first_indexed | 2024-03-07T15:06:41Z |
| format | Article |
| id | doaj.art-e5eb67ececf24b4d9435986e6ec150f3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:06:41Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e5eb67ececf24b4d9435986e6ec150f32024-03-05T18:54:16ZengNature PortfolioScientific Reports2045-23222024-03-011411710.1038/s41598-024-55992-9Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPDSitian Tang0Zhu Mei1Dongmei Huang2Ling Liu3Lunyu Yang4Dan Yin5Liyi Hu6People’s Hospital of Chongqing Liang Jiang New AreaPeople’s Hospital of Chongqing Liang Jiang New AreaPeople’s Hospital of Chongqing Liang Jiang New AreaPeople’s Hospital of Chongqing Liang Jiang New AreaPeople’s Hospital of Chongqing Liang Jiang New AreaPeople’s Hospital of Chongqing Liang Jiang New AreaPeople’s Hospital of Chongqing Liang Jiang New AreaAbstract The study aims to assess the accuracy of the arterial blood gas (ABG) analysis in measuring hemoglobin, potassium, sodium, and glucose concentrations in comparison to standard venous blood analysis among patients diagnosed with chronic obstructive pulmonary disease (COPD). From January to March 2023, results of ABG analysis and simultaneous venous blood sampling among patients with COPD were retrospectively compared, without any intervention being applied between the two methods. The differences in hemoglobin, potassium, sodium, and glucose concentrations were assessed using a statistical software program (R software). There were significant differences in the mean concentrations of hemoglobin (p < 0.001), potassium (p < 0.001), and sodium (p = 0.001) between the results from ABG and standard venous blood analysis. However, the magnitude of the difference was within the total error allowance (TEa) of the United States of Clinical Laboratory Improvement Amendments (US-CLIA). As for the innovatively studied glucose concentrations, a statistically significant difference between the results obtained from ABG (7.8 ± 3.00) mmol·L−1 and venous blood (6.72 ± 2.44) mmol·L−1 was noted (p < 0.001), with the difference exceeding the TEa of US-CLIA. A linear relationship between venous blood glucose and ABG was obtained: venous blood glucose (mmol·L−1) = − 0.487 + 0.923 × ABG glucose (mmol·L−1), with R2 of 0.882. The hemoglobin, potassium, and sodium concentrations in ABG were reliable for guiding treatment in managing COPD emergencies. However, the ABG analysis of glucose was significantly higher as compared to venous blood glucose, and there was a positive correlation between the two methods. Thus, a linear regression equation in this study combined with ABG analysis could be helpful in quickly estimating venous blood glucose during COPD emergency treatment before the standard venous blood glucose was available from the medical laboratory.https://doi.org/10.1038/s41598-024-55992-9 |
| spellingShingle | Sitian Tang Zhu Mei Dongmei Huang Ling Liu Lunyu Yang Dan Yin Liyi Hu Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPD Scientific Reports |
| title | Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPD |
| title_full | Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPD |
| title_fullStr | Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPD |
| title_full_unstemmed | Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPD |
| title_short | Comparative analysis of hemoglobin, potassium, sodium, and glucose in arterial blood gas and venous blood of patients with COPD |
| title_sort | comparative analysis of hemoglobin potassium sodium and glucose in arterial blood gas and venous blood of patients with copd |
| url | https://doi.org/10.1038/s41598-024-55992-9 |
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