Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis
Purpose: This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of <sup>18</sup>F-FDOPA PET in brain tumors. Methods: The study included 54 patients, 18 of whom received carbidopa, who underwent <sup>18</sup>F-FDOPA PET...
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/21/5340 |
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| author | Marie Bros Timothée Zaragori Fabien Rech Marie Blonski Gabriela Hossu Luc Taillandier Pierre-Yves Marie Antoine Verger |
| author_facet | Marie Bros Timothée Zaragori Fabien Rech Marie Blonski Gabriela Hossu Luc Taillandier Pierre-Yves Marie Antoine Verger |
| author_sort | Marie Bros |
| collection | DOAJ |
| description | Purpose: This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of <sup>18</sup>F-FDOPA PET in brain tumors. Methods: The study included 54 patients, 18 of whom received carbidopa, who underwent <sup>18</sup>F-FDOPA PET for newly diagnosed gliomas. SUV-derived, 105 radiomics features and TTP dynamic parameters were extracted from volumes of interest in healthy brains and tumors. Simulation of the effects of carbidopa on time-activity curves were generated. Results: All static and TTP dynamic parameters were significantly higher in healthy brain regions of premedicated patients (ΔSUV<sub>mean</sub> = +53%, ΔTTP = +48%, <i>p</i> < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correlated with SUV<sub>mean</sub> (absolute correlation coefficient ≥ 0.4). In tumors, premedication with carbidopa was an independent predictor of SUV<sub>mean</sub> (ΔSUV<sub>mean</sub> = +52%, <i>p</i> < 0.001) and TTP (ΔTTP = +24%, <i>p</i> = 0.025). All parameters were no longer significantly modified by carbidopa premedication when using ratios to healthy brain. Simulated data confirmed that carbidopa leads to higher tumor TTP values, corrected by the ratios. Conclusion: In <sup>18</sup>F-FDOPA PET, carbidopa induces similarly higher SUV and TTP dynamic parameters and similarly impacts SUV-dependent radiomics in healthy brain and tumor regions, which is compensated for by correcting for the tumor-to-healthy-brain ratio. This is a significant advantage for multicentric study harmonization. |
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| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:06:03Z |
| publishDate | 2021-10-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e5ef4850102e4b4e99bb04af7da0c8162023-11-22T20:33:49ZengMDPI AGCancers2072-66942021-10-011321534010.3390/cancers13215340Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric AnalysisMarie Bros0Timothée Zaragori1Fabien Rech2Marie Blonski3Gabriela Hossu4Luc Taillandier5Pierre-Yves Marie6Antoine Verger7Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000 Nancy, FranceDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000 Nancy, FranceDepartment of Neurosurgery, CHRU-Nancy, Université de Lorraine, F-54000 Nancy, FranceCentre de Recherche en Automatique de Nancy CRAN UMR 7039, CNRS, Université de Lorraine, F-54000 Nancy, FranceIADI UMR 1254, INSERM, Université de Lorraine, F-54000 Nancy, FranceCentre de Recherche en Automatique de Nancy CRAN UMR 7039, CNRS, Université de Lorraine, F-54000 Nancy, FranceDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000 Nancy, FranceDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000 Nancy, FrancePurpose: This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of <sup>18</sup>F-FDOPA PET in brain tumors. Methods: The study included 54 patients, 18 of whom received carbidopa, who underwent <sup>18</sup>F-FDOPA PET for newly diagnosed gliomas. SUV-derived, 105 radiomics features and TTP dynamic parameters were extracted from volumes of interest in healthy brains and tumors. Simulation of the effects of carbidopa on time-activity curves were generated. Results: All static and TTP dynamic parameters were significantly higher in healthy brain regions of premedicated patients (ΔSUV<sub>mean</sub> = +53%, ΔTTP = +48%, <i>p</i> < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correlated with SUV<sub>mean</sub> (absolute correlation coefficient ≥ 0.4). In tumors, premedication with carbidopa was an independent predictor of SUV<sub>mean</sub> (ΔSUV<sub>mean</sub> = +52%, <i>p</i> < 0.001) and TTP (ΔTTP = +24%, <i>p</i> = 0.025). All parameters were no longer significantly modified by carbidopa premedication when using ratios to healthy brain. Simulated data confirmed that carbidopa leads to higher tumor TTP values, corrected by the ratios. Conclusion: In <sup>18</sup>F-FDOPA PET, carbidopa induces similarly higher SUV and TTP dynamic parameters and similarly impacts SUV-dependent radiomics in healthy brain and tumor regions, which is compensated for by correcting for the tumor-to-healthy-brain ratio. This is a significant advantage for multicentric study harmonization.https://www.mdpi.com/2072-6694/13/21/5340DOPAPETcarbidopagliomadynamicradiomics |
| spellingShingle | Marie Bros Timothée Zaragori Fabien Rech Marie Blonski Gabriela Hossu Luc Taillandier Pierre-Yves Marie Antoine Verger Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis Cancers DOPA PET carbidopa glioma dynamic radiomics |
| title | Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis |
| title_full | Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis |
| title_fullStr | Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis |
| title_full_unstemmed | Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis |
| title_short | Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis |
| title_sort | effects of carbidopa premedication on sup 18 sup f fdopa pet imaging of glioma a multiparametric analysis |
| topic | DOPA PET carbidopa glioma dynamic radiomics |
| url | https://www.mdpi.com/2072-6694/13/21/5340 |
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