Signaling via the Interleukin-10 Receptor Attenuates Cardiac Hypertrophy in Mice During Pressure Overload, but not Isoproterenol Infusion

Signaling via the Interleukin-10 Receptor Attenuates Cardiac Hypertrophy in Mice During Pressure Overload, but not Isoproterenol Infusion

Inflammation plays a key role during cardiac hypertrophy and the development of heart failure. Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that is expressed in the heart and may play a crucial role in cardiac remodeling. Based on the evidence that IL-10 potentially reduces pathologi...

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Bibliographic Details
Main Authors: Nicholas Stafford, Farryah Assrafally, Sukhpal Prehar, Min Zi, Ana M. De Morais, Arfa Maqsood, Elizabeth J. Cartwright, Werner Mueller, Delvac Oceandy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
interleukin-10
cardiac hypertrophy
signaling pathway
inflammation
heart failure
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.559220/full

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