Cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti-inflammatory drugs
Subjects and methods. The follow-up included 66 patients (34 women and 32 men) who took NSAIDs for emergent low back pain. Results. The findings may suggest that etoricoxib-based therapy is highly effective and relatively safe for the management of acute nonspecific backache in patients with comorbi...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2015-05-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31742 |
| _version_ | 1818961932245270528 |
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| author | I E Poverennova I A Zolotovskaya |
| author_facet | I E Poverennova I A Zolotovskaya |
| author_sort | I E Poverennova |
| collection | DOAJ |
| description | Subjects and methods. The follow-up included 66 patients (34 women and 32 men) who took NSAIDs for emergent low back pain. Results. The findings may suggest that etoricoxib-based therapy is highly effective and relatively safe for the management of acute nonspecific backache in patients with comorbidity. The important feature is the established tendency towards BP destabilization in patients with chronic cerebrovascular diseases treated with NSAIDs (diclofenac, meloxicam, to a lesser extent, nimesulide). After completion of drug intake for 14 days or longer, acute cerebral circulatory disorder and acute cerebrovascular event developed within 4.5 months in 3 and 2 patients, respectively. Conclusion. Thus, the spectrum of possible adverse cardiovascular effects of NSAIDs is rather broad. It is advisable to identify two major groups of NSAID-associated complications: 1) destabilized hypertension; 2) cardiovascular and cerebrovascular events. |
| first_indexed | 2024-12-20T12:21:17Z |
| format | Article |
| id | doaj.art-e5f2ac1548d347cfb01751d86fa4adfd |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-20T12:21:17Z |
| publishDate | 2015-05-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-e5f2ac1548d347cfb01751d86fa4adfd2022-12-21T19:40:59Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422015-05-01875535728758Cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti-inflammatory drugsI E PoverennovaI A ZolotovskayaSubjects and methods. The follow-up included 66 patients (34 women and 32 men) who took NSAIDs for emergent low back pain. Results. The findings may suggest that etoricoxib-based therapy is highly effective and relatively safe for the management of acute nonspecific backache in patients with comorbidity. The important feature is the established tendency towards BP destabilization in patients with chronic cerebrovascular diseases treated with NSAIDs (diclofenac, meloxicam, to a lesser extent, nimesulide). After completion of drug intake for 14 days or longer, acute cerebral circulatory disorder and acute cerebrovascular event developed within 4.5 months in 3 and 2 patients, respectively. Conclusion. Thus, the spectrum of possible adverse cardiovascular effects of NSAIDs is rather broad. It is advisable to identify two major groups of NSAID-associated complications: 1) destabilized hypertension; 2) cardiovascular and cerebrovascular events.https://ter-arkhiv.ru/0040-3660/article/view/31742cerebrovascular risksbackachenonsteroidal anti-inflammatory drugs |
| spellingShingle | I E Poverennova I A Zolotovskaya Cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti-inflammatory drugs Терапевтический архив cerebrovascular risks backache nonsteroidal anti-inflammatory drugs |
| title | Cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti-inflammatory drugs |
| title_full | Cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti-inflammatory drugs |
| title_fullStr | Cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti-inflammatory drugs |
| title_full_unstemmed | Cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti-inflammatory drugs |
| title_short | Cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti-inflammatory drugs |
| title_sort | cerebrovascular risks and prediction of complications in patients with backache during therapy with nonsteroidal anti inflammatory drugs |
| topic | cerebrovascular risks backache nonsteroidal anti-inflammatory drugs |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31742 |
| work_keys_str_mv | AT iepoverennova cerebrovascularrisksandpredictionofcomplicationsinpatientswithbackacheduringtherapywithnonsteroidalantiinflammatorydrugs AT iazolotovskaya cerebrovascularrisksandpredictionofcomplicationsinpatientswithbackacheduringtherapywithnonsteroidalantiinflammatorydrugs |