Assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patients
Cardiotoxicity is a side effect of anthracycline-based chemotherapy. Clinical and prognostic significance of left ventricular diastolic dysfunction in heart failure patients is undeniable.The aim. To assess dynamic changes in the left ventricular diastolic function after anthracycline-based chemothe...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2022-07-01
|
| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/3559 |
| _version_ | 1797237235320356864 |
|---|---|
| author | A. N. Sumin A. V. Shcheglova Yu. S. Slepynina A. V. Ivanova O. M. Polikutina |
| author_facet | A. N. Sumin A. V. Shcheglova Yu. S. Slepynina A. V. Ivanova O. M. Polikutina |
| author_sort | A. N. Sumin |
| collection | DOAJ |
| description | Cardiotoxicity is a side effect of anthracycline-based chemotherapy. Clinical and prognostic significance of left ventricular diastolic dysfunction in heart failure patients is undeniable.The aim. To assess dynamic changes in the left ventricular diastolic function after anthracycline-based chemotherapy (ANT) in breast cancer patients.Material and methods. The study included 40 women aged 35 to 72 years with breast cancer (BC) undergoing ANT chemotherapy. The main group (n = 40) consisted of women with breast cancer examined at admission, after 6 months the same women (n = 37) were examined again. Women without breast cancer (n = 25) were used as the control group.Results. Dynamic changes in mitral annular velocities were revealed by Doppler tissue imaging. Lateral early diastolic mitral annular velocity (e’ lateral) was significantly lower in breast cancer patients as compared to the control group (p = 0.031). Six months after ANT chemotherapy, there was a definite increase in the lateral late diastolic mitral annular velocity (a’ lateral) (p = 0.033). Average early diastolic transmitral flow velocity to early diastolic velocity (E/e’ lateral) ratio was within the normative values in all groups, but E/e’ lateral in the main group was higher compared to the control group (p = 0.003). In the main group, septal early diastolic mitral annular velocity (e’ septal) was lower compared to the control group (p = 0.0005). Moreover, an increase in the septal mitral annular velocity (a’ septal) (p = 0.01) and higher E/e’ septal ratio (p = 0.011) were revealed during dynamic observation. Multiple logistic regression disclosed that E/A, e’ lateral, e’/a’ lateral, and E/e’ lateral were affected by heart rate, psychological status, age, hypertension, and body mass index, but not anthracycline chemotherapy. The total dose of anthracycline was independently associated with e’ septal and E/e’ septal: F(4.18) = 16.466 (p < 0.001; R2 = 0.775) and F(3.16) = 7.271 (p = 0.004; R2 = 0.627).Conclusion. Left ventricular diastolic function worsens in women undergoing anthracycline-based chemotherapy for breast cancer (lower e’, e’/a’ lateral, and e’ septal, higher E/e’ septal ratio). However, anthracycline does not significantly affect LVEF and LV deformation indicators. E/e’ septalande’ septal are independently associated with the total dose of anthracycline. |
| first_indexed | 2024-03-08T12:15:27Z |
| format | Article |
| id | doaj.art-e5f2cb8c51854ed79e59f7b795256e3a |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:16:31Z |
| publishDate | 2022-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-e5f2cb8c51854ed79e59f7b795256e3a2024-03-28T07:49:26ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962022-07-017312113310.29413/ABS.2022-7.3.132349Assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patientsA. N. Sumin0A. V. Shcheglova1Yu. S. Slepynina2A. V. Ivanova3O. M. Polikutina4Kuzbass Cardiology CenterKuzbass Cardiology CenterKuzbass Cardiology CenterKuzbass Cardiology CenterKuzbass Cardiology CenterCardiotoxicity is a side effect of anthracycline-based chemotherapy. Clinical and prognostic significance of left ventricular diastolic dysfunction in heart failure patients is undeniable.The aim. To assess dynamic changes in the left ventricular diastolic function after anthracycline-based chemotherapy (ANT) in breast cancer patients.Material and methods. The study included 40 women aged 35 to 72 years with breast cancer (BC) undergoing ANT chemotherapy. The main group (n = 40) consisted of women with breast cancer examined at admission, after 6 months the same women (n = 37) were examined again. Women without breast cancer (n = 25) were used as the control group.Results. Dynamic changes in mitral annular velocities were revealed by Doppler tissue imaging. Lateral early diastolic mitral annular velocity (e’ lateral) was significantly lower in breast cancer patients as compared to the control group (p = 0.031). Six months after ANT chemotherapy, there was a definite increase in the lateral late diastolic mitral annular velocity (a’ lateral) (p = 0.033). Average early diastolic transmitral flow velocity to early diastolic velocity (E/e’ lateral) ratio was within the normative values in all groups, but E/e’ lateral in the main group was higher compared to the control group (p = 0.003). In the main group, septal early diastolic mitral annular velocity (e’ septal) was lower compared to the control group (p = 0.0005). Moreover, an increase in the septal mitral annular velocity (a’ septal) (p = 0.01) and higher E/e’ septal ratio (p = 0.011) were revealed during dynamic observation. Multiple logistic regression disclosed that E/A, e’ lateral, e’/a’ lateral, and E/e’ lateral were affected by heart rate, psychological status, age, hypertension, and body mass index, but not anthracycline chemotherapy. The total dose of anthracycline was independently associated with e’ septal and E/e’ septal: F(4.18) = 16.466 (p < 0.001; R2 = 0.775) and F(3.16) = 7.271 (p = 0.004; R2 = 0.627).Conclusion. Left ventricular diastolic function worsens in women undergoing anthracycline-based chemotherapy for breast cancer (lower e’, e’/a’ lateral, and e’ septal, higher E/e’ septal ratio). However, anthracycline does not significantly affect LVEF and LV deformation indicators. E/e’ septalande’ septal are independently associated with the total dose of anthracycline.https://www.actabiomedica.ru/jour/article/view/3559left ventricular dysfunctionanticancer therapybreast canceranthracyclines |
| spellingShingle | A. N. Sumin A. V. Shcheglova Yu. S. Slepynina A. V. Ivanova O. M. Polikutina Assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patients Acta Biomedica Scientifica left ventricular dysfunction anticancer therapy breast cancer anthracyclines |
| title | Assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patients |
| title_full | Assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patients |
| title_fullStr | Assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patients |
| title_full_unstemmed | Assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patients |
| title_short | Assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patients |
| title_sort | assessment of left ventricular diastolic dysfunction following anthracyclinebased chemotherapy in breast cancer patients |
| topic | left ventricular dysfunction anticancer therapy breast cancer anthracyclines |
| url | https://www.actabiomedica.ru/jour/article/view/3559 |
| work_keys_str_mv | AT ansumin assessmentofleftventriculardiastolicdysfunctionfollowinganthracyclinebasedchemotherapyinbreastcancerpatients AT avshcheglova assessmentofleftventriculardiastolicdysfunctionfollowinganthracyclinebasedchemotherapyinbreastcancerpatients AT yusslepynina assessmentofleftventriculardiastolicdysfunctionfollowinganthracyclinebasedchemotherapyinbreastcancerpatients AT avivanova assessmentofleftventriculardiastolicdysfunctionfollowinganthracyclinebasedchemotherapyinbreastcancerpatients AT ompolikutina assessmentofleftventriculardiastolicdysfunctionfollowinganthracyclinebasedchemotherapyinbreastcancerpatients |