Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV-2 variants and coronavirus lineages is essential. We describe a highly conserved, conformational S2 domain epitope present only in the...

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Bibliographic Details
Main Authors: Rui P Silva, Yimin Huang, Annalee W Nguyen, Ching-Lin Hsieh, Oladimeji S Olaluwoye, Tamer S Kaoud, Rebecca E Wilen, Ahlam N Qerqez, Jun-Gyu Park, Ahmed M Khalil, Laura R Azouz, Kevin C Le, Amanda L Bohanon, Andrea M DiVenere, Yutong Liu, Alison G Lee, Dzifa A Amengor, Sophie R Shoemaker, Shawn M Costello, Eduardo A Padlan, Susan Marqusee, Luis Martinez-Sobrido, Kevin N Dalby, Sheena D'Arcy, Jason S McLellan, Jennifer A Maynard
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
coronavirus
MERS-CoV
spike
SARS-CoV-2
S2 core
S2 hinge
Online Access:https://elifesciences.org/articles/83710

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