Migraine and cluster headache – the common link
Abstract Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also sug...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s10194-018-0909-4 |
| _version_ | 1819241551249801216 |
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| author | Anne Luise Vollesen Silvia Benemei Francesca Cortese Alejandro Labastida-Ramírez Francesca Marchese Lanfranco Pellesi Michele Romoli Messoud Ashina Christian Lampl on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS) |
| author_facet | Anne Luise Vollesen Silvia Benemei Francesca Cortese Alejandro Labastida-Ramírez Francesca Marchese Lanfranco Pellesi Michele Romoli Messoud Ashina Christian Lampl on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS) |
| author_sort | Anne Luise Vollesen |
| collection | DOAJ |
| description | Abstract Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients. |
| first_indexed | 2024-12-23T14:25:42Z |
| format | Article |
| id | doaj.art-e5f5c9034def454a81fe0d5f0915a6ea |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-12-23T14:25:42Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-e5f5c9034def454a81fe0d5f0915a6ea2022-12-21T17:43:41ZengBMCThe Journal of Headache and Pain1129-23691129-23772018-09-0119111510.1186/s10194-018-0909-4Migraine and cluster headache – the common linkAnne Luise Vollesen0Silvia Benemei1Francesca Cortese2Alejandro Labastida-Ramírez3Francesca Marchese4Lanfranco Pellesi5Michele Romoli6Messoud Ashina7Christian Lampl8on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of CopenhagenHealth Sciences Department, University of Florence and Headache Centre, Careggi University HospitalDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza, University of RomeDep Internal Medicine, Division of Vascular Pharmacology, Erasmus Medical CenterChild Neuropsichiatry Unit, University of PalermoMedical Toxicology, Headache and Drug Abuse Center, University of Modena and Reggio EmiliaNeurology Clinic, University of Perugia - S.M. Misericordiae HospitalDanish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neurogeriatric Medicine, Headache Medical Center Linz, Ordensklinikum Linz Barmherzige SchwesternAbstract Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.http://link.springer.com/article/10.1186/s10194-018-0909-4MigraineCluster headacheCalcitonin gene-related peptide (CGRP)Anti-CGRP (receptor) monoclonal antibodies – mAbsNeuromodulationTrigeminovascular system |
| spellingShingle | Anne Luise Vollesen Silvia Benemei Francesca Cortese Alejandro Labastida-Ramírez Francesca Marchese Lanfranco Pellesi Michele Romoli Messoud Ashina Christian Lampl on behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS) Migraine and cluster headache – the common link The Journal of Headache and Pain Migraine Cluster headache Calcitonin gene-related peptide (CGRP) Anti-CGRP (receptor) monoclonal antibodies – mAbs Neuromodulation Trigeminovascular system |
| title | Migraine and cluster headache – the common link |
| title_full | Migraine and cluster headache – the common link |
| title_fullStr | Migraine and cluster headache – the common link |
| title_full_unstemmed | Migraine and cluster headache – the common link |
| title_short | Migraine and cluster headache – the common link |
| title_sort | migraine and cluster headache the common link |
| topic | Migraine Cluster headache Calcitonin gene-related peptide (CGRP) Anti-CGRP (receptor) monoclonal antibodies – mAbs Neuromodulation Trigeminovascular system |
| url | http://link.springer.com/article/10.1186/s10194-018-0909-4 |
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