Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130

Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130

Abstract Background Retinal detachment (RD) can lead to proliferative vitreoretinopathy (PVR), a leading cause of intractable vision loss. PVR is associated with a cytokine storm involving common proinflammatory molecules like IL6, but little is known about the source and downstream signaling of IL6...

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Bibliographic Details
Main Authors: Xinlei Wang, Eric B. Miller, Mayank Goswami, Pengfei Zhang, Kaitryn E. Ronning, Sarah J. Karlen, Robert J. Zawadzki, Edward N. Pugh, Marie E. Burns
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Neuroinflammation
Subjects:
Retinal detachment
Monocyte
Interleukin 6
IL6 Rα
gp130
CCL2
Online Access:http://link.springer.com/article/10.1186/s12974-017-0886-6

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