Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma
<p>Abstract</p> <p>Background</p> <p>The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for tre...
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| Format: | Article |
| Language: | English |
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BMC
2012-09-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
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| Online Access: | http://www.jeccr.com/content/31/1/78 |
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| author | Bobyk Laure Edouard Magali Deman Pierre Rousseau Julia Adam Jean-François Ravanat Jean-Luc Estève François Balosso Jacques Barth Rolf F Elleaume Hélène |
| author_facet | Bobyk Laure Edouard Magali Deman Pierre Rousseau Julia Adam Jean-François Ravanat Jean-Luc Estève François Balosso Jacques Barth Rolf F Elleaume Hélène |
| author_sort | Bobyk Laure |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats.</p> <p>Methods</p> <p>Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using Alzet<sup>TM</sup> osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays.</p> <p>Results</p> <p>Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons.</p> <p>Conclusions</p> <p>These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays.</p> |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-16T23:52:55Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-e5f7cdceb706410f88df6462d75cafad2022-12-21T22:11:17ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662012-09-013117810.1186/1756-9966-31-78Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat gliomaBobyk LaureEdouard MagaliDeman PierreRousseau JuliaAdam Jean-FrançoisRavanat Jean-LucEstève FrançoisBalosso JacquesBarth Rolf FElleaume Hélène<p>Abstract</p> <p>Background</p> <p>The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats.</p> <p>Methods</p> <p>Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using Alzet<sup>TM</sup> osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays.</p> <p>Results</p> <p>Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons.</p> <p>Conclusions</p> <p>These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays.</p>http://www.jeccr.com/content/31/1/78F98 rat gliomaCarboplatinOsmotic pumpsIntracerebral deliveryRadiotherapy with 6 MV photons or synchrotron X-rays |
| spellingShingle | Bobyk Laure Edouard Magali Deman Pierre Rousseau Julia Adam Jean-François Ravanat Jean-Luc Estève François Balosso Jacques Barth Rolf F Elleaume Hélène Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma Journal of Experimental & Clinical Cancer Research F98 rat glioma Carboplatin Osmotic pumps Intracerebral delivery Radiotherapy with 6 MV photons or synchrotron X-rays |
| title | Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma |
| title_full | Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma |
| title_fullStr | Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma |
| title_full_unstemmed | Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma |
| title_short | Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma |
| title_sort | intracerebral delivery of carboplatin in combination with either 6 mv photons or monoenergetic synchrotron x rays are equally efficacious for treatment of the f98 rat glioma |
| topic | F98 rat glioma Carboplatin Osmotic pumps Intracerebral delivery Radiotherapy with 6 MV photons or synchrotron X-rays |
| url | http://www.jeccr.com/content/31/1/78 |
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