The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With Schizophrenia
Background: Schizophrenia is a severe mental disease which characterized by positive symptom, negative symptom, general pathology syndrome and cognitive deficits. In recent years, many studies have investigated the relationship between cognitive deficits and clinical characteristics in schizophrenia...
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.638773/full |
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| author | Xing-Jie Peng Gang-Rui Hei Ye Yang Chen-Chen Liu Jing-Mei Xiao Yu-Jun Long Jing Huang Jing-Ping Zhao Ren-Rong Wu Ren-Rong Wu |
| author_facet | Xing-Jie Peng Gang-Rui Hei Ye Yang Chen-Chen Liu Jing-Mei Xiao Yu-Jun Long Jing Huang Jing-Ping Zhao Ren-Rong Wu Ren-Rong Wu |
| author_sort | Xing-Jie Peng |
| collection | DOAJ |
| description | Background: Schizophrenia is a severe mental disease which characterized by positive symptom, negative symptom, general pathology syndrome and cognitive deficits. In recent years, many studies have investigated the relationship between cognitive deficits and clinical characteristics in schizophrenia, but relatively few studies have been performed on first-episode drug-naïve patients.Methods: Eighty seven first-episode drug-naïve schizophrenia patients were assessed for positive symptom, negative symptom, general pathology symptom and cognitive deficits from the Positive and Negative Symptom Scale and MATRICS Consensus Cognitive Battery. Psychotics depression were assessed using the Calgary depressing scale for schizophrenia. The relationship between clinical characteristics and cognitive deficits were assessed using correlation analysis and linear regression analysis.Results: The prevalence of cognitive deficits among the patients in our study was 85.1% (74/87) which was much higher than that in the general population. According to correlation analysis, negative symptom was negatively correlated with speed of processing and social cognition, and general pathology showed a negative correlation with attention/vigilance. In addition, a positive correlation was found between age and speed of processing. No correlation was found between cognitive deficits and positive symptom.Conclusions: This study confirmed that negative symptom is negatively related with some domains of cognitive function in first-episode drug naïve schizophrenia patients.Trail Registration: NCT02880462. Registered August 26, 2016. |
| first_indexed | 2024-04-12T00:57:22Z |
| format | Article |
| id | doaj.art-e5f81d87a5f24a9e9b6547aa1294def0 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T00:57:22Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-e5f81d87a5f24a9e9b6547aa1294def02022-12-22T03:54:35ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-02-011210.3389/fpsyt.2021.638773638773The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With SchizophreniaXing-Jie Peng0Gang-Rui Hei1Ye Yang2Chen-Chen Liu3Jing-Mei Xiao4Yu-Jun Long5Jing Huang6Jing-Ping Zhao7Ren-Rong Wu8Ren-Rong Wu9National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University; National Technology Institute on Mental Disorders; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, ChinaShanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, ChinaBackground: Schizophrenia is a severe mental disease which characterized by positive symptom, negative symptom, general pathology syndrome and cognitive deficits. In recent years, many studies have investigated the relationship between cognitive deficits and clinical characteristics in schizophrenia, but relatively few studies have been performed on first-episode drug-naïve patients.Methods: Eighty seven first-episode drug-naïve schizophrenia patients were assessed for positive symptom, negative symptom, general pathology symptom and cognitive deficits from the Positive and Negative Symptom Scale and MATRICS Consensus Cognitive Battery. Psychotics depression were assessed using the Calgary depressing scale for schizophrenia. The relationship between clinical characteristics and cognitive deficits were assessed using correlation analysis and linear regression analysis.Results: The prevalence of cognitive deficits among the patients in our study was 85.1% (74/87) which was much higher than that in the general population. According to correlation analysis, negative symptom was negatively correlated with speed of processing and social cognition, and general pathology showed a negative correlation with attention/vigilance. In addition, a positive correlation was found between age and speed of processing. No correlation was found between cognitive deficits and positive symptom.Conclusions: This study confirmed that negative symptom is negatively related with some domains of cognitive function in first-episode drug naïve schizophrenia patients.Trail Registration: NCT02880462. Registered August 26, 2016.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.638773/fullcognitive impairmentfirst episode drug-naïve schizophreniaMCCBcorrelation analysispositive and negative symptoms |
| spellingShingle | Xing-Jie Peng Gang-Rui Hei Ye Yang Chen-Chen Liu Jing-Mei Xiao Yu-Jun Long Jing Huang Jing-Ping Zhao Ren-Rong Wu Ren-Rong Wu The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With Schizophrenia Frontiers in Psychiatry cognitive impairment first episode drug-naïve schizophrenia MCCB correlation analysis positive and negative symptoms |
| title | The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With Schizophrenia |
| title_full | The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With Schizophrenia |
| title_fullStr | The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With Schizophrenia |
| title_full_unstemmed | The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With Schizophrenia |
| title_short | The Association Between Cognitive Deficits and Clinical Characteristic in First-Episode Drug Naïve Patients With Schizophrenia |
| title_sort | association between cognitive deficits and clinical characteristic in first episode drug naive patients with schizophrenia |
| topic | cognitive impairment first episode drug-naïve schizophrenia MCCB correlation analysis positive and negative symptoms |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.638773/full |
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